Diagnostic and prognostic value of presepsin in preterm deliveries

Abstract

Elevated maternal serum concentration of sCD14-ST could be an independent and relevant risk factor for preterm delivery.

Soluble CD14 subtype (sCD14-ST) presepsin in premature and full term critically ill newborns with sepsis and SIRS

“…Presepsin sCD14-ST reduces the mortality rate caused by endotoxin shock and the severity of Gram-negative bacterial infections; it is a regulatory factor capable of modulating cellular and humoral immune responses by interacting directly with T and B cells [18]. The potential clinical utility of sDC14-ST presepsin in discriminating septic patients has been reported both for adults and newborns [19][20][21][22], since it significantly increases in blood stream at the early stage of sepsis and inflammation. Thus, sCD14-ST was proposed as a reliable biomarker for the early diagnosis of sepsis [23,24].…”

Presepsin (sCD14-ST) as a biomarker of sepsis in clinical practice and in emergency department: a mini review

“…Elevated presepsin levels in maternal blood may be a risk factor for preterm delivery [18]. Topcuoglu et al [19] also proposed presepsin as an indicator of late-onset sepsis (LOS) and treatment response in preterm infants.…”