Diagnostic Accuracy of Insulin-like Growth Factor–Binding Protein-1/alpha-Fetoprotein (AmnioQuick Duo) in Ruptured Fetal Membranes

Abdelazim, Ibrahim A.; Shikanova, Svetlana; Karimova, Bakyt; Sarsembayev, Mukhit; Mukhambetalyeva, Gulmira; Bekzhanova, Mariya

doi:10.1007/s42399-020-00600-w

Cited by 4 publications

(4 citation statements)

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“…The gestational age calculated from the last menstrual period and confirmed by ultrasound done ≤20 weeks'. [ 9 10 ]…”

Section: Discussionmentioning

confidence: 99%

Abdelazim equation

Abdelazim

2021

Journal of Family Medicine and Primary Care

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Measurement of 24-h urine protein (UP) is the standard method for detection of proteinuria in preeclampsia (PE). A 24-h urine sampling is time-consuming, inconvenient, and delays the diagnosis of PE. A 29-year-old woman, previous cesarean section (CS), pregnant 37 weeks' +2 days , mild PE, and another 31-year-old woman, primipara, pregnant 34 weeks' +4 days , severe PE, were admitted for control of blood pressure and termination of pregnancy. Studied women were subjected to fetal well-being assessment, routine antenatal, and laboratory investigations to exclude chronic renal diseases, and for 24-h urine sampling. A spot mid-stream urine sample was obtained shortly before the 24-h urine sampling to measure the protein/creatinine (P/C) ratio. The first studied woman had normal serum creatinine and blood urea, 688 mg protein/24-h urine, 86 mg/dL spot UP, 178 mg/dL spot urine creatinine, and 0.48 P/C ratio. The second studied woman had also normal serum creatinine and blood urea, 1199 mg protein/24-h urine, 147 mg/dL spot UP, 133 mg/dL spot urine creatinine, and 1.11 spot P/C ratio. The spot urine sample was suggested by the National Kidney Foundation to detect and monitor proteinuria in adults. Moreover, the 24-h UP can be calculated from the following equation: 24-h UP in g = P/C ratio × 0.81 + 0.3 (Abdelazim equation) without 24-h urine sampling. This report suggests the use of Abdelazim equation (24-h UP in g = P/C ratio × 0.81 + 0.3) for detection of 24-h UP from spot urine sample in PE without 24-h urine sampling.

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“…The gestational age calculated from the last menstrual period and confirmed by ultrasound done ≤20 weeks'. [ 9 10 ]…”

Section: Discussionmentioning

confidence: 99%

Abdelazim equation

Abdelazim

2021

Journal of Family Medicine and Primary Care

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“…The diagnosis of PPROM was based on patient's history of water gush, confirmed by visualization of amniotic fluid (AF) pooling from the cervical canal during sterile speculum examination, positive nitrazine, AmnioQuick Duo test [1,15], and amniotic fluid index (AFI) ≤ 5 cm using trans-abdominal ultrasound (TAS) [16].…”

Section: Methodsmentioning

confidence: 99%

“…The preterm premature rupture of fetal membranes rupture (PPROM) is one of the common problems in obstetrics [1]. It occurs in approximately 3-5% of all pregnancies [2][3][4], and accounts for 30-40% of preterm deliveries (PTDs) [5].…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-6 bedside test in detecting chorioamnionitis in women with preterm premature rupture of fetal membranes

2022

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Objectives: About 30-80% of preterm deliveries following preterm premature rupture of fetal membranes (PPROM) are complicated by histological chorioamnionitis. To evaluate the accuracy of Interleukin-6 (IL-6) bedside test in detecting chorioamnionitis in women with PPROM. Material and methods: One hundred and ten (110) pregnant women with PPROM > 24 and < 34 weeks' gestation, admitted for conservative management were included in this study. Participants were examined on admission using sterile speculum examination for assessment of IL-6 in the cervico-vaginal secretions using the IL-6 bedside test. The IL-6 bedside test was repeated for all participants once termination of pregnancy (TOP) decided. After TOP, placenta, umbilical cord, and fetal membranes samples were examined for histologic detection of chorioamnionitis (gold standard). The histological results were compared with IL-6 bedside test results to evaluate the accuracy of IL-6 bedside test in detecting chorioamnionitis in women with PPROM. Results:The IL-6 bedside test had 98.6% sensitivity, 94.7% specificity, 97.3% positive predictive value (PPV), 97.3% negative predictive value (NPV) and 97.3% overall accuracy in detecting chorioamnionitis. The sensitivity, specificity, NPV and overall accuracy of IL-6 bedside test (98.6%, 94.7%, 97.3%, and 97.3%; respectively) were significantly higher than the clinical and laboratory parameters of chorioamnionitis (65.3%, 57.9%, 46.8%, and 62.7%; respectively) (p = 0.04, 0.02, 0.001 and 0.03; respectively). Conclusions:The IL-6 bedside test is an accurate, non-invasive bedside test with 98.6% sensitivity, 94.7% specificity, 97.3% PPV, 97.3% NPV, and 97.3% overall accuracy in detecting chorioamnionitis. The IL-6 bedside test had significantly higher sensitivity, specificity, NPV, and overall accuracy than the clinical and laboratory parameters of chorioamnionitis.

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