Diagnostic criteria in proliferative verrucous leukoplakia: Evaluation

Abstract

Objectives: to evaluate the ability of the diagnostic criteria proposed by Cerero et al in 2010 to perform an early diagnose in patients with proliferative verrucous leukoplakia. Study Design: retrospective study with patients diagnosed with leukoplakia at Oral Medicine Service at Oral Medicine and Surgery Department at Dentistry Faculty at Universidad Complutense of Madrid. Results: the criteria were applied in 116 patients, turning positive in 40 cases. Out of these, 24 (60%) had been previously diagnosed with PVL. Most frequent criteria were major criteria A and E, concerning lesion’s site and histopathology, and minor criteria b and c, concerning sex and smoking habit. Conclusions: diagnostic criteria developed by Cerero et al can be a useful tool for an early diagnose of PVL, as in 60% of the cases, the criteria would have allowed to make an early diagnose of the disease. Key words:Proliferative verrucous leukoplakia, criteria, diagnose, early.

Proliferative leukoplakia: Proposed new clinical diagnostic criteria

“…More than half of the cases of PVL in this series (56.4%) exhibited no evidence of epithelial dysplasia at first biopsy, but hyperkeratosis or parakeratosis with epithelial atrophy or acanthosis. This is similar to the data reported by Garcia‐Chias, Casado‐De La Cruz, Esparza‐Gomez, and Cerero‐Lapiedra () where 50% of cases exhibited hyperkeratosis without dysplasia (KUS) and 50% showed dysplasia. In their systematic review Pentenero et al.…”

Inter-observer Variability in the Diagnosis of Proliferative Verrucous Leukoplakia: Clinical Implications for Oral and Maxillofacial Surgeon Understanding: A Collaborative Pilot Study

“…Studies published in the past followed the diagnostic criteria developed by Hansen et al [1]. Later, reformulated criteria for early diagnosis and better management of PVL was recommended by many authors [16][17][18][19][20]. Understanding the biologic potential of VH, atypical verrucous lesions, and atypical epithelial lesions is perplexing in the current literature [19,21].…”

Proliferative verrucous leukoplakia: a case report with characteristics of long‐term progression

“…The following oral subsites are recognised: dorsum of the tongue (unilateral or bilateral), border of the tongue, cheek mucosa, alveolar mucosa or gingiva upper jaw, alveolar mucosa or gingiva lower jaw, hard and soft palate, floor of the mouth, upper lip and lower lip; (2) when adding all involved sites, the minimum seize should be at least 3 cm; (3) a well‐documented period of disease evolution of at least 5 years, being characterised by spreading and enlarging and the occurrence of one or more recurrences in a previously treated area; and (4) the availability of at least one biopsy in order to rule out the presence of a verrucous carcinoma or squamous cell carcinoma. On the other hand, García‐Chías et al . reviewed the criteria of Cerero‐Lapiedra et al .…”