Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer

Vassilakopoulos, Theodoros P.; Troupis, Theodoros; Sotiropoulou, Christina; Zacharatos, Panagiotis; Κatsaounou, Paraskevi; Parthenis, Dimitrios G.; Noussia, Olga; Troupis, Georgios; Papiris, Spyros; Kittas, Christos; Roussos, Charis; Zakynthinos, Spyros; Gorgoulis, Vassilis G.

doi:10.1016/s0169-5002(00)00225-7

Cited by 52 publications

(43 citation statements)

References 11 publications

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“…SCC-Ag is also a possible prognostic biomarker. 27) However, because SCC-Ag level was strongly associated with tumor progression, SCC-Ag was not an independent prognostic factor in the current series (data not shown).…”

Section: Discussionmentioning

confidence: 55%

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma

et al. 2003

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High preoperative serum midkine concentration is associated with poor survival in patients with esophageal cancer, even after radical surgery, and thus may have prognostic value. Midkine (MK), a heparin-binding growth factor, is expressed in numerous cancer tissues, and serum MK (S-MK) concentrations are increased in patients with various neoplasms. The aim of this study is to evaluate the clinical significance of S-MK in patients with esophageal squamous cell cancer (SCC). S-MK was measured by enzyme-linked immunosorbent assay in 135 healthy controls, 16 patients with benign esophageal disease, and 93 patients with primary esophageal SCC before surgery. The serum concentrations of carcinoembryonic antigen (CEA), SCC antigen (SCC-Ag), and cytokeratin 19 fragment (CYFRA21-1) were also evaluated. All patients with esophageal SCC underwent radical esophagectomy. Tumor MK expression was assessed by immunohistochemistry in 14 fresh tumor specimens. To determine whether S-MK is of value as a prognostic factor, the authors conducted a survival analysis using Cox's proportional hazards model. S-MK values in patients with esophageal SCC were significantly higher than those in healthy controls (417 ± ± ± ±342 pg/ml vs. 154 ± ± ± ±76 pg/ml, P < < < <0.001). Using 300 pg/ml as the cut-off value (representing the mean + + + +2 standard deviations of the S-MK of healthy controls), 61% of patients with esophageal SCC were classified as positive. MK expression by the tumor was significantly associated with high level of S-MK. High S-MK ( ≥ ≥ ≥ ≥300 pg/ml) was associated with tumor size, immunoreactivity and poor survival. Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival. (Cancer Sci 2003; 94: 628-632)

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Section: Discussionmentioning

confidence: 55%

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma

et al. 2003

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“…[23][24][25][26] However, it appeared that the sensitivities of tumor markers were lower than those reported by others (7.4-24.1 vs. 25.5-66.5%). 21,27 This might be the fact that the majority (67.4%) of lung cancer group were early-staged in our study. Of note, the Youden's index of each tumor marker in our study was very low, suggesting weak diagnostic powers of SCC, CEA, Cyfra21-1 and NSE for lung cancer when used separately.…”

mentioning

confidence: 75%

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Chu¹,

Hou²,

Song³

et al. 2011

Cancer Biology & Therapy

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“…With regard to current biomarkers used in the clinic, this is the expected concentration range, giving us hope that new lung cancer markers should be detectable in serum. Through our method, we successfully identified proteins that are putative or currently used as biomarkers of lung cancer, including CEA (27,28), pro-GRP (29,31), SCC antigen (47,48), tumor M2-PK (49), NCAM (35)(36)(37), chromogranin A (29), and chromogranin B (30). In addition, we identified putative markers previously reported in lung-related proteomics studies such as member C1 of aldo-keto reductase family 1 identified by Huang et al (25) as dihydrodiol dehydrogenase and matrix metallopeptidase 1 found to be overexpressed in lung cancer patients and especially in late stage (18).…”

Section: Discussionmentioning

confidence: 99%

Identification of Five Candidate Lung Cancer Biomarkers by Proteomics Analysis of Conditioned Media of Four Lung Cancer Cell Lines

Planque

Kulasingam

Smith

et al. 2009

Molecular & Cellular Proteomics

133

107

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Detection of lung cancer at an early stage is necessary for successful therapy and improved survival rates. We performed a bottom-up proteomics analysis using a twodimensional LC-MS/MS strategy on the conditioned media of four lung cancer cell lines of different histological backgrounds (non-small cell lung cancer: H23 (adenocarcinoma), H520 (squamous cell carcinoma), and H460 (large cell carcinoma); small cell lung cancer: H1688) to identify secreted or membrane-bound proteins that could be useful as novel lung cancer biomarkers. Proteomics analysis of the four conditioned media allowed identification of 1,830 different proteins (965, 871, 726, and 847 from H1688, H23, H460, and H520, respectively). All proteins were assigned a subcellular localization, and 38% were classified as extracellular or membrane-bound. We successfully identified the internal control proteins (also detected by ELISA), kallikrein-related peptidases 14 and 11, and IGFBP2. We also identified known or putative lung cancer tumor markers such as squamous cell carcinoma antigen, carcinoembryonic antigen, chromogranin A, creatine kinase BB, progastrin-releasing peptide, neural cell adhesion molecule, and tumor M2-PK. To select the most promising candidates for validation, we performed tissue specificity assays, functional classifications, literature searches for association to cancer, and a comparison of our proteome with the proteome of lung-related diseases and serum. Five novel lung cancer candidates, ADAM-17, osteoprotegerin, pentraxin 3, follistatin, and tumor necrosis factor receptor superfamily member 1A were preliminarily validated in the serum of patients with lung cancer and healthy controls. Our results demonstrate the utility of this cell culture proteomics approach to identify secreted and shed proteins that are potentially useful as serologi-

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Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer

Cited by 52 publications

References 11 publications

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Identification of Five Candidate Lung Cancer Biomarkers by Proteomics Analysis of Conditioned Media of Four Lung Cancer Cell Lines

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