Diagnostic and prognostic value of serum protein electrophoresis in horses with chronic diarrhoea

Mair, T. S.; Cripps, Peter; Ricketts, S. W.

doi:10.1111/j.2042-3306.1993.tb02973.x

Cited by 25 publications

(15 citation statements)

References 8 publications

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“…In small animal and equine medicine, indications for performing the serum protein electrophoresis have largely focused on the investigation of hyperproteinaemia, hepatic diseases, and screening for gammopathies and immunodeficiences (Mair et al, 1993;Tappin et al, 2011). on the other hand, there are only scarce data regarding the serum protein electrophoretic pattern in cattle with various organ diseases, and the studies were performed some years ago.…”

Section: Discussionmentioning

confidence: 99%

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Tóthová¹,

Nagy²,

Kováč³

2013

ACTA VET-BEOGRAD

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The aim of this study was to evaluate the serum proteins electrophoretic pattern and the concentrations of acute phase proteins in calves with chronic bronchopneumonia. Twenty-eight calves with clinical symptoms of disease were included into the evaluation. Blood serum was analyzed for total protein concentrations (TP), total and relative values of serum protein fractions, albumin/globulin ratio (A/G) and the concentrations of selected acute phase proteins -haptoglobin (Hp), serum amyloid A (SAA), and fibrinogen (Fbg). The results recorded in sick animals were compared with those in 36 clinically healthy calves as control group. In calves suffering from chronic bronchopneumonia we found significantly higher total serum protein concentrations than in healthy calves (p<0.001). In sick calves a marked shift in the concentrations of most of the protein fractions was observed, with significantly higher mean total values of α 1 -(p<0.001), β 1 -(p<0.01), β 2 -(p<0.001), and γ-globulins (p<0.001) and relative mean values of α 1 -(p<0.01), β 2 -(p<0.01), and γ-globulins (p<0.001). On the other hand, the concentrations of albumin and A/G ratios were in calves with respiratory diseases significantly lower than those measured in healthy ones (p<0.001). The mean concentrations of α 2 -globulins did not differ significantly between the two groups of animals. In the affected calves significantly higher mean values of Hp, SAA, as well as Fbg (p<0.001) were described. The presented results suggest a marked effect of chronic bronchopneumonia in calves on most of the evaluated protein profiles and acute phase protein variables with a marked shift in the albumin and globulin concentrations.

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Section: Discussionmentioning

confidence: 99%

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Tóthová¹,

Nagy²,

Kováč³

2013

ACTA VET-BEOGRAD

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“…Chronic persistent liver disease, liver cirrhosis, as well as nephrotic syndrome may cause elevations in the β-region due to the increase of the concentrations of β 2 -microglobulin in these conditions (Revillard 1980;Joven et al 1997). Higher concentrations of β 1 -globulins were found also in horses with larval cyathostomiasis (Kent 1987;Mair et al 1993). High β-globulin concentrations may be associated also with hypercholesterolemia, which is caused by an increased concentration of beta-lipoproteins in this fraction (Pagana and Pagana 2006).…”

Section: Globulinsmentioning

confidence: 99%

Serum proteins and their diagnostic utility in veterinary medicine: a review

Tóthová¹,

Nagy²,

Kováč³

2016

Vet. Med.

130

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ABSTRACT:The evaluation of serum proteins and their electrophoretic pattern is a well-established laboratory method in the diagnosis of many diseases in humans, which has replaced the biochemical determination of the concentrations of albumin and the ratio of albumin to globulins. The measurement of serum proteins may be an important diagnostic tool for the detection, diagnosis, and monitoring of various diseases and pathological processes. The results of serum protein electrophoresis can be one of the most useful diagnostic aids in a wide spectrum of diseases, including infectious and inflammatory diseases, renal or gastrointestinal disorders, immunodeficiency states, as well as paraproteinaemias caused by lymphoid or plasma cell neoplasia. Although many studies have been carried out to determine the usefulness of the determination of serum proteins and their electrophoretic pattern in various disease conditions and disorders also in animals, serum protein evaluation is still a relatively little-used diagnostic tool in veterinary medicine. In this article, methods of serum protein determination, their diagnostic utility in animal care practice and their different patterns in dysproteinaemias and paraproteinaemias are reviewed.

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“…In small animal and equine medicine, indications for performing the serum protein electrophoresis have largely centred on the investigation of hyperproteinaemia, hepatic diseases, and screening for gammopathies and immunodeficiences (Mair et al 1993, Tappin et al 2011. However, there are only scarce data regarding the serum protein electrophoretic pattern in cattle with various organ diseases (traumatic gastritis, gastro-phrenitis and traumatic peritonitis) (Yoshida 1986) and there is a lack of data regarding the serum electrophoretic pattern and changes in albumin and globulin fractions in cattle with respiratory diseases.…”

Section: Resultsmentioning

confidence: 99%

The serum protein electrophoretic pattern and acute phase protein concentrations in calves with chronic respiratory diseases

Tóthová

Nagy

Kováč

2013

Polish Journal of Veterinary Sciences

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The aim of this study was to evaluate the serum protein electrophoretic pattern and the concentrations of acute phase proteins (haptoglobin, serum amyloid A, and fibrinogen) in 28 calves with clinical signs of chronic respiratory diseases and 36 healthy calves as a control group. In sick calves we found significantly higher serum concentrations of total proteins (P<0.001), lower concentrations of albumin (P<0.001) and marked shift in the concentrations of the most of protein fractions with significantly higher values of α 1 -, β 1 -, β 2 -, and γ-globulins (P<0.001 and P<0.01). The affected calves had significantly higher values of haptoglobin, serum amyloid A, and fibrinogen as well (P<0.05, P<0.001 and P<0.001, respectively).

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Diagnostic and prognostic value of serum protein electrophoresis in horses with chronic diarrhoea

Cited by 25 publications

References 8 publications

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Serum proteins and their diagnostic utility in veterinary medicine: a review

The serum protein electrophoretic pattern and acute phase protein concentrations in calves with chronic respiratory diseases

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