Diagnostic evaluation of women experiencing repeated in vitro fertilization failure

Vaquero, E.; Lazzarin, Natalia; Caserta, Donatella; Valensise, H.; Baldi, Marina; Mangino, Massimo; Arduini, Domenico

doi:10.1016/j.ejogrb.2005.08.001

Cited by 67 publications

(74 citation statements)

References 28 publications

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“…Vaquero et al published similar results 16 . They also failed to find an increased occurrence of thrombophilia in patients with at least one IVF cycle failure (n = 51).…”

Section: Discussionsupporting

confidence: 76%

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Machac¹,

Ľubušký²,

Procházka³

et al. 2006

BIOMED PAP

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Background and objective:To determine the prevalence of markers of inherited thrombophilia in patients with severe form of ovarian hyperstimulation syndrome (OHSS) Design and methods: Blood samples were analysed for markers of thrombophilia (mutation of factor V -Leiden, mutation of methylentetrahydrofolat reductase (MTHFR) C677T and mutation of prothrombin G20210A). The study group consisted of women who had undergone controlled ovarian hyperstimulation for IVF complicated by severe OHSS (group A, n = 50). Results were compared with two controls groups -women who underwent ovarian hyperstimulation for IVF without developing OHSS (group B, n = 93) and healthy pregnant women with no history of infertility (group C, n = 196).Results: We have found 7 out of 50 patients from group A positive for Leiden mutation (heterozygous) 11 out of 93 from group B (heterozygous), p = 0.71 OR 1.21 (0.39 3.70) and 10 out of 196 from group C (heterozygous), p = 0.03 OR 3.03 (0.97 9.28). Polymorphism of MTHFR 677T gene was detected in 17 out of 50 patients (heterozygous) from group A, in 36 out of 93 patients from group B (35 heterozygous, 1 homozygous) and in 93 out of 196 patients from the group C (86 heterozygous, 7 homozygous) with no statistical significance. Conclusions:We found an increased prevalence of factor V Leiden mutation in Czech infertile women. However carriers of Leiden mutation had no enhanced risk of development severe form of OHSS during stimulation.

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“…Vaquero et al published similar results 16 . They also failed to find an increased occurrence of thrombophilia in patients with at least one IVF cycle failure (n = 51).…”

Section: Discussionsupporting

confidence: 76%

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Machac¹,

Ľubušký²,

Procházka³

et al. 2006

BIOMED PAP

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“…A large number of articles suggest a higher prevalence of inherited thrombophilias in recurrent implantation failure compared with healthy parous women [7,21,22]. However, other studies have opposite outcomes.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, a similar study surveyed the role of the coagulation/fibrinolytic system in implantation and found that patients with recurrent implantation failure experienced reduced plasma fibrinolytic potential compared with fertile controls or patients with the first cycle of IVF [6]. Conversely, other investigators have also studied the correlations between thrombophilias and implantation, and have conflicting results [7,8]. These studies examined the effects of inherited thrombophilias not on factor V Leiden, prothrombin, Capsule IVF outcomes are not associated with FVL, PGM, MTHFR (C677T), MTHFR (A1298C), and APCR mutation in inherited thrombophilias.…”

Section: Introductionmentioning

confidence: 98%

Association between in vitro fertilization outcomes and inherited thrombophilias: a meta-analysis

Tan

Sao

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study was to determine whether in vitro fertilization (IVF) outcomes are associated with inherited thrombophilias. Methods Several databases including PubMed, Embase, and Cochrane Library were retrieved up to 12 January 2016. The quality of the included studies was assessed by two authors. The associations of the following mutations in inherited thrombophilias and IVF outcomes were explored: factor V Leiden (FVL), prothrombin gene G20210A mutation (PGM), 5,10-methylentetrahydrofolate reductase (MTHFR) C677T, MTHFR (A1298C) and activated protein C resistance (APCR). The main outcome measures included CPR and implantation rate (IR). The relative risk (RR) and its 95 % confidence interval (CI) were calculated for effect index. Heterogeneity test was evaluated by Chi-square based on Q statistic and I 2 statistics. Results A total of seven articles published between 2007 and 2015 with the ages of subjects between 30.9 and 36.2 were included. For subgroups analysis of CPR or IR, there were no significant differences in MTHFR (C377T), MTHFR (A1298C), FVL, PGM, and FVL/PGM mutation were found between the mutation group and control group (P > 0. 05). Conclusions IVF outcomes are not associated with FVL, PGM, MTHFR (C677T), MTHFR (A1298C), and APCR mutation in inherited thrombophilias.

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“…Current literature has conflicting findings in relation to the role of thrombophilia and its impact on repeat IVF failure. While some studies have suggested that repeat IVF failure may be associated with an increased incidence of thrombophilia [37][38][39][40][41] others have negated such an association [42][43][44]. In a recent systemic review and metaanalysis, pooled data from patients in 8 case control studies showed an overall 3-fold increased risk of ART failure in association with factor V Leiden; while in the 3 cohort studies there was no difference in outcome between those with and those without factor V Leiden mutation [45].…”

Section: Discussionmentioning

confidence: 99%

Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

Younis

Ben‐Ami

Izhaki

et al. 2013

J Assist Reprod Genet

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Purpose In the last few years more robust evidence is emerging to point out at an increased rate of prematurity and low birth weight in singleton pregnancies following ART. Whether this increased rate is related to ART practice or to infertility per se, is still an open question. Our aim in this study was to explore this question by evaluating Protein C (ProC) Global assay in infertile women before ART treatment. Methods A cohort of 95 unselected and consecutive infertile women, eligible for ART, was prospectively recruited for the study. The control group included 77 matched healthy fertile women with a history of spontaneous conceptions. Pro C Global assay was evaluated in both groups. A full thrombophilic work-up was performed in the study group.Results ProC Global assay level was found to be significantly lower in the study as compared to the control group, corresponding to 0.78 ± 0.16 and 0.88 ± 0.16, respectively (P <0.01). As well, abnormal ProC Global assay level of ≤0.8 was significantly higher in the study as compared to control group corresponding to 53 % and 29 %, respectively. ProC Global assay level was significantly lower in women within the study group found to have APCR, factor V Leiden and high factor VIII level, any thrombophilia or combined thrombophilia when compared to women without these thrombophilic risk factors. Conclusions Reduced ProC Global assay level is encountered in infertile women prior to ART treatment. This finding may suggest a unique anticoagulation Protein C pathway in infertile as compared to fertile women. Further studies are encouraged to explore this finding.

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Diagnostic evaluation of women experiencing repeated in vitro fertilization failure

Cited by 67 publications

References 28 publications

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Association between in vitro fertilization outcomes and inherited thrombophilias: a meta-analysis

Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

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