Abstract:Context.—
Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography–guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. This often poses diagnostic challenges because of the complexity of the mediastinal anatomic structures. Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions a… Show more
“…MYST is usually positive for LIN28, SALL4, Glypican-3, AFP, and PLZF, variable for keratins and CD117, but negative for OCT4, CD30, PLAP, Nanog, beta-hCG, and CD10. [60][61][62] Mediastinal embryonal carcinoma (MEC) usually occurs concurrently with other GCT components instead of pure MEC. 55 FNA of MEC component may show clusters of or single large highly atypical epithelioid cells with large round vesicular nuclei and prominent nucleoli (Fig.…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…Mitosis and tumor necrosis are frequent. MEC is usually positive for keratins, OCT4, LIN28, SALL4, Nanog, variable for CD30, but negative for CD117, PLAP, AFP, Glypican-3, PLZF, beta-hCG, and CD10 62…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…Mitosis, hemorrhage, and necrosis are frequent. Mediastinal choriocarcinoma is positive for keratins, LIN28, SALL4, PLAP, beta-hCG, GATA3, and CD10, variable for Glypican-3, but negative for CD117, OCT4, CD30, Nanog, AFP, and PLZF 62…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…MEC is usually positive for keratins, OCT4, LIN28, SALL4, Nanog, variable for CD30, but negative for CD117, PLAP, AFP, Glypican-3, PLZF, beta-hCG, and CD10. 62 Mediastinal choriocarcinoma is extremely rare. 60 FNA of mediastinal choriocarcinoma may show 2 populations of cells: syncytiotrophoblasts and cytotrophoblasts.…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…The Schiller-Duval body is rare in cytologic preparation. MYST is usually positive for LIN28, SALL4, Glypican-3, AFP, and PLZF, variable for keratins and CD117, but negative for OCT4, CD30, PLAP, Nanog, beta-hCG, and CD10 60–62…”
Mediastinal fine needle aspirations are routinely encountered in cytopathology practice. Mediastinal lesions may pose diagnostic challenges owing to their rarity and locations associated with the complexity of the mediastinal anatomic structures in the thoracic cavity. Diagnosing mediastinal lesions and guiding patient management usually require correlating with clinical and radiologic findings, being familiar with cytomorphologic features and appropriately triaging the diagnostic material for ancillary testing. This review proposes a practical approach to interpret mediastinal fine needle aspirations and emphasizes potential diagnostic pitfalls for mediastinal lesions including benign cysts, thymic neoplasms, lymphoproliferative disorders, germ cell tumors, mesenchymal tumors, and metastatic tumors.
“…MYST is usually positive for LIN28, SALL4, Glypican-3, AFP, and PLZF, variable for keratins and CD117, but negative for OCT4, CD30, PLAP, Nanog, beta-hCG, and CD10. [60][61][62] Mediastinal embryonal carcinoma (MEC) usually occurs concurrently with other GCT components instead of pure MEC. 55 FNA of MEC component may show clusters of or single large highly atypical epithelioid cells with large round vesicular nuclei and prominent nucleoli (Fig.…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…Mitosis and tumor necrosis are frequent. MEC is usually positive for keratins, OCT4, LIN28, SALL4, Nanog, variable for CD30, but negative for CD117, PLAP, AFP, Glypican-3, PLZF, beta-hCG, and CD10 62…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…Mitosis, hemorrhage, and necrosis are frequent. Mediastinal choriocarcinoma is positive for keratins, LIN28, SALL4, PLAP, beta-hCG, GATA3, and CD10, variable for Glypican-3, but negative for CD117, OCT4, CD30, Nanog, AFP, and PLZF 62…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…MEC is usually positive for keratins, OCT4, LIN28, SALL4, Nanog, variable for CD30, but negative for CD117, PLAP, AFP, Glypican-3, PLZF, beta-hCG, and CD10. 62 Mediastinal choriocarcinoma is extremely rare. 60 FNA of mediastinal choriocarcinoma may show 2 populations of cells: syncytiotrophoblasts and cytotrophoblasts.…”
Section: Mediastinal Germ Cell Tumorsmentioning
confidence: 99%
“…The Schiller-Duval body is rare in cytologic preparation. MYST is usually positive for LIN28, SALL4, Glypican-3, AFP, and PLZF, variable for keratins and CD117, but negative for OCT4, CD30, PLAP, Nanog, beta-hCG, and CD10 60–62…”
Mediastinal fine needle aspirations are routinely encountered in cytopathology practice. Mediastinal lesions may pose diagnostic challenges owing to their rarity and locations associated with the complexity of the mediastinal anatomic structures in the thoracic cavity. Diagnosing mediastinal lesions and guiding patient management usually require correlating with clinical and radiologic findings, being familiar with cytomorphologic features and appropriately triaging the diagnostic material for ancillary testing. This review proposes a practical approach to interpret mediastinal fine needle aspirations and emphasizes potential diagnostic pitfalls for mediastinal lesions including benign cysts, thymic neoplasms, lymphoproliferative disorders, germ cell tumors, mesenchymal tumors, and metastatic tumors.
Rhabdomyosarcoma (RMS) is a common soft tissue malignant tumor, especially in young patients. Alveolar rhabdomyosarcoma (ARMS) is a subtype of RMS that is prevalent in adolescents. This malignant tumor usually develops in the extremities and can also involve the trunk, perineum, and pelvis. Now, we report a rare case of pelvic lymph node metastatic alveolar RMS in a young patient, which was determined by fine needle aspiration cytology (FNAC). To the best of our knowledge, this is the first case in which the definite diagnosis of ARMS was initially made by FNAC.
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