Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders

Gibson, David; Banha, João; Penque, Deborah; Costa, Luciana; Conrads, Thomas P.; Cahill, Dolores J.; O’Brien, John; Rooney, Madeleine

doi:10.1016/j.jprot.2009.11.013

Cited by 27 publications

(24 citation statements)

References 88 publications

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“…Proteomic techniques based on mass spectrometry approaches are nowadays being widely applied in autoimmune diseases for the identification of biomarkers, which could serve for diagnostic, prognostic, or even therapeutic purposes. 4 Although biomarker profiling of aqueous humor (AH) has not frequently been performed, the applicability of surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-ToF MS) for this purpose has been demonstrated. [5][6][7][8] In this report, we provide data on proteomic analysis of paired AH and serum samples of pediatric uveitis patients, including JIA, silent chronic noninfectious anterior uveitis (AU), other uveitic entities, and noninflammatory pediatric controls with cataract and/or glaucoma.…”

mentioning

confidence: 99%

Intraocular Biomarker Identification in Uveitis Associated With Juvenile Idiopathic Arthritis

Ayuso

Boer

Byers

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the presence of biomarkers in aqueous humor (AH) from patients with uveitis associated with juvenile idiopathic arthritis (JIA).METHODS. AH (n ¼ 73) and serum (n ¼ 105) samples from 116 children were analyzed using surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-ToF MS). The samples were divided into the following groups: JIA, silent chronic anterior uveitis (AU), other uveitis entities, and noninflammatory controls. Statistical biomarker identification was performed using the SELDI-ToF Biomarker Analysis Cluster Wizard followed by multivariate statistical analysis. Biochemical identification of biomarkers was performed by polyacrylamide gel protein separation, followed by liquid chromatography tandem mass spectrometry. ELISA was performed in a number of AH samples representing all four study groups.RESULTS. In the JIA group, one AH protein peak at mass/charge (m/z) 13,762 had qualitative and quantitative differences in expression compared with the other uveitis entities and the controls, but not to the group of silent chronic AU. Its quantitative expression in AH of patients with JIA and other silent chronic AU was positively associated with uveitis activity. The protein at m/z 13,762 in AH was identified as transthyretin (TTR). The TTR concentration in AH differed significantly between the study groups (P ¼ 0.006) with considerably higher TTR concentrations in JIA and silent chronic AU samples positive for m/z 13,762 than those of the other uveitis and control groups.CONCLUSIONS. TTR is a potential intraocular biomarker of JIA-associated uveitis. Its role in the pathogenesis of silent chronic AU with and without arthritis needs further investigation.

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mentioning

confidence: 99%

Intraocular Biomarker Identification in Uveitis Associated With Juvenile Idiopathic Arthritis

Ayuso

Boer

Byers

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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show abstract

“…4 Etiyolojide çevresel faktörlerin yanı sıra, kişiye özgü antijenlerde gen regülasyon bozukluğu suç-lanmaktadır. 5 Betterle ve ark. tarafından OPS dört gruba ayrılmıştır.…”

Section: Down Sendromu Hashimoto Tiroiditi İnsülin Bağımlı Tip 1 DIunclassified

Down's Syndrome, Hashimoto's Thyroiditis, Insulin-Dependent Type 1 Diabetes Mellitus and Autoimmune Gastroenteropathy: A Rare Combination: Case Report

Sivritepe¹,

Basat²,

Olcum³

et al. 2016

Turkiye Klinikleri J Endocrin

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“…OPS'de kişisel ve çevresel faktörler rol almaktadır 2 . OPS'nin dört tipi vardır; OPS tip 3 kendi içinde 3A, 3B, 3C ve 3D olmak üzere dört gruba ayrılır.…”

Section: Introductionunclassified

A rare case of autoimmune polyglandular syndromes type 3A-3B presented with latent autoimmune diabetes in adults (LADA)

Oral¹,

Yakar²,

Uzunlulu³

et al. 2017

MMJ

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Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders

Cited by 27 publications

References 88 publications

Intraocular Biomarker Identification in Uveitis Associated With Juvenile Idiopathic Arthritis

Intraocular Biomarker Identification in Uveitis Associated With Juvenile Idiopathic Arthritis

Down's Syndrome, Hashimoto's Thyroiditis, Insulin-Dependent Type 1 Diabetes Mellitus and Autoimmune Gastroenteropathy: A Rare Combination: Case Report

A rare case of autoimmune polyglandular syndromes type 3A-3B presented with latent autoimmune diabetes in adults (LADA)

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