Diagnostic and Prognostic Significance of Serum and Tissue Galectin 3 Expression in Patients with Carcinoma of the Bladder

Abstract

Background: Galectins are group of proteins found in the cytoplasm, nucleus, cell surface and extracellular matrix. Galectin 3 (Gal-3) displays pathological expression in a variety of processes such as tumorigenesis. Patients and Method: 70 patients classified into the control group, cystitis group, transitional cell carcinoma group, and squamous cell carcinoma group were enrolled in this study which aimed to detect the serum level and the intensity of tissue expression of Gal-3. Results: Both serum level and tissue expression of Gal-3 were statistically higher in bladder cancer patients compared to the other groups. Gal-3 level expression increased from low to high grade urothelial tumors, with a statistically significant increase of its level and expression between muscle invasive and non-muscle invasive Ta urothelial tumors. Conclusion: The serum Gal-3 level is sensitive and specific for the diagnosis of bladder cancer. The prognostic significance of tissue expression is to be confirmed.

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

“…Serum galectin-3 levels were increased in patients with transitional cell carcinoma compared with squamous cell carcinoma. Patients with high-grade transitional cell carcinoma had a significantly increased serum galectin level compared with those with low-grade tumors, as did those with muscle-invasive transitional cell carcinoma compared with papillary non-invasive tumors ( 158 , 159 ). These results indicated that galectin-3 may be a potential diagnostic biomarker for bladder cancer.…”

The clinical significance of HER2 protein amplification/expression in urinary bladder lesion

“…The recurrence rate after cystectomy approaches 50%, indicating that this treatment alone might not be optimal for some patients [4] . Targeted therapy is a novel treatment strategy in oncology, targeting specific signalling pathways within the malignant cells, and that might enhance the cytotoxic effect but with fewer adverse events [5] .…”

Galectin-3 Level Insera Patients with Bladder Cancer in Babylon Province

“…Besides, Gal-3 could inhibit cell apoptosis, it could also facilitated angiogenesis by its carbohydrate recognitiondomains (CRDs) (24) .These finding is consisting with the earlierstudiesshowed that elevated Gal-3 is dangerous, the depth of invasion, lymph nodemetastasis, distant metastasis and TNM stages in different kind of cancer was associated with Gal-3 level (25,26,27) . However, Gendya H,et al (28) failed to demonstrate this relation and informed no major sta tistical change in serum Gal-3 levels indiverse stage and grade of bladder cancer.…”