Diagnostic Change From Atypical Intraepidermal Melanocytic Proliferation to Melanoma is More Likely When Clinically Visible Residual Pigment Remains After Biopsy

Jew, Olivia S.; Miller, Christopher J.; Shin, Thuzar M.; Sobanko, Joseph F.; Etzkorn, Jeremy R.

doi:10.1097/dss.0000000000001387

Cited by 4 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study revealed nearly all characteristics associated with melanoma/MIS diagnosis to remain significant after controlling for partial biopsy, diverging from a recent analysis of head/neck, hand, and foot AIMP biopsies in which partial biopsy was the only clinicopathologic factor associated with post-excision melanoma/MIS. 4 These other clinical characteristics may thus remain useful to prognosticate greater or lower melanoma/MIS odds even for full lesion biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…We aim to elucidate AIMP ontology and to add data to a growing body of dermatologic and dermatopathologic literature describing surgical outcomes of ambiguous melanocytic lesions. [2][3][4] We report the percentage of AIMP biopsies with post-excision melanoma/MIS diagnoses, describe clinical and histopathologic biopsy characteristics associated with this outcome, and evaluate the margins used for complete AIMP excision. This data will aid in patient counseling and surgical planning for AIMP.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis

Blank

Hibler

Tattersall

et al. 2019

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor "atypical intraepidermal melanocytic proliferation" (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in-situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 (OR 8.1, 95% CI 2.5-26.2), age ≥80 (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average surgical margin used to excise AIMP lesions was 4.5mm (SD 1.8).

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis

Blank

Hibler

Tattersall

et al. 2019

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

show abstract

“…Jew et al 14 described that 20.3% of AIMP diagnosed by incisional biopsies had a postoperative diagnostic change to melanoma. Zhang et al 1 also reported that a high percentage of lesions diagnosed as AIMP on a biopsy and excised afterward were MIS (up to 20%).…”

Section: Discussionmentioning

confidence: 99%

“…Jew et al 14 . described that 20.3% of AIMP diagnosed by incisional biopsies had a postoperative diagnostic change to melanoma.…”

Section: Discussionmentioning

confidence: 99%

Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ

et al. 2021

View full text Add to dashboard Cite

Background Atypical intraepidermal melanocytic proliferations (AIMP) is a descriptive term sometimes applied to biopsies that do not fulfill diagnostic criteria of melanoma. They are common on sun-damaged skin, but their definition and management are controversial.Objective To describe dermoscopic (DS), reflectance confocal microscopic (RCM) and histopathological features of AIMP and identify features associated with subsequent melanoma in situ (MIS). Methods A retrospective analysis of AIMP lesions correlated with patient outcome at two melanoma tertiary centers between 2005 and 2015. Results Thirty-four patients were included. Nine (26%) patients had MIS in subsequent biopsies. Predictors of later MIS were target-like pattern (OR:12.0 [CI: 1.23, 117.41]; P = 0.032) and high-density vascular network (OR:12 [CI: 1.23-117.41], P: 0.032) on DS, and presence of dendritic cells touching each other (OR:9.1 [CI: 1.54, 54.59], P = 0.014) on RCM. Clinical predictors of worse outcome included a previous history of MIS at the same site. Radiotherapy for AIMP had a high failure rate (all patients presented with recurrent disease, three as AIMP and two as MIS).Conclusions Considering that most cases in this series received non-surgical treatment at baseline, we recommend close monitoring for lesions with target-like pattern and density vascular network on DS and treatment for lesions with progression of atypia and/or with "confluent" dendritic cells on RCM. Although the number of patients in this series is very low, early surgery is recommended for MIS cases that recur as AIMP.

show abstract

“…Recently, residual pigment after biopsy has been established as a risk factor for change of AIMP to MIS or melanoma. 7 In that study, photographs before Mohs micrographic surgery of 118 AIMP lesions located in head, neck, hands, and feet were examined. Subtotal biopsy was proposed as the probable reason residual pigment was a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Defining the Histopathological Term Atypical Intraepidermal Melanocytic Proliferation: A Retrospective Cross-Sectional Study

Bou-Prieto

Sarriera-Lazaro²,

Valentín-Nogueras³

et al. 2020

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Background: Atypical intraepidermal melanocytic proliferation (AIMP) is a general term assigned to melanocytic proliferations of uncertain biological potential when a definitive histopathological diagnosis cannot be achieved. There are few data available describing the possibility of malignancy of AIMP, or ways to further define diagnosis.Objective: To determine the rate of diagnostic change of AIMP to melanoma or melanoma in situ (MIS) after conventional excision. In addition, to determine the role of immunohistochemistry (IHC) in defining AIMP biopsies.Methods: Retrospective cross-sectional, single-center review of biopsies with a diagnosis of AIMP with a follow-up conventional excision from 2012-2016 was performed. In a separate analysis, a search was performed for AIMP biopsied lesions in which IHC was subsequently performed. Results:The rate of diagnostic change of AIMP to MIS was 4.8% (8/167) after excision. Punch biopsy was a risk factor for diagnostic change to MIS (odds ratio 12.94, confidence interval 2.56-65.38, P = 0.008). The rate of diagnostic change of AIMP biopsies after examining with IHC was 21.3% (34/160) to MIS and 4.4% (7/ 160) to melanoma. Conclusion:The possibility of malignancy of AIMP lesions must be taken into consideration when counseling patients and when planning treatment options. IHC is a useful tool and should be used in the evaluation of AIMP specimens.

show abstract

Diagnostic Change From Atypical Intraepidermal Melanocytic Proliferation to Melanoma is More Likely When Clinically Visible Residual Pigment Remains After Biopsy

Cited by 4 publications

References 4 publications

Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis

Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis

Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ

Defining the Histopathological Term Atypical Intraepidermal Melanocytic Proliferation: A Retrospective Cross-Sectional Study

Contact Info

Product

Resources

About