Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma

Abstract

OBJECTIVE:A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma. METHODS: LINC00173 expression was measured in 163 paired cancerous and noncancerous specimen samples by real-time polymerase chain reaction. The correlations between LINC00173 expression with clinicopathological characteristics and prognosis were analyzed by chi-square test, log-rank test, and multivariate survival analysis. Receiver-operating characteristic curves were used for the assessment of the diagnostic value of LINC00173 for melanoma patients. RESULTS: The expression level of LINC00173 in melanoma specimens was distinctly higher than that in adjacent non-neoplasm specimens (p<0.01). Besides, LINC00173 was expressed more frequently in patients with advanced melanoma than in patients with early melanoma. Multivariate assays confirmed that LINC00173 expression level was an independent prognostic predictor of melanoma patients (p<0.05). CONCLUSION: Our data indicated that LINC00173 expression could serve as an unfavorable prognostic biomarker for melanoma patients.

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

“…However, studies have not fully revealed the functions of LINC00173 in other cancers. On the other hand, five reports predict that LINC00173 may be involved in the development of diseases through bioinformatics analysis [ 19 , 73 , 74 , 75 , 76 ], Thus, it is necessary to study the biological function and molecular mechanism of LINC00173 in human diseases by molecular experiments.…”

Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells

“…ncRNAs play vital regulatory roles in developing and increasing tumorigenesis by interacting with different signaling pathways, and contain more than 80 % of the genomic content. The lack of interaction of ncRNAs with signaling networks may result in some diseases, such as cancer [ [48] , [49] , [50] , [51] ]. In addition, ncRNAs are able to induce [ 8 ] or inhibit tumorigenesis through the Hippo pathway in Refs.…”

Regulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review

“…Shi et al investigated the role of lncRNA H19 in melanoma and found H19 was highly expressed in melanoma tissues compared to normal adjacent skin tissues and H19 expression levels were significantly higher in patients with metastatic melanoma compared to melanoma patients without distant metastasis ( p < 0.01) [ 24 ]. Similarly, long intergenic ncRNA 173 (LINC00173) expression was significantly higher in melanoma tissues compared to adjacent non-neoplastic tissues ( p < 0.01) and was expressed more frequently in melanoma patients with distant metastasis compared to patients at an earlier stage of melanoma [ 41 ]. Another study found that lncRNA LINC02249 expression was significantly elevated in cutaneous melanoma samples and a high expression of LINC02249 was associated with shorter overall survival in melanoma patients [ 42 ].…”