Background: Atopic dermatitis (AD) is chronic relapsing, pruritic, inflammatory skin disease. It usually accompanies other atopic problems like asthma and allergic rhinitis. Eosinophil plays a role in patients with AD. Objectives: To assess blood eosinophils in patients with AD and to evaluate the factors that are affecting the blood eosinophilia. Materials and methods: This prospective study was conducted at Hit General Hospital in the period from October 2018-October 2019. The age, gender, and personal or family history of asthma or allergic rhinitis of the patients with AD were recorded. The severity of the disease was assessed by the SCORAD score. The total number of eosinophil was measured for each subject. The data were analyzed using SPSS version 22. Results: Out of 70 patients with AD, 38 (54.3%) were females, and 32 (45.7%) males. The age of the patients ranged from 8 months to 30 years (mean 7.59±7.40). The highest age group affected was 2-12 years 40 (57.1%). The SCORAD score ranged from 6-80 (mean 24.19±17.59). The majority of our patients with mild course 50 (71.1%). The majority of the cases were without a history of asthma (n=53,75.7%), and around 50% without allergic rhinitis. The range of eosinophil count was 42-3360 (mean 636.44±491.37). The majority of the subjects (n=53,75.7%) with mild eosinophilia (500-1500/ mm 3 ). The age, gender, and patients with a history of allergic rhinitis or asthma had no significant effect on the number of eosinophils (P-Value >0.05). While, there was a high statistically significant difference between the eosinophils count, and the severity of AD (P-Value=0.000). Conclusion: From these findings we concluded that blood eosinophilia is a relatively common laboratory finding of AD. Blood eosinophilia was influenced by the severity of AD.
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