Diagnostic and Therapeutic Approach to Arrhythmias in Adult Congenital Heart Disease

Guerrier, Karine; Hendrickson, Benjamin; Waller, B. Rush; Wetzel, Glenn T.

doi:10.1007/s11936-019-0749-9

Cited by 4 publications

(3 citation statements)

References 106 publications

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“…The incidence of AT in patients with congenital heart disease (CHD) is three times that in the general population, and 42% of structural heart disease is complicated with MAT ( 3 ). Furthermore, the morbidity of atrial arrhythmia is increased with aging and the complexity of CHD, both of which predict adverse outcomes of AT, such as heart failure, death, and intervention ( 7 ). Because of early diagnosis and early surgery, the prognosis of patients with CHD has greatly improved in recent decades.…”

Section: Etiology Of Mat At Different Periods Of Growthmentioning

confidence: 99%

“…In previous studies, the main etiologies of MAT are gestational disease, Costello syndrome, congenital heart disease, post-cardiac surgery, cardiac anatomic abnormality, pulmonary arterial hypertension, and infectious diseases. Although the prognosis of pediatric MAT is favorable in most patients, adverse outcomes of MAT have been reported in some children, particularly the patients who are accompanied by HRAS, RYR2, RAF1, and RAS gene mutation ( 5 , 7 ). The adverse outcomes of MAT include cardiogenic death (3%), respiratory failure (6%), or persistent arrhythmia (7%).…”

Section: Introductionmentioning

confidence: 99%

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Progress of Pathogenesis in Pediatric Multifocal Atrial Tachycardia

Chen

Wang

et al. 2022

Front. Pediatr.

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Multifocal atrial tachycardia (MAT) is defined as irregular P-P, R-R, and P-R intervals, isoelectric baseline between P waves, and ventricular rate over 100 beats/min. Although the prognosis of pediatric MAT in most patients is favorable, adverse outcomes of MAT have been reported, such as cardiogenic death (3%), respiratory failure (6%), or persistent arrhythmia (7%), due to delayed diagnosis and poorly controlled MAT. Previous studies demonstrated that pediatric MAT is associated with multiple enhanced automatic lesions located in the atrium or abnormal automaticity of a single lesion located in the pulmonary veins via multiple pathways to trigger electrical activity. Recent studies indicated that pediatric MAT is associated with the formation of a re-entry loop, abnormal automaticity, and triggering activity. The occurrence of pediatric MAT is affected by gestational disease, congenital heart disease, post-cardiac surgery, pulmonary hypertension, and infectious diseases, which promote MAT via inflammation, redistribution of the autonomic nervous system, and abnormal ion channels. However, the pathogenesis of MAT needs to be explored. This review is aimed to summarize and analyze the pathogenesis in pediatric MAT.

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Section: Etiology Of Mat At Different Periods Of Growthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Progress of Pathogenesis in Pediatric Multifocal Atrial Tachycardia

Chen

Wang

et al. 2022

Front. Pediatr.

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“…20 Since the entire S-ICD system is implanted in an extra-thoracic space, it eliminates the complications related to endo-or epicardial leads. 21 The ACHD patients with no transvenous access to the heart (namely Fontal palliation), or those with a right-to-left shunt and increased risk of systemic emboli, can attain the utmost potential benefit 22 from implantation of S-ICD. Unfortunately, our study demonstrated that 40% of the contemporary complex ACHD population is ineligible for S-ICD.…”

Section: Nearly Half Of the Contemporary Achd Population Is Ineligible For S-icdmentioning

confidence: 99%