Diagnostic accuracy of fine needle aspiration cytology in thyroid swellings with histopathological correlation

Patil, Mahadeo R.; Patil, Sandhyarani M.

doi:10.18203/2349-2902.isj20181139

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…[1] In India, the prevalence of a palpable thyroid nodule is approximately 12.2%, according to a recent study. [2] Although thyroid cancer is quite rare with an incidence of 8.7 per 100,000 people per year, this seems to be increasing over the years.…”

Section: Introductionmentioning

confidence: 99%

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Khatri

Choudhury

Thomas

2017

J Cytol

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Context:Thyroid nodules represent a common problem, with an estimated prevalence of 4–7%. Although fine needle aspiration cytology (FNAC) has been accepted as a first line diagnostic test, the rate of false negative reports of malignancy is still high. Nuclear morphometry is the measurement of nuclear parameters by image analysis. Image analysis can merge the advantages of morphologic interpretation with those of quantitative data.Aims:To evaluate the nuclear morphometric parameters in fine needle aspirates of thyroid lesions and to study its role in differentiating benign from malignant thyroid lesions.Material and Methods:The study included 19 benign and 16 malignant thyroid lesions. Image analysis was performed on Giemsa-stained FNAC slides by Nikon NIS-Elements Advanced Research software (Version 4.00). Nuclear morphometric parameters analyzed included nuclear size, shape, texture, and density parameters.Statistical Analysis:Normally distributed continuous variables were compared using the unpaired t-test for two groups and analysis of variance was used for three or more groups. Tukey or Tamhane's T2 multiple comparison test was used to assess the differences between the individual groups. Categorical variables were analyzed using the chi square test.Results and Conclusion:Five out of the six nuclear size parameters as well as all the texture and density parameters studied were significant in distinguishing between benign and malignant thyroid lesions (P < 0.05). Cut-off values were derived to differentiate between benign and malignant cases.

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Section: Introductionmentioning

confidence: 99%

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Khatri

Choudhury

Thomas

2017

J Cytol

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“…The worldwide prevalence of palpable thyroid nodule is estimated to range between 4-7% in the adult population; while it is reported to be approximately 12.2% in India. 1,2 An analysis of the surveillance, epidemiology and end results database from the United States showed tripling of thyroid cancer incidence over 35 years beginning in the year 1975.…”

Section: Original Articlementioning

confidence: 99%

“…Numerous and diverse pathologic lesions in the eyelids are due to their unique anatomical features as the whole skin structures with its appendages, skeletal muscle, modified glands, and conjunctival mucous membrane are represented in the eyelid. 1,2 Eyelid lesions can be divided into congenital, inflammatory, nonneoplastic masses, and neoplasms (benign or malignant). Neoplastic lesions can be further classified…”

Section: Introductionmentioning

confidence: 99%

Study of nuclear morphometry in the cytologic evaluation of thyroid neoplasms

Thomas,

Chhadi,

Chhadi

2023

J Pathol Nep

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Background: Nuclear morphometry is purported to allow better differentiation between various thyroid lesions beyond what is offered by conventional cytology. The present study was conducted to evaluate the nuclear morphometric parameters in fine needle aspirates of thyroid neoplasms and to study their role in differentiating benign and malignant thyroid neoplasms. Materials and Methods: Nuclear morphometric parameters of all the patients presenting with thyroid swelling and undergoing fine needle aspiration cytology (FNAC) and belonging to Category III, IV, V, and VI of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) were studied. Results: Out of a total of 60 cases, a maximum was noted from category IV which is follicular neoplasm or suspicious for follicular neoplasm. The sensitivity of FNAC for the diagnosis of thyroid lesions in the present study was observed at 87.71%. The nuclear morphometry parameters – short axis diameter, long axis diameter, nuclear area, and perimeter showed significant differences between benign and malignant lesions (p-value <0.001). The mentioned nuclear morphometric parameters were observed to be the highest in anaplastic carcinoma followed by papillary carcinoma and medullary carcinoma, and lowest in follicular neoplasms. A significant difference was observed in the nuclear parameters of follicular adenoma and follicular carcinoma. Conclusions: Nuclear morphometry can help in distinguishing between benign and malignant thyroid lesions, particularly in the diagnosis of indeterminate smears where there is a disparity in diagnosis on conventional cytology, especially in differentiating follicular neoplasms.

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“…The anatomopathological evaluation of thyroid gland investigations typically begins with a cytological examination, which serves as a preoperative elective method for establishing a definitive diagnosis of benignity or malignancy (6).…”

Section: Introductionmentioning

confidence: 99%

Morphometric study in thyroid tumors

Mohorea,

Socea,

Carâp

et al. 2023

Exp Ther Med

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Various morphonuclear studies using digital image analysis have been taken into account in order to establish the malignancy of thyroid lesions based on their size and on the chromatographic characteristics of tumor cell nuclei. Nuclear morphometry involves the measurement of nuclear parameters to obtain diagnostically important information in an objective and reproducible manner. The aim of the present study was to evaluate the detailed morphometric analysis of histopathological preparations with lesions of the thyroid gland and to investigate its role in differentiating between benign and malignant thyroid lesions. The present study included 10 benign and 26 malignant thyroid cases with different selected thyroid lesions. Using a microscope connected to a computerized video system, nuclear morphometric parameters including the nuclear area, perimeter, average intensity, red average, width and roundness, were measured and analyzed. The main parameters used in the statistical calculation were significant in distinguishing between benign and malignant thyroid lesions. The association of morphometry in cytological smears for suspected malignant follicular lesions led to increased accuracy in establishing a suspicious malignant diagnosis for follicular lesions. Nuclear morphometry provides an unbiased point of view that increases diagnosis accuracy. Computerized morphometry can positively influence diagnostic accuracy, allowing for a better correlation with clinical and imaging data.

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Diagnostic accuracy of fine needle aspiration cytology in thyroid swellings with histopathological correlation

Cited by 3 publications

References 3 publications

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Study of nuclear morphometry in the cytologic evaluation of thyroid neoplasms

Morphometric study in thyroid tumors

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