Diagnostic and prognostic value of a novel cardiac calcification score for coronary artery disease by transthoracic echocardiography

Hirschberg, Kristóf; Reinhart, Manuel; Konstandin, Mathias; Uhlmann, Lorenz; Katus, Hugo A.; Mereles, Derliz

doi:10.1016/j.ijcard.2015.04.153

Cited by 6 publications

(8 citation statements)

References 10 publications

(3 reference statements)

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“…In fact, it has been found that a calcium score easily obtainable during standard echocardiography, is moderately to strongly (Spearman’s rho = 0.64) correlated with noncoronary calcium score by CT and that the two techniques had similar area under the curve (AUC = 0.77) for the prediction of severe CACs (>400). While this study only found a moderate correlation between the echo score and CACs, the study conducted by Hirschberg et al [ 80 ] observed a good Spearman’s correlation (0.73). This means that about 50% of the variability of the CACs depends on the variability of the echo score.…”

Section: How To Detect Cardiac Calcification?contrasting

confidence: 60%

“…A new echocardiographic calcification score “echoCCS” [ 80 , 81 ] ( Table 1 ) proved its value as an independent predictor for significant CAD and for all-cause mortality in patients with a high and low/intermediate CV risk profile. The main difference from the other scores is that a fifth cardiac structure, the ventricular septum, is systematically evaluated for the presence or absence of calcification beyond the aortic valve, the aortic root, the mitral annulus and the papillary muscles.…”

Section: How To Detect Cardiac Calcification?mentioning

confidence: 99%

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Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography

Faggiano

Santangelo

Carugo

et al. 2021

JCM

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The risk prediction of future cardiovascular events is mainly based on conventional risk factor assessment by validated algorithms, such as the Framingham Risk Score, the Pooled Cohort Equations and the European SCORE Risk Charts. The identification of subclinical atherosclerosis has emerged as a promising tool to refine the individual cardiovascular risk identified by these models, to prognostic stratify asymptomatic individuals and to implement preventive strategies. Several imaging modalities have been proposed for the identification of subclinical organ damage, the main ones being coronary artery calcification scanning by cardiac computed tomography and the two-dimensional ultrasound evaluation of carotid arteries. In this context, echocardiography offers an assessment of cardiac calcifications at different sites, such as the mitral apparatus (including annulus, leaflets and papillary muscles), aortic valve and ascending aorta, findings that are associated with the clinical manifestation of atherosclerotic disease and are predictive of future cardiovascular events. The aim of this paper is to summarize the available evidence on clinical implications of cardiac calcification, review studies that propose semiquantitative ultrasound assessments of cardiac calcifications and evaluate the potential of ultrasound calcium scores for risk stratification and prevention of clinical events.

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Section: How To Detect Cardiac Calcification?contrasting

confidence: 60%

Section: How To Detect Cardiac Calcification?mentioning

confidence: 99%

Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography

Faggiano

Santangelo

Carugo

et al. 2021

JCM

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“…Cardiac structures of the aortic valve, aortic root (Figure 1), mitral ring, papillary muscles and ventricular septum were evaluated for the presence or absence of calcification. Later, these values were collected, and the echocardiographic calcification scores were calculated to be between 0-5 [9]. Patients were classified according to their calcification score as follows: 0 (no calcification), echo-CSS 1-2 and echo-CSS >3.…”

Section: Transthoracic Echocardiographic Assessmentmentioning

confidence: 99%

“…A large population study has reported a positive association between incident arterial calcification and incident OA [8]. Calcifications evaluated on echocardiography are an important prognostic factor for coronary artery disease (CAD) and future CV events [9]. The echocardiographic calcification score (echo-CCS) has been an independent predictor for atherosclerosis, and it is associated with increased all-cause mortality in patients at high CV risk [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Calcifications evaluated on echocardiography are an important prognostic factor for coronary artery disease (CAD) and future CV events [9]. The echocardiographic calcification score (echo-CCS) has been an independent predictor for atherosclerosis, and it is associated with increased all-cause mortality in patients at high CV risk [9,10]. Very few studies have specifically investigated the association between knee OA (KOA) and echo-CCS [11].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis

Kivrak,

Yildirim,

Horoz

et al. 2023

Cureus

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Background and objectiveIt has been suggested that knee osteoarthritis (KOA) is associated with the development of calcification and an increased risk of cardiovascular (CV) disease, while the contribution of KOA grade is not clearly known enough. This study aimed to investigate the relationship between the grade of KOA, the echocardiographic calcification score (echo-CCS), and CV risk assessment. MethodsThis cross-sectional study involved 204 patients diagnosed with KOA and classified according to the Kellgren-Lawrence staging criteria. Echo-CCS was obtained according to the presence of calcification in the aortic valve, aortic root, mitral ring, papillary muscle and ventricular septum. Framingham risk score (FRS) was used for CV risk assessment. ResultsCalcification was detected in 79.4% of patients . The median FRS, echo-CCS, and high-sensitivity C-reactive protein (hs-CRP) levels increased as the KOA grade increased (p<0.05). A one-grade increase in KOA increased the odds of echo-CCS 1-2 group by 5.15 fold (vs. no calcification group) (OR=5.15, p=0.003), while it increased the odds of echo-CCS ≥3 group by 4.61 fold (vs. echo-CCS 1-2 group) (OR=4.61, p=0.003). Median echo-CSS and hs-CRP were higher in the high CV risk group than in the moderate and low CV risk groups. ConclusionThe majority of patients with KOA had intracardiac calcification. An increased KOA grade was associated with higher echo-CSS and FRS. These findings indicate that patients with higher grades of KOA may be predisposed to developing subclinical atherosclerosis.

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Echocardiographic calcification score in patients with low/intermediate cardiovascular risk

et al. 2018

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Diagnostic and prognostic value of a novel cardiac calcification score for coronary artery disease by transthoracic echocardiography

Cited by 6 publications

References 10 publications

Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography

Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography

The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis

Echocardiographic calcification score in patients with low/intermediate cardiovascular risk

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