Diagnostic Accuracy of rhTSH Test with Neck Ultrasonography in Differentiated Thyroid Cancer Follow-up

Fumarola, Angela; D’Alessandri, M.; Dicorato, P.; Grani, Giorgio; Maiuolo, A.; Ruggieri, Martino; Calvanese, A.

doi:10.1055/s-0029-1241204

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Therefore, considering the consequences of a prolonged hypothyroid state on QoL, the use of recombinant human TSH is recommended for DTC patients during follow-up and for patients who do not achieve satisfactory levels of endogenous TSH with thyroid hormone withdrawal or have contraindications for hypothyroidism because of other pathologies. Some studies confirm, in fact, that rhTSH is not only effective in obtaining high TSH levels 26,27 but also guarantees superior QoL and equivalent societal costs. 28,29 In thyroidectomized patients, for whom a faster rise of thyrotrophin to !…”

Section: Discussionmentioning

confidence: 90%

An easy schedule for postsurgical radioiodine administration in newly diagnosed differentiated thyroid carcinoma patients

Lupoli

Poggiano

Panico

et al. 2012

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 90%

An easy schedule for postsurgical radioiodine administration in newly diagnosed differentiated thyroid carcinoma patients

Lupoli

Poggiano

Panico

et al. 2012

Clinical Endocrinology

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Quercetin alleviates hyperthyroidism‐induced liver damage via Nrf2 Signaling pathway

Zhao

et al. 2020

BioFactors

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Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Quercetin was injected at a series doses (5, 50, and 100 mg/kg) to LT4‐induced hypothyroidism rats once a day for 14 days. The body weight and food intake were measured once a week. The levels of thyroid hormones, liver function, oxidative stress markers, and antioxidant markers were measured using commercial enzyme‐linked immunosorbent assay kits. Hematoxylin–eosin staining was used to observe the thyroid tissue histological changes. The levels of nuclear and total nuclear factor erythroid 2‐related factor 2 (Nrf2) were determined by western blot. The liver oxidative stress markers in LT4‐induced hyperthyroidism Nrf2 knockout rats were determined to evaluate the role of Nrf2 on quercetin induced protective effects. LT4 administration increased the levels of serum triiodothyronine and thyroxine, activity of oxidative stress markers with a parallel decrease in antioxidant markers and Nrf2. However, the simultaneous administration of quercetin, reversed all these effects indicating its potential in the regulation of hyperthyroidism. Furthermore, the loss function of Nrf2 diminished these effects resulting from the quercetin application, indicating the inhibitory effects caused by the quercetin may be involved in Nrf2 signaling pathway. These results indicate that quercetin could be used to protect against experimental hyperthyroidism‐induced liver damage via Nrf2 signaling pathway.

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Therapeutic Effects of Blue Honeysuckle on Lesions of Hyperthyroidism in Rats

et al. 2016

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Hyperthyroidism is a hypermetabolic syndrome characterized by an overproduction of thyroid hormones, which enhances the hormone-induced oxidative stress responsible for some complications in the liver, heart and muscle. Blue honeysuckle (BH) is an edible berry, rich in polyphenols, especially flavonoids or anthocyanins, known as strong antioxidants. The chemo-protective activities of the berry have been connected to the improvement of symptoms in cancer, diabetes mellitus, tumor or cardiovascular diseases. Therefore, the therapeutic effects of BH were examined in hyperthyroidism rat model. The hyperthyroidism was induced by injection with levothyroxine (LT4), and the model was treated with distilled water (LT4 control), propylthiouracil (PTU) or BH at 3 dosages of 500, 250 and 125[Formula: see text]mg/kg. The treatment was performed once a day for 15 days. Compared to LT4 control, the oral administration of BH dose-dependently ameliorated the hyperthyroidism, reducing thyroid hormones and increasing thyroid stimulating hormones. These effects were accompanied by improvement of body weight loss and atrophy in the thyroid gland, liver and epididymal fat pads. BH treatments also reduced the levels of hepatic enzymes (AST and ALT), which suggests BH exerts protective effects on hepatocytes. BH might also be involved in the augmentation of the anti-oxidant activities, supported by increased endogenous antioxidant (glutathione). In addition, the histopathological analyses revealed the beneficial effects of BH on the atrophic changes and cellular injuries in the thyroid gland, liver and epididymal fat pads. The therapeutic potentials of BH were either similar or more effective than PTU. These results provide valuable information that will guide more detailed studies to use the BH as a complementary and alternative medicine.

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Diagnostic Accuracy of rhTSH Test with Neck Ultrasonography in Differentiated Thyroid Cancer Follow-up

Cited by 3 publications

References 5 publications

An easy schedule for postsurgical radioiodine administration in newly diagnosed differentiated thyroid carcinoma patients

An easy schedule for postsurgical radioiodine administration in newly diagnosed differentiated thyroid carcinoma patients

Quercetin alleviates hyperthyroidism‐induced liver damage via Nrf2 Signaling pathway

Therapeutic Effects of Blue Honeysuckle on Lesions of Hyperthyroidism in Rats

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