Diagnostic and Prognostic Implications of Cardiac Markers for Hepatocellular Carcinoma

Ghanta, Mohan Krishna; Khan, Afzal; Bhaskar, L. V. K. S.

doi:10.1615/critrevoncog.2020036305

Cited by 2 publications

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“…Protein denaturation occurs through a mechanism that is unexpected and involves changes to hydrophobic, disulfide, and electrostatic hydrogen bonds. [ 14 ] In inflammatory diseases such rheumatoid arthritis, cancer, [ 15 ] neurodegeneration [ 16 - 17 ] and diabetes, [ 18 ] denaturation of proteins results in the creation of autoantigens. Therefore, it is possible to reduce inflammatory activity by inhibiting protein denaturation.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant effects of hydro-alcoholic extract of Dicliptera cuneata Nees aerial parts

Suresh

2023

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Dicliptera cuneata Nees is a traditional medicinal plant but its extract or phytochemicals are less known. Therefore, it is of interest to investigate the anti-inflammatory and antioxidant effects of aerial part hydroalcoholic extract of Dicliptera cuneata Nees. Hence, we used protein denaturation assay, FRAP assay, Nitric oxide and peroxide scavenging assays methods following standard developed techniques. The hydro-alcoholic extract exhibited dose-dependent effectiveness in all the assays and showed maximum efficacy in the assays at higher doses selected. Data shows that hydroalcholic extract of Dicliptera cuneata Nees showed anti-inflammatory and antioxidant properties in in vitro settings. It should be noted that more data is needed to further develop the extract into suitable formulations.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant effects of hydro-alcoholic extract of Dicliptera cuneata Nees aerial parts

Suresh

2023

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“…Risk factors for hypertension are diabetes (15%-20%), lipid disorders (elevated lowdensity lipoprotein-cholesterol (LDL-C) and triglycerides (30%), overweight-obesity (40%), hyperuricemia (25%) and metabolic syndrome (40%), as well as unhealthy lifestyle habits (eg, smoking, high alcohol intake, sedentary lifestyle). More than 50% of hypertensive patients have additional cardiovascular risk factors (Lopez, Mathers, Ezzati, Jamison, & Murray, 2006;Tunstall-Pedoel, Chen, & Kramarz, 2004;Ghanta, Khan, & Bhaskar, 2021).…”

Section: Introductionmentioning

confidence: 99%

comparative study on efficacy of chlorthalidone and azilsartan in confirmed cases of hypertension associated with ace gene polymorphism

Chaithanya¹,

Gorantla²,

Addepalli³

et al. 2022

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The angiotensin-converting enzyme (ACE) gene consists of 26 exons, it is located on chromosome 17 and its polymorphism is a major contributing factor to hypertension. The aim is to compare the efficacy of Chlorthalidone and Azilsartan in newly diagnosed hypertension patients in association with ACE gene polymorphism. The study was conducted in the department of pharmacology, Rama medical college, Kanpur. After doing genetic test and basic investigation, 90 newly diagnosed patients with hypertension associated with ACE gene polymorphism were recruited, followed by grouping into two A&B. Group-A(n=45) patients were given Azilsartan 45mg/day and group-B(n=45) patients were given Chlorthalidone 25mg/day for 3 months. Systolic and diastolic blood pressure (SBP& DBP) was measured before and after 3 months of treatment in both groups and they were compared. Three genotypes were found in ACE gene polymorphism-associated hypertension cases such as I/I, I/D and D/D, the severity of hypertension is more in the D/D genotype followed by I/D and I/I genotypes. All three genotypes of both group-A & B had shown a significant mean reduction in SBP& DBP after 3 months of treatment (p<0.05) but the mean reduction was high in the I/I genotype followed by the I/D and then D/D genotype.

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Diagnostic and Prognostic Implications of Cardiac Markers for Hepatocellular Carcinoma

Cited by 2 publications

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Anti-inflammatory and antioxidant effects of hydro-alcoholic extract of Dicliptera cuneata Nees aerial parts

Anti-inflammatory and antioxidant effects of hydro-alcoholic extract of Dicliptera cuneata Nees aerial parts

comparative study on efficacy of chlorthalidone and azilsartan in confirmed cases of hypertension associated with ace gene polymorphism

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