Diagnostic and prognostic value of serum IL-23 in colorectal cancer

Elessawi, Dina F.; Alkady, Manal M; Ibrahim, Iman

doi:10.1016/j.ajg.2019.05.002

Cited by 15 publications

(6 citation statements)

References 33 publications

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“…The levels of IL-23 and IL-23R were found to be significantly higher in breast cancer tissues and positively correlated with the patient's tumor size, TNM stage and metastasis [90]. In colorectal cancer, the levels of IL-23 in patients' serum samples were found to gradually increase with tumor stage progression [91,92]. IL-23 could activate Th17, ILC3, granulocytes, NK cells and intra-epithelial lymphocytes, which exaggerated gut inflammation and promoted the growth of colon cancer [93].…”

Section: Il-23 In Cancer Immunotherapymentioning

confidence: 93%

IL-12 Family Cytokines in Cancer and Immunotherapy

Mirlekar

Pylayeva-Gupta

2021

Cancers

145

102

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The IL-12 family cytokines are a group of unique heterodimeric cytokines that include IL-12, IL-23, IL-27, IL-35 and, most recently, IL-39. Recent studies have solidified the importance of IL-12 cytokines in shaping innate and adaptive immune responses in cancer and identified multipronged roles for distinct IL-12 family members, ranging from effector to regulatory immune functions. These cytokines could serve as promising candidates for the development of immunomodulatory therapeutic approaches. Overall, IL-12 can be considered an effector cytokine and has been found to engage anti-tumor immunity by activating the effector Th1 response, which is required for the activation of cytotoxic T and NK cells and tumor clearance. IL-23 and IL-27 play dual roles in tumor immunity, as they can both activate effector immune responses and promote tumor growth by favoring immune suppression. IL-35 is a potent regulatory cytokine and plays a largely pro-tumorigenic role by inhibiting effector T cells. In this review, we summarize the recent findings on IL-12 family cytokines in the control of tumor growth with an emphasis primarily on immune regulation. We underscore the clinical implications for the use of these cytokines either in the setting of monotherapy or in combination with other conventional therapies for the more effective treatment of malignancies.

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Section: Il-23 In Cancer Immunotherapymentioning

confidence: 93%

IL-12 Family Cytokines in Cancer and Immunotherapy

Mirlekar

Pylayeva-Gupta

2021

Cancers

145

102

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“…Increasing values of IL-23 with cancer stages were observed [ 98 ]. IL-23 level was elevated in stages I, II, III, IV patients vs. control ( Table 1 ).…”

Section: Reviewmentioning

confidence: 99%

Systemic Interleukins’ Profile in Early and Advanced Colorectal Cancer

Czajka-Francuz

Cisoń-Jurek

Czajka

et al. 2021

IJMS

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Tumor microenvironment (TME) is characterized by mutual interactions of the tumor, stromal and immune cells. Early and advanced colorectal tumors differ in structure and present altered serum cytokine levels. Mutual crosstalk among TME infiltrating cells may shift the balance into immune suppressive or pro-inflammatory, antitumor response this way influencing patients’ prognosis. Cancer-related inflammation affects all the body and this way, the systemic level of cytokines could reflect TME processes. Despite numerous studies, it is still not known how systemic cytokines levels change during colorectal cancer (CRC) tumor development. Better understanding tumor microenvironment processes could help in planning therapeutic interventions and more accurate patient prognosis. To contribute to the comprehension of these processes within TME, we reviewed cytokines levels from clinical trials in early and advanced colorectal cancer. Presented data were analyzed in the context of experimental studies and studies analyzing tumor infiltration with immune cells. The review summarizes clinical data of cytokines secreted by tumor microenvironment cells: lymphocytes T helper 1 (Th1), lymphocytes T helper 2 (Th2), lymphocytes T helper 17 (Th17), regulatory T cells (Treg cells), regulatory T cells (Breg cells), M1/M2 macrophages, N1/N2 neutrophils, myeloid-derived suppressor cells (MDSC), dendritic cells (DC), innate lymphoid cells (ILC) natural killer (NK) cells and tumor cells.

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“…IL23A and IL12B transcripts are overexpressed in primary CRC tissues and the IL-23 serum level is elevated in CRC patients’ plasma, leading to an increased rate of metastasis via STAT5 pathway activation [ 30 , 133 ]. Recent studies showed that IL-23 overexpression correlates with tumor stage progression [ 175 ]. However, IL-23 serum levels did not correlate with tumor recurrence in patients after surgical treatment combined with chemotherapy [ 176 ].…”

Section: The Mediatory Role Of Interleukins In Colorectal Carcinogenesismentioning

confidence: 99%

The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review

et al. 2022

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The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their potential role in CRC pathogenesis and promising results of clinical trials. Malignant transformation is associated with the pro-tumorigenic and anti-tumorigenic cytokines. The harmony between proinflammatory and anti-inflammatory factors is crucial to maintaining homeostasis. Immune cells in the tumor microenvironment modulate immune sensitivity and facilitate cancer escape from immune surveillance. Therefore, clarifying the role of underlying cytokine pathways and the effects of their modulation may be an important step to improve the effectiveness of cancer immunotherapy.

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Diagnostic and prognostic value of serum IL-23 in colorectal cancer

Cited by 15 publications

References 33 publications

IL-12 Family Cytokines in Cancer and Immunotherapy

IL-12 Family Cytokines in Cancer and Immunotherapy

Systemic Interleukins’ Profile in Early and Advanced Colorectal Cancer

The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review

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