Presepsin (sCD14-ST) as a biomarker of sepsis in clinical practice and in emergency department: a mini review

Erenler, Ali Kemal; Yardan, Türker

doi:10.1515/labmed-2015-0072

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Procalcitonin levels do not increase or increase only slightly in non-bacterial inflammatory syndromes. Procalcitonin also provides prognostic information and risk stratification assessment in the emergency unit 17 . In our study, we determined that plasma levels of these two biomarkers elevate in both sepsis and severe sepsis.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Erenler¹,

Yapar²,

Terzi³

2017

Dicle Tıp Dergisi

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Objective: Sepsis and severe sepsis (sepsis accompanied by acute organ dysfunction) are leading causes of death worldwide. In this study, our aim was to investigate utility of biomarkers commonly used in diagnosis of sepsis in discriminating these two entities. Methods: Two-hundred and three patients involved were divided into 2 subgroups as sepsis and severe sepsis according to Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012. Then groups were compared according to clinical and laboratory (including C-reactive protein (CRP) and procalcitonin (PCT) levels) characteristics. Results: Of 203 patients included into the study, 124 (61.1%) were male and 79 (38.9%) were female. The most common reason for sepsis was urinary tract infection (n=64, 31.5%), followed by catheter infection (n=16, 7.9%) and pneumonia (n=14, 6.9%). Escherichia coli was the most common agent in both blood and urinary cultures. Majority of the patients were treated with ceftriaxone (n=33, 16.3%), followed by meronem/dapson (n=25, 12.3%). In both groups, CRP and PCT levels were high, even higher in severe sepsis group. However, any statistical significance could not be determined between groups. Mortality rate in sepsis patients was 6.4%. Conclusion: Plasma levels of both markers elevate in sepsis and severe sepsis. It was determined that CRP and PCT is higher in severe sepsis than in sepsis. However, the difference is not statistically significant. Plasma levels of CRP and PCT are not useful in differential diagnosis of sepsis and severe sepsis. Keywords: C-reactive protein, procalcitonin, sepsis, severe sepsis, Emergency department 176 Acil Serviste Sepsis ve Şiddetli Sepsisin Ayırıcı Tanısında Prokalsitonin ve C-reaktif Proteinin KarşılaştırılmasıÖzet Amaç: Sepsis ve şiddetli sepsis (akut organ disfonksiyonunun eşlik ettiği sepsis) dünyada ölümlerin başlıca nedenlerindendir. Bu çalışmada amacımız, sepsis tanısında sıkça kullanılan biyobelirteçlerin bu iki durumun ayrımındaki yararlılıklarını araştırmaktır. Yöntemler: Dahil edilen 203 hasta; Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012 kılavuzuna göre sepsis ve şiddetli sepsis olmak üzere iki gruba ayrılmıştır. Daha sonra gruplar klinik ve laboratuar (C-reaktif protein (CRP) ve prokalsitonin (PCT) dahil olmak üzere) özelliklerine göre karşılaştırılmıştır. Bulgular: Çalışmaya katılan 203 hastanın 124 (%61,1)'ü erkek, 79 (%38,9)'u kadındı. Sepsisin en sık nedeni üriner sistem enfeksiyonlarını (n=64, %31,5) takiben kateter enfeksiyonları (n=16, %7,9) ve pnömoni (n=14, %6,9) idi. Üriner ve kan kültürlerinde en sık ajan Escherichia coli olarak tespit edildi. Hastaların çoğu seftriakson (n=33, %16,3) ile tedavi edilirken bunu meronem/dapson (n=25, %12,3) tedavisi takip etti. Her iki grupta da CRP ve PCT düzeyleri yüksek iken şiddetli sepsis grubunda daha yüksek saptandı. Ne var ki, gruplar arasında istatistiksel olarak anlamlı fark tespit edilemedi. Sepsis hastalarında mort...

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Section: Resultsmentioning

confidence: 99%

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Erenler¹,

Yapar²,

Terzi³

2017

Dicle Tıp Dergisi

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Sepsis in the Emergency Room: Which are the Poor Prognostic Factors?

Dogaru¹,

Teusdea²,

2021

Internal Medicine

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Background. Understanding the underlying cause of mortality in sepsis has broad implications for both trials design and clinical care. A one-size-fits-it-all treatment without considering underlying comorbidities and particularities of a specific patient may have a huge impact on prognosis. Materials and methods. We performed a retrospective, single center observational study of patients admitted in Emergency Department taking into account the suspicion of an infection, serious enough to produce a systemic inflammatory response syndrome. Of this population, we selected the septic patient (Sepsis-3 definition) and studied the impact of comorbidities on prognosis. Results. 125 patients were included. We found that institutionalized patient and respiratory insufficiency were the factors with the biggest impact on prognosis. Close to that, the age was a factor to be taken into account when discussing about prognosis. Other factors as malignancy, diabetes mellitus, cardiac and renal failure were not associated with ominous prognosis, although may have an impact. Two scores (MEDS and NEWS2) and a biomarker were also found to be useful when making a prognosis in such patients. Conclusions. In this retrospective cohort, the institutionalized patient and patients with with respiratory have poor prognosis, while in other diseases, MEDS, NEWS2 and presepsin were reliable prognostic factors.

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Presepsin (sCD14-ST) as a biomarker of sepsis in clinical practice and in emergency department: a mini review

Cited by 2 publications

References 37 publications

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Sepsis in the Emergency Room: Which are the Poor Prognostic Factors?

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