Diagnostic and prognostic value of serum Chitinase 3‐like protein 1 in hepatocellular carcinoma

Abstract

The serum Chitinase 3‐like protein 1 (CHI3L1) protein level can distinguish the stages of liver fibrosis to a great extent. However, the diagnostic and prognostic significance of serum CHI3L1 in hepatocellular carcinoma (HCC) is not clarified. To evaluate the diagnostic and prognostic value of CHI3L1 in HCC, a total of 128 HCC patients treated in the HwaMei Hospital, University of Chinese Academy of Sciences, from December 2018 to April 2020 were collected retrospectively. Matched age and gender subjects, 40 patients with liver cirrhosis, 40 patients with chronic hepatitis, and 40 healthy subjects were enrolled in the control group. The relevant clinical laboratory and examination data and the overall survival time (OS) of the HCC patients were collected. The serum CHI3L1 expression level is related to α‐fetoprotein (AFP), tumor‐node‐metastasis (TNM) stage, maximum tumor diameter, liver cirrhosis, and HCC patient's OS (p < 0.05). The area under the curve (AUC) of CHI3L1 was 0.7875 with the cutoff value of 91.36 ng/ml. Combining the serum CHI3L1 and α‐fetoprotein (AFP) by a binary logistic regression model can increase the diagnostic sensitivity to 97.5%. Multivariate Cox regression analysis indicated that CHI3L1 is an independent prognostic factor in patients with HCC.

Characterization of aging cancer-associated fibroblasts draws implications in prognosis and immunotherapy response in low-grade gliomas

“…As an unfavorable gene involved in ACAFRGs, CHI3L1 was highly expressed in gene cluster A and the high-aging CAF score group ( Figure 3K , Figure 4H ). Consistent with our results, CHI3L1 has been reported to be associated with poor prognosis in hepatocellular carcinoma ( Wang et al, 2022 ). A recent study showed that CHI3L1 was significantly correlated with severe state and adverse prognosis for COVID-19 patients ( Kimura et al, 2021 ).…”

Analytical and Clinical Evaluation of a Chemiluminescent Immunoassay to Detect Serum Chitinase-3-like Protein 1 in HBV-Related Liver Diseases

“…Therefore, it is necessary to further explore CHI3L1 for the diagnosis of liver fibrosis, including large-scale and multicenter studies, multifactor analysis, and the combined application of multiple indicators or methods. CHI3L1 can be used as a biomarker for prognostic assessment and targeted therapy in liver diseases [ 27 , 28 ], which also needs to be validated by using the CLIA. Considering the important clinical value of CHI3L1 in other diseases [ 3 ], the developed CLIA will be a powerful tool to further explore the clinical relevance of CHI3L1.…”

Adipocytes secretome from normal and tumor breast favor breast cancer invasion by metabolic reprogramming

“…CHI3L1 is a non-enzymatic protein of the glycoside hydrolase family 18 that binds chitin. Many studies have shown a strong correlation between CHI3L1 and stages and outcomes of numerous cancers [28][29][30]. CHI3L1 has been reported to promote cancer cells growth, proliferation and metastasis but also angiogenesis, vasculogenic mimicry and tumor associated inflammation [31].…”