Diagnostic Criteria and Prevalence of Sarcopenia in the Elderly

Safonova, J A; Glazunova, G. M.

doi:10.1134/s2079057020030145

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…These include non-invasive, portable modalities such as quantitative musculoskeletal ultrasound to evaluate muscle structure [ 51 ] and near infra-red spectroscopy (NIRS) to characterize muscle oxidative potential as a proxy for mitochondrial capacity [ 52 ]. Increasing age is also correlated with poorer STS test performance as it may represent progressive diminishing muscle quality over time [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Performance on sit-to-stand tests in relation to measures of functional fitness and sarcopenia diagnosis in community-dwelling older adults

Yee

Allen

et al. 2021

Eur Rev Aging Phys Act

107

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Background The sit-to-stand (STS) test has been deployed as surrogate measures of strength or physical performance in sarcopenia diagnosis. This study examines the relationship of two common STS variants – Five Times Sit-to-Stand Test (5TSTS) and 30 s Chair Stand Test (30CST) – with grip strength, muscle mass and functional measures, and their impact on sarcopenia prevalence in community-dwelling older adults. Methods This is a cross-sectional analysis of 887 community-dwelling adults aged ≥50 years. Participants completed a battery of physical fitness tests - 5TSTS, 30CST, grip strength, gait speed, Timed-Up-and-Go (TUG) for dynamic balance and six-minute walk test (6MWT) for cardiorespiratory endurance. Muscle mass was measured using multi-frequency segmental bioelectrical impedance analysis (BIA). We performed correlation analysis between STS performance and other fitness measures and muscle mass, followed by multiple linear regression for the independent determinants of STS performance. Results Mean participant age was 67.3±7 years, with female predominance (72.9%). STS tests exhibited weak correlations with grip strength (30CST, r = 0.290; 5TSTS, r = − 0.242; both p< 0.01), and stronger correlations with gait speed (30CST, r = 0.517; 5TSTS, r = − 0.533; both p< 0.01), endurance (30CST, r = 0.558; 5TSTS, r = − 0.531; both p < 0.01) and dynamic balance (30CST, r = − 0.501; 5TSTS, r = 0.646; both p< 0.01). Muscle mass correlated with grip strength but not STS. In multiple regression analysis, all fitness measures were independently associated with 30CST performance. Performance in both STS tests remained independent of muscle mass. There was no significant difference in prevalence of possible sarcopenia diagnosis using grip strength or STS (30CST, 25.0%; 5TSTS, 22.1%; grip strength, 22.3%; p = 0.276). When both measures are used, prevalence is significantly higher (42.0%; p = 0.276). Prevalence of confirmed sarcopenia with inclusion of muscle mass was significantly lower using STS compared with grip strength (30CST, 4.6%; 5TSTS, 4.1% vs. grip strength, 7.1%; p< 0.05). Conclusion In the sarcopenia construct, STS tests better represents muscle physical performance rather than muscle strength. Different subsets of population with possible sarcopenia are identified depending on the test used. The lack of association of STS performance with muscle mass results in a lower prevalence of confirmed sarcopenia compared with grip strength, but may better reflect changes in muscle quality.

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Section: Discussionmentioning

confidence: 99%

Performance on sit-to-stand tests in relation to measures of functional fitness and sarcopenia diagnosis in community-dwelling older adults

Yee

Allen

et al. 2021

Eur Rev Aging Phys Act

107

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“…With the progression of aging there is a loss of muscle mass and strength, this relationship is mainly explained by the gradual atrophy and loss of muscle fibers (Larsson et al, 2019). A case-control study, with older people aged ≥ 65 years, reported that individuals aged over 85 years had a higher risk of developing sarcopenia compared to those aged under 85 years, and this risk increased in relation to older people with a lower age, aged between 65 and 74 years (Safonova & Glazunova, 2020).…”

Section: Discussionmentioning

confidence: 99%

Conditions associated with sarcopenia and sarcopenic obesity among community-dwelling older people

Lira

Viana

Araújo

et al. 2021

RSD

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Objective: to investigate the factors associated with sarcopenia and sarcopenic obesity (SO) in community-dwelling older people. Methods: This was a cross-sectional community-based study. Sarcopenia was diagnosed according to the cutoff points of hand grip strength (HGS), and SO was identified through a low HGS concomitant with a high body fat percentage, according to sex, determined using electrical bioimpedance. Calorie and protein intake was estimated using a 24-hour recall. Socio-demographic data were obtained by means of an interview and the level of physical activity was assessed using a specific instrument. Results: Prevalence of 43% and 19.6% were observed for sarcopenia and SO, respectively. Older people aged ≥ 70 years have a significantly higher risk for sarcopenia in 183% (PR = 2.83; 95% CI = [1.62 to 4.96]; p value < 0.001) compared to those aged 60 to 69 years. The prevalence of sarcopenia was higher in males, among those who contribute to family support, present comorbidities and are less physically active. The prevalence of SO and sarcopenia was high, but this study did not allow us to observe statistically significant associations. Calorie and protein intakes were predominantly inadequate throughout the sample, however, there was no association with sarcopenia and SO. Conclusion: Advance years of life was shown to be a factor associated with sarcopenia, and with SO. Contributing to family support and insufficient physical activity were determining conditions for the occurrence of sarcopenia.

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A New Screening Method for the Diagnosis of Sarcopenia in People 65 Years and Older

Сафонова,

Клиценко

2023

Успехи Геронтологии

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Диагностика саркопении на сегодняшний день представляет определенные трудности. Для выявления последней в общей врачебной практике необходимо разработать простую, экономически эффективную, неинвазивную и достаточно точную модель, обладающую высокой диагностической ценностью. Цель исследования — разработка нового скринингового метода диагностики саркопении на основе изученных факторов и биомаркеров заболевания. В исследование были включены 230 человек 65 лет и старше (70 мужчин и 160 женщин, медиана возраста — 75 [68; 79] лет), которые обратились за консультативной помощью в медицинское учреждение Санкт-Петербурга. Данную патологию диагностировали по критериям Европейской рабочей группы по изучению саркопении 2-го пересмотра (EWGSOP2, 2018). Наибольшей диагностической значимостью саркопении при построении модели обладали такие показатели, как число падений, ИМТ, усталость и уровень С-реактивного белка в сыворотке крови. Расчет эффективности скринингового метода диагностики саркопении у людей 65 лет и старше показал ее высокую чувствительность — 91,4 %, специфичность — 88,7 %, точность — 89,9 %. Diagnosis of sarcopenia is difficult due to the limitations of measuring muscle mass, which requires specialized equipment. Simple screening tools can be useful in general practice. The aim of the study was to develop a new screening method for diagnosing sarcopenia based on risk factors and biomarkers of the disease. The study included 230 people over 65 years and older (70 men and 160 women, median age 75 [68; 79] years) examined in a medical institution in St. Petersburg. Sarcopenia was diagnosed according to the updated consensus of the European Working Group on Sarcopenia 2 (EWGSOP2, 2018). When constructing a mathematical model, such indicators as the number of falls, BMI, fatigue, and the level of C-reactive protein in the blood serum had the greatest diagnostic significance of sarcopenia. The calculations showed high sensitivity — 91,4 %, specificity — 88,7 % and accuracy — 89,9 % of the screening method for diagnosing sarcopenia in people 65 years and older.

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Diagnostic Criteria and Prevalence of Sarcopenia in the Elderly

Cited by 3 publications

References 26 publications

Performance on sit-to-stand tests in relation to measures of functional fitness and sarcopenia diagnosis in community-dwelling older adults

Performance on sit-to-stand tests in relation to measures of functional fitness and sarcopenia diagnosis in community-dwelling older adults

Conditions associated with sarcopenia and sarcopenic obesity among community-dwelling older people

A New Screening Method for the Diagnosis of Sarcopenia in People 65 Years and Older

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