Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Narrow Band Imaging for Small Colorectal Polyps: A Feasibility Study

Abstract

pCLE demonstrated higher sensitivity in predicting histology of small polyps compared with NBI, whereas NBI had higher specificity. When used in combination, the accuracy of pCLE and NBI was extremely high, approaching the accuracy of histopathology. Together, they may reduce the need for histological examination. However, further studies are warranted to evaluate the role of these techniques, especially in the population-based colon cancer screening.

Imaging the Leaky Gut

“…6 Instead, people tend to eat in dietary patterns, ranging from the healthy fat and plant-rich Mediterranean diet to the "meat-sweet" diet of developed countries heavy in processed foods, refined sugars, and red meat. 7 The current study, 3 and recent publications demonstrating reduced HCC risk in adherents to a Mediterranean food pattern or a diet low in red meat, [8][9][10] support this perspective. Yang et al 3 present a meta-analysis including 10 cohort and 9 case-control studies conducted in Asia, Europe, and the United States that evaluated the association of 2 whole foods-fruits and vegetables-with HCC risk.…”

“…Previously explored applications of these new CLE technologies include detection and classification of neoplasia in the colonic polyps, 6,7 inflammatory bowel disease, 8,9 Barrett's esophagus, 1 and the stomach. 10 Molecular imaging with tagged monoclonal antibody has enabled imaging of antiendothelial growth factor receptor monoclonal antibody binding to targets and predication of response to endothelial growth factor receptor chemotherapy.…”

Status of confocal laser endomicroscopy in gastrointestinal disease

“…Probe-based CLE demonstrated higher sensitivity in predicting histology of small polyps compared with NBI, whereas NBI had higher specificity. 61 Further development of CLE may obviate the need to sample all visualised polyps at colonoscopy. Residual neoplasia after EMR of colorectal lesions is common and CLE can significantly increase the sensitivity for detecting residual neoplasia after endoscopic mucosal resection compared with endoscopy alone.…”

Precancerous Lesions in Gastrointestinal Tract

“…9 Examination of endo-microscopy performed using confocal laser endomicroscope Pentax or with Cellvizio probe-based optical mini microscope. [22][23][24][25] MiRNA expression can differentiate normal to pathological lesions, and among precancerous lesions, it may be able to classify different subtypes.…”