Diagnostic Capability and Reproducibility of Strain by Doppler and by Speckle Tracking in Patients With Acute Myocardial Infarction

Sjøli, Benthe; Ørn, Stein; Grenne, Bjørnar; Ihlen, Halfdan; Edvardsen, Thor; Brunvand, Harald

doi:10.1016/j.jcmg.2008.10.007

Cited by 121 publications

(99 citation statements)

References 20 publications

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“…Global longitudinal strain derived from a 16-segment model showed a good correlation with infarct size assessed by magnetic resonance imaging, with the best correlation being seen for global peak systolic speckle strain. Interestingly, circumferential strain assessed from the parasternal short-axis view divided into six segments was the best parameter to separate transmural from subendocardial necrosis (26).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly to the strain rate obtained from Doppler tissue imaging, the ability of the two-dimensional strain to differentiate between infarcted and noninfarcted myocardium was validated in a closed-chest swine model of MI (28). Recently, the ability of two-dimensional strain to predict infarct size in humans was compared with Doppler-derived strain performance in the acute phase of ST-segment MI (26). Global longitudinal strain derived from a 16-segment model showed a good correlation with infarct size assessed by magnetic resonance imaging, with the best correlation being seen for global peak systolic speckle strain.…”

Section: Discussionmentioning

confidence: 99%

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Speckle tracking imaging improves in vivo assessment of EPO-induced myocardial salvage early after ischemia-reperfusion in rats

Tréguer

Donal

Tamareille

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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A noninvasive assessment of infarct size and transmural extension of myocardial infarction (TEMI) is fundamental in experimental models of ischemia-reperfusion. Conventional echocardiography parameters are limited in this purpose. This study was designed to examine whether speckle tracking imaging can be used in a rat model of ischemia-reperfusion to accurately detect the reduction of infarct size and TEMI induced by erythropoietin (EPO) as early as 24 h after reperfusion. Rats were randomly assigned to one of three groups: myocardial infarction (MI)-control group, 45 min ischemia followed by 24 h of reperfusion; MI-EPO group, similar surgery with a single bolus of EPO administered at the onset of reperfusion; and sham-operated group. Short-axis two-dimensional echocardiography was performed after reperfusion. Global radial (GSr) and circumferential (GScir) strains were compared with infarct size and TEMI assessed after triphenyltetrazolium chloride staining. As a result, ejection fraction, shortening fraction, GSr, and GScir significantly correlated to infarct size, whereas only GSr and GScir significantly correlated to TEMI. EPO significantly decreased infarct size (30.8 Ϯ 3.5 vs. 56.2 Ϯ 5.7% in MI-control, P Ͻ 0.001) and TEMI (0.37 Ϯ 0.05 vs. 0.77 Ϯ 0.05 in MI-control, P Ͻ 0.001). None of the conventional echocardiography parameters was significantly different between the MI-EPO and MI-control groups, whereas GSr was significantly higher in the MI-EPO group (29.1 Ϯ 4.7 vs. 16.4 Ϯ 3.3% in MI-control; P Ͻ 0.05). Furthermore, GScir and GSr appeared to be the best parameters to identify a TEMI Ͼ0.75 24 h after reperfusion. In conclusion, these findings demonstrate the usefulness of speckle tracking imaging in the early evaluation of a cardioprotective strategy in a rat model of ischemia-reperfusion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Speckle tracking imaging improves in vivo assessment of EPO-induced myocardial salvage early after ischemia-reperfusion in rats

Tréguer

Donal

Tamareille

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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“…Furthermore, STE is able to assess the infarct size adding important diagnostic and prognostic information [20] . The study of both epicardial and endocardial border and the comparison between them could provide further information about the transmurality of myocardial infarction (Figure 2).…”

Section: B Amentioning

confidence: 99%

Speckle tracking echocardiography: A new approach to myocardial function

Sitia¹,

Tomasoni²,

Turiel

2010

WJC

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Echocardiography is the most common diagnostic method for assessing cardiac function but some limitations affect this technique. Until now, visual assessment of wall motion and thickening has allowed only a subjective evaluation of myocardial function and requires long-term training. Recently, new echocardiographic techniques have been introduced to evaluate myocardial mechanics. Tissue Doppler imaging (TDI) technique is limited by angle-dependency such that only deformation along the ultrasound beam can be derived from velocities, while myocardium deforms simultaneously in three dimensions. Speckle tracking echocardiography (STE) is a more recent technique that provides a global approach to left ventricular myocardial mechanics, giving information about the three spatial dimensions of cardiac deformation. In this editorial, we describe the physical and pathophysiological concepts of STE, discussing the differences compared to TDI and underlining the pitfalls of this new technique.

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“…However, the transfer function linking the local deformation to the tissue viability is complex, due to advanced physiological interactions between the muscle and the blood, the fibers arrangement, or the influence of the neighboring segments or the opposite wall. Late-enhancement imaging is generally accepted as ground truth to localize the regions with scarred tissue [8,9]. However, this modality is costly and requires the injection of a contrast agent.…”

Section: Introductionmentioning

confidence: 99%

“…Cardiologists use it in a daily practice to assess the local tissue viability. Nonetheless, the localization of infarct by thresholding deformation patterns [9] is inaccurate, as the optimal threshold depends on the infarct position and grade, and the relationship between these two parameters is not straightforward.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Infarct Localization from Myocardial Deformation

Duchateau¹,

Sermesant²

2016

Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges

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Abstract. We propose a novel framework to predict the location of a myocardial infarct from local wall deformation data. Non-linear dimensionality reduction is used to estimate the Euclidean space of coordinates encoding deformation patterns. The infarct location of a new subject is inferred by two consecutive interpolations, formulated as multiscale kernel regressions. They consist in (i) finding the low-dimensional coordinates associated to the measured deformation pattern, and (ii) estimating the possible infarct location associated to these coordinates. These concepts were tested on a database of 500 synthetic cases generated from a realistic electromechanical model of the two ventricles. The database consisted of infarcts of random extent, shape, and location overlapping the whole left-anterior-descending coronary territory. We demonstrate that our method is accurate and significantly overcomes the limitations of the clinically-used thresholding of the deformation patterns (average area under the ROC curve of 0.992±0.011 vs. 0.812±0.124, p<0.001).

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Diagnostic Capability and Reproducibility of Strain by Doppler and by Speckle Tracking in Patients With Acute Myocardial Infarction

Cited by 121 publications

References 20 publications

Speckle tracking imaging improves in vivo assessment of EPO-induced myocardial salvage early after ischemia-reperfusion in rats

Speckle tracking imaging improves in vivo assessment of EPO-induced myocardial salvage early after ischemia-reperfusion in rats

Speckle tracking echocardiography: A new approach to myocardial function

Prediction of Infarct Localization from Myocardial Deformation

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