Diagnostic and Therapeutic Challenges of Childhood Brucellosis in a Nonendemic Country

Shen, Min

doi:10.1542/peds.2007-1874

Cited by 48 publications

(38 citation statements)

References 34 publications

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“…Ninety-five percent of the patients had a recent history of either travel to Mexico or ingestion of unpasteurized milk products from Mexico. Fever was an initial complaint in 80% of the patients, and 50% of the patients presented with arthritis (Shen, 2008).…”

Section: Epidemiology and Clinical Manifestations Of Human Brucellosismentioning

confidence: 99%

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

Godfroid

Scholz²,

Barbier

et al. 2011

Preventive Veterinary Medicine

346

312

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Section: Epidemiology and Clinical Manifestations Of Human Brucellosismentioning

confidence: 99%

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

Godfroid

Scholz²,

Barbier

et al. 2011

Preventive Veterinary Medicine

346

312

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“…Daha az sıklıkta eklem şişliği-ağrısı ve karın ağrısı ile karşılaşıldı. Literatürde en sık başvuru şikâyeti ateş olmasına rağmen (13,(18)(19)(20) bizim çalışmamızda en sık başvuru şikâyeti halsizlik (%100), kas ağrısı (% 100) ve kilo kaybı (% 86) idi. Bu neticeler hastaların belki de en çok rahatsız oldukları şikâyet ile hastaneye başvurmaları ile ilgili olabilir.…”

Section: Minimumunclassified

“…ESR, CRP ve aminotransferazlarda artış çalışmamızda test edilen vakalarda sırasıyla %55 (n=24), %72 (n=31) ve %65 (n=28)'sinde saptandı. Bu testlerin hiçbiri özgül olmayıp, tanı koydurucu değildir (2,20).…”

Section: Minimumunclassified

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The evaluation of brucellosis in children in an endemic region of Turkey, Van

Sarı¹,

Sarı²,

Say³

et al. 2013

Gaziantep Med J

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ÖzetBruselloz özellikle ülkemizin doğu ve güneydoğu kesimlerinde endemik olarak görülen önemli bir enfeksiyon hastalığıdır. Bu makalede çocuklarda brusellozun klinik ve laboratuvar bulgularının ve tedavi sonuçlarının etkinliğini değerlendirmek amaçlandı.Eylül 2010 ile Şubat 2011 tarihleri arasında yaklaşık 6 aylık dönemde çocuk polikliniğine bruselloz düşündüren şikayetlerle başvuran çocuklar tetkik edildi. Tetkik edilen hastaların 43'üne bruselloz tanısı konuldu ve başvuru şikayetleri, fizik muayene bulguları ve laboratuvar sonuçları değerlendirildi. Olguların 22'si erkek (%51) olup ortalama yaşları 9.3 yaş (4 yaş-13 yaş) arasında idi. En sık başvuru yakınmaları; halsizlik olguların tamamı (%100), kas ağrısı olguların tamamı (%100) ve kilo kaybı (%86) idi. Olguların fizik muayenelerinde; artrit (%48), lenfadenopati (%6) ve splenomegali (%13) saptandı. Laboratuvar bulgularında olguların %51'inde sedimantasyon yüksekliği, %65'inde ALT/AST yüksekliği ve %72'sinde ise CRP pozitifliği vardı. Brusella aglütinasyon testleri olguların tamamında pozitifti. Kan kültüründe üreme olguların %6'sında tespit edildi. Olguların tamamına en az ikili antibiyotik tedavisi verildi. Rölaps %11 (n=5) oranında görüldü, mortalite gözlenmedi. Bruselloz özellikle hastalığın yaygın olduğu bölgelerde sağlık ekiplerinin üzerinde durması gereken ve koruyucu tedbirlerin alınması ve etkin tedavinin uygulanması gereken toplum sağlığı problemidir. Anahtar kelimeler: Bruselloz; çocuk; laboratuvar bulguları; tedavi. AbstractBrucellosis is an important infectious disease especially endemic in Eastern and Southeastern Turkey. In this study, we aimed to evaluate the clinical, laboratory and treatment results of Brucellosis in children. Children with nonspecific findings suggestive of Brucellosis were included from September 2010 to February 2011 from the outpatient clinic. The symptoms, physical findings and laboratory values are analyzed in 43 children who were diagnosed as Brucellosis.The mean age of children was 9.3 years (range: 4-13 years), 51%n:22) were male. Most common complaint was fatigue (100%), myalgia (100%) and weight loss (86%). Arthritis (48%), lymphadenopathy (6%), and splenomegaly (13%) has been identified. Laboratory values revealed high sedimentation rates (51%), high AST/ALT (65%), high CRP levels (72%). Brucella agglutination test was positive in all of the patients. Brucella was identified in 6% of blood cultures. All of the patients were treated with antibiotics of least two-drug combination. The relapse rate was 11% (n=5) and no mortality was observed. Brucellosis is an important health issue, especially in endemic regions, necessitating preventive measures and effective treatment.

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“…There is decrease in nausea, fatigue, inappetit with the development of jaundice. If the patient has fever, it decreases within few days (8,9). Nausea, vomiting, diarrhea, constipation, jaundice and nonspecific gastrointestinal system observations such as stomachache as well as involvement of liver are observed in 70% of brucella cases (4).…”

Section: Discussionmentioning

confidence: 99%

Association of Acute Hepatitis a and Brucellosis in Two Cases

Bektaş¹

2014

AJCEM

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Several damage rate occurs in liver during acute infections according to the infection agent. The exposure of the patient to two different infection causes at the same time is another situation complicating the diagnosis of infectious diseases. Hepatitis A virus and brucella are two factors that are observed from the childhood in developing countries as ours and presenting different pattern. Serological tests are used to benefit from differential diagnosis. In this study, the cases of hepatitis A and brucella co-infection in spite of the different contamination ways has been presented.

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Diagnostic and Therapeutic Challenges of Childhood Brucellosis in a Nonendemic Country

Abstract: Childhood brucellosis in the United States is now an imported disease, primarily from Mexico. In the context of this epidemiologic link, the diagnosis should be entertained for a patient who presents with signs of systemic inflammation and arthritis. Therapeutic challenges remain.

Cited by 48 publications

References 34 publications

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

The evaluation of brucellosis in children in an endemic region of Turkey, Van

Association of Acute Hepatitis a and Brucellosis in Two Cases

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