Diagnostic accuracy of the BJI InoPlex™ (Diaxonhit) immunoassay on blood samples for periprosthetic joint infection in complex microbiological situations. Preliminary results of 24 cases in a French Reference Center for Complex Bone and Joint Infection (CRIOAC)

Dartus, Julien; Martinot, Pierre; Leclerc, J.; Senneville, Éric; Wallet, Frédéric; Putman, Sophie; Migaud, Henri; Loïez, Caroline

doi:10.1016/j.otsr.2021.102909

Cited by 4 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…included eleven hip and thirteen knee arthroplasty cases. The sensitivity for diagnosing a chronic PJI based on the 2018 ICM criteria was 50% and the specificity was 56% ( Dartus et al., 2021 ) ( Figure 2 , 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Dartus et al included eleven hip and thirteen knee arthroplasty cases. The sensitivity for diagnosing a chronic PJI based on the 2018 ICM criteria was 50% and the specificity was 56% (Dartus et al, 2021) (Figure 2, 3). D-lactate was studied in the largest cohort of patients (148 and 224) by Karbysheva et al and Yermak et al who used different PJI criteria.…”

Section: Othersmentioning

confidence: 99%

See 1 more Smart Citation

Novel diagnostic markers for periprosthetic joint infection: a systematic review

Schindler

Walter

Maderbacher

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundIdentifying novel biomarkers that are both specific and sensitive to periprosthetic joint infection (PJI) has the potential to improve diagnostic accuracy and ultimately enhance patient outcomes. Therefore, the aim of this systematic review is to identify and evaluate the effectiveness of novel biomarkers for the diagnosis of PJI.MethodsWe searched the MEDLINE, EMBASE, PubMed, and Cochrane Library databases from January 1, 2018, to September 30, 2022, using the search terms “periprosthetic joint infection,” “prosthetic joint infection,” or “periprosthetic infection” as the diagnosis of interest and the target index, combined with the term “marker.” We excluded articles that mentioned established biomarkers such as CRP, ESR, Interleukin 6, Alpha defensin, PCT (procalcitonin), and LC (leucocyte cell count). We used the MSIS, ICM, or EBJS criteria for PJI as the reference standard during quality assessment.ResultsWe collected 19 studies that analyzed fourteen different novel biomarkers. Proteins were the most commonly analyzed biomarkers (nine studies), followed by molecules (three studies), exosomes (two studies), DNA (two studies), interleukins (one study), and lysosomes (one study). Calprotectin was a frequently analyzed and promising marker. In the scenario where the threshold was set at ≥50-mg/mL, the calprotectin point-of-care (POC) performance showed a high sensitivity of 98.1% and a specificity of 95.7%.ConclusionNone of the analyzed biomarkers demonstrated outstanding performance compared to the established parameters used for standardized treatment based on established PJI definitions. Further studies are needed to determine the benefit and usefulness of implementing new biomarkers in diagnostic PJI settings.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

Novel diagnostic markers for periprosthetic joint infection: a systematic review

Schindler

Walter

Maderbacher

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

Investigation of the pathogen-specific antibody response in periprosthetic joint infection

Janz,

Rakow,

Schröder

et al. 2024

Infection

View full text Add to dashboard Cite

Purpose Periprosthetic joint infections (PJIs) are a very demanding complication of arthroplasty. Diagnosis of PJI and pathogen identification pose considerable challenges in clinical practice. We hypothesized that the pathogen-specific immune response to PJI reflects the infection process, provides clinically relevant information on disease course, and has the potential to further optimize antimicrobial therapy. Methods We conducted a prospective matched cohort pilot study with 13 patients undergoing two-stage septic revision arthroplasty (PJI patients) between 06/2020 and 06/2021, as well as 11 control patients undergoing one-stage aseptic revision arthroplasty (Non-PJI patients). Pre-, intra- and postoperative serum samples were collected at standardized time points. We developed a custom Luminex®-based quantitative bead-based suspension array (Infection Array; IA), and used it for simultaneous measurement of antibody specificities against 32 pathogens commonly associated with PJI in 267 serum samples. Results The IA was able to trace the dynamics of the pathogen-specific humoral immune response in all patients against PJI-related pathogens, prominently coagulase-negative staphylococci and streptococci. Pathogen-specific serum antibody titers declined in 62% of PJI patients over the course of treatment, while no changes in antibody titers were observed in 82% of Non-PJI patients during this study. Our serological data strongly suggested that antibody signatures reflect an immune response to microbial invasion. Conclusion Our results provide insights into the pathophysiology of PJI and information on the individual disease courses. The IA is therefore a promising and novel serological tool of high resolution for monitoring the immunoproteomic footprints of infectious pathogens in the course of PJI.

show abstract

La reprise chirurgicale pour hématome postopératoire sur prothèse de hanche ou de genou nécessite-t-elle la réalisation systématique de prélèvements en fonction du délai de survenue ? Analyse rétrospective au recul minimal de 2 ans de 78 hématomes évacués chirurgicalement

Charlès

Martinot

Dartus

et al. 2023

Revue de Chirurgie Orthopédique et Traumatologique

View full text Add to dashboard Cite

Diagnostic accuracy of the BJI InoPlex™ (Diaxonhit) immunoassay on blood samples for periprosthetic joint infection in complex microbiological situations. Preliminary results of 24 cases in a French Reference Center for Complex Bone and Joint Infection (CRIOAC)

Cited by 4 publications

References 23 publications

Novel diagnostic markers for periprosthetic joint infection: a systematic review

Novel diagnostic markers for periprosthetic joint infection: a systematic review

Investigation of the pathogen-specific antibody response in periprosthetic joint infection

La reprise chirurgicale pour hématome postopératoire sur prothèse de hanche ou de genou nécessite-t-elle la réalisation systématique de prélèvements en fonction du délai de survenue ? Analyse rétrospective au recul minimal de 2 ans de 78 hématomes évacués chirurgicalement

Contact Info

Product

Resources

About