Diagnostic and prognostic value of the BEX family in lung adenocarcinoma

Abstract

Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atlas data and revealed that the BEX family was downregulated in LUAD tissues compared with adjacent non-cancerous tissues. Additionally, analysis of LUAD cohorts from the Oncomine database revealed similar results. Furthermore, the expression of BEX members was significantly decreased in several LUAD cell lines compared with normal lung epithelial cells in vitro. The aforementioned data mining and in vitro results suggested that the BEX family may be involved in the development of LUAD. Furthermore, receiver operating characteristic curve analysis revealed that BEX members exhibited high sensitivity and specificity for the diagnosis of patients with LUAD. The low expression levels of BEX1, BEX4 and BEX5 were associated with certain pathologic features, particularly in advanced LUAD. Survival analysis demonstrated that BEX members, particularly BEX4, were involved in the prognosis of patients with LUAD at early and late clinical stages. The results obtained in the current study suggested that BEX members may serve as potential tumor biomarkers for the diagnosis and prognosis of patients with LUAD.

CD8+ T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma

“…BEX5 , a member of the BEX family, is involved in various biological functions related to normal and tumor tissues ( 27 ). A previous study demonstrated that BEX5 mRNA levels are downregulated in LUAD tissues and have prognostic value ( 28 ). CD69, a C-type lectin receptor family member, is the earliest surface antigen expressed after T lymphocyte activation and acts as a co-stimulatory signal to promote further activation ( 29 , 30 ).…”

Targeting TFAP2C/PDCD6 Pathway by lncRNA PP7080 Expedites Tumorigenesis and Contributes to an Immunosuppressive Tumor Microenvironment in Non‐Small Cell Lung Cancer

“…[ 8 ] PDCD6 was also found to substantially expand in primary breast cancer tissues compared with para cancerous tissues, and it is correlated with lymph node metastasis and related to a low overall survival time. [ 9 ] Wang et al. demonstrated that PDCD6 collaborates with C‐Raf to facilitate colorectal cancer (CRC) progression through targeting Raf/MEK/ERK axis.…”

Transcription Elongation Factor A (SII) -Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

“…BEX family, containing BEX1, BEX2, BEX3, BEX4 and BEX5, had similar sequence and adjacent location with TCEAL family, which formed the BEX/TCEAL transcriptional regulator cluster [24]. BEX family proteins are known to play a role in neuronal development and recent studies suggest a role in cancers [25][26][27][28][29]. BEX1 suppressed tumor cell growth of esophageal squamous cell cancer, colorectal cancer, acute myeloid leukemia, oral squamous cell carcinoma, malignant glioma [30][31][32][33][34].…”