Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia

Lazzaro, Vincenzo Di; Bella, Rita; Benussi, Alberto; Bologna, Matteo; Borroni, Barbara; Capone, Fioravante; Chen, Kai Hsiang S.; Chen, Robert; Chistyakov, Andrei V.; Claßen, Joseph; Kiernan, Matthew C.; Koch, Giacomo; Lanza, Giuseppe; Lefaucheur, Jean Pascal; Matsumoto, Hideyuki; Nguyen, Jean Paul; Orth, Michael; Pascual‐Leone, Álvaro; Rektorová, Irena; Šimko, Patrik; Taylor, John‐Paul; Tremblay, Sara; Ugawa, Yoshikazu; Dubbioso, Raffaele; Ranieri, Federico

doi:10.1016/j.clinph.2021.05.035

Cited by 105 publications

(106 citation statements)

References 487 publications

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“…using transcranial Doppler ( Vinciguerra et al, 2019 ) or arterial spin labeling MRI ( van den Brink et al, 2021 ), and brain plasticity and reserve (e.g. using transcranial magnetic stimulation ( Di Lazzaro et al, 2021 ), functional or structural connectivity measures ( Santonja et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Biesbroek

Weaver

Aben

et al. 2022

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Biesbroek

Weaver

Aben

et al. 2022

NeuroImage: Clinical

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“…Facilitatory circuits were evaluated by the intracortical facilitation (ICF) and the short-interval intracortical facilitation (SICF) protocols, while inhibitory circuits by SICI, long-interval intracortical inhibition (LICI) and CSP. 27 …”

Section: Methodsmentioning

confidence: 99%

Abnormal sensorimotor cortex and thalamo-cortical networks in familial adult myoclonic epilepsy type 2: pathophysiology and diagnostic implications

Dubbioso

Striano

Tomasevic

et al. 2022

Brain Communications

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Familial Adult Myoclonic Epilepsy type 2 is a hereditary condition characterized by cortical tremor, myoclonus, and epilepsy. It belongs to the spectrum of cortical myoclonus and the sensorimotor cortex hyperexcitability represents an important pathogenic mechanism underlying this condition. Besides pericentral cortical structures, the impairment of subcortical networks seems also to play a pathogenetic role, mainly via the thalamo-cortical pathway. However, the mechanisms underlying cortical-subcortical circuits dysfunction, as well as their impact on clinical manifestations, are still unknown. Therefore, the main aims of our study were to systematically study with an extensive electrophysiological battery the cortical sensorimotor as well as thalamo-cortical networks in genetically confirmed Familial Adult Myoclonic Epilepsy patients and to establish reliable neurophysiological biomarkers for the diagnosis. In 26 Familial Myoclonic Epilepsy subjects, harbouring the intronic ATTTC repeat expansion in the StAR-related lipid transfer domain-containing 7 gene, 17 Juvenile Myoclonic Epilepsy patients and 22 healthy controls, we evaluated the facilitatory and inhibitory circuits within the primary motor cortex using single and paired-pulse transcranial magnetic stimulation paradigms. We also probed the excitability of the somatosensory as well as the thalamo-somatosensory cortex connection by using ad hoc somatosensory evoked potential protocols. The sensitivity and specificity of transcranial magnetic stimulation and somatosensory evoked potential metrics were derived from receiver operating curve analysis. Familial Adult Myoclonic Epilepsy patients displayed increased facilitation and decreased inhibition within the sensorimotor cortex compared with Juvenile Myoclonic Epilepsy patients (all p< 0.05) and healthy controls (all p< 0.05). Somatosensory evoked potential protocols also displayed a significant reduction of early high-frequency oscillations and less inhibition at paired-pulse protocol, suggesting a concomitant failure of thalamo-somatosensory cortex circuits. Disease onset and duration, and myoclonus severity did not correlate either with sensorimotor hyperexcitability or thalamo-cortical measures (all p> 0.05). Patients with a longer disease duration had a more severe myoclonus (r= 0.467, p= 0.02) associated with a lower frequency (r= -0.607, p= 0.001) and higher power of tremor (r= 0.479, p= 0.02). Finally, Familial Adult Myoclonic Epilepsy was reliably diagnosed using transcranial magnetic stimulation, demonstrating its superiority as a diagnostic factor compared to somatosensory evoked potential measures. In conclusion, sensorimotor cortical and thalamo-cortical circuits are involved in the pathophysiology of Familial Adult Myoclonic Epilepsy even if these alterations are not associated with clinical severity. Transcranial magnetic stimulation-based measurements display an overall higher accuracy than somatosensory evoked potential parameters to reliably distinguish Familial Adult Myoclonic Epilepsy from Juvenile Myoclonic Epilepsy and healthy controls.

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“…Non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, are widely used to functionally investigate the neural pathways and brain network in vivo, also providing prognostic measures and neuromodulatory activity [ 94 , 95 , 96 , 97 , 98 , 99 , 100 ]. Accordingly, the data from EEG and functional neuroimaging, during both wakefulness and sleep, have suggested the involvement of different transmission systems which seem to be impaired in synucleinopathy, including PD, multiple system atrophy, and DLB [ 101 , 102 ].…”

Section: Other Neurophysiological Featuresmentioning

confidence: 99%

Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review

et al. 2021

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REM sleep without atonia (RSWA) is the polysomnographic (PSG) hallmark of rapid eye movement (REM) sleep behavior disorder (RBD), a feature essential for the diagnosis of this condition. Several additional neurophysiological aspects of this complex disorder have also recently been investigated in depth, which constitute the focus of this narrative review, together with RSWA. First, we describe the complex neural network underlying REM sleep and its muscle atonia, focusing on the disordered mechanisms leading to RSWA. RSWA is then described in terms of its polysomnographic features, and the methods (visual and automatic) currently available for its scoring and quantification are exposed and discussed. Subsequently, more recent and advanced neurophysiological features of RBD are described, such as electroencephalography during wakefulness and sleep, transcranial magnetic stimulation, and vestibular evoked myogenic potentials. The role of the assessment of neurophysiological features in the study of RBD is then carefully discussed, highlighting their usefulness and sensitivity in detecting neurodegeneration in the early or prodromal stages of RBD, as well as their relationship with other proposed biomarkers for the diagnosis, prognosis, and monitoring of this condition. Finally, a future research agenda is proposed to help clarify the many still unclear aspects of RBD.

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Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia

Cited by 105 publications

References 487 publications

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Abnormal sensorimotor cortex and thalamo-cortical networks in familial adult myoclonic epilepsy type 2: pathophysiology and diagnostic implications

Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review

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