Diagnostic accuracy and discriminative power of biparametric versus multiparametric MRI in predicting muscle-invasive bladder cancer

Elshetry, Al Shaimaa Fathi; El-fawakry, Rabab Mahmoud; Hamed, Enas Mahmoud; Metwally, Maha Ibrahim; Zaid, Nesma Adel

doi:10.1016/j.ejrad.2022.110282

Cited by 6 publications

(8 citation statements)

References 39 publications

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Section: Discussionmentioning

confidence: 95%

“…In a study with 54 patients with BCa , bpMRI and mpMRI had comparable diagnostic accuracy in predicting MIBC, with no statistically significant differences in AUCs [reader 1: 0.985 (0.912–0.998) vs. 0.968 (0.884–0.996), p = 0.154; reader 2: 0.942 (0.846–0.986) and 0.936 (0.839–0.983), p = 0.345; and reader 3: 0.945 (0.848–0.986) and 0.935 (0.838–0.983), p = 0.338, in bpMRI vs. mpMRI, respectively] 13 . Moreover, the inter-reader agreement of VI-RADS was good for both bpMRI (k range, 0.814–0.86) and mpMRI (k range, 0.787–0.859) 13 . Furthermore, in a meta-analysis of 10 studies on mpMRI and 7 studies on mpMRI/bpMRI comprising ≥ VI-RADS 3 as the cut-off, the sensitivities of bpMRI and mpMRI were not significantly different (p = 0.15), yet bpMRI was more specific [0.90 (0.81–0.95) vs. 0.86 (0.77–0.91), p = 0.02, in bpMRI vs. mpMRI] 36 .…”

Section: Discussionmentioning

confidence: 95%

“…However, to the best of our knowledge, only a few studies have compared DWI and DCE sequences for VI-RADS assessment, and most had a small sample size [11][12][13][14][15] . Furthermore, the authors of previous studies only compared the performance of DWI and DCE in the same patients who underwent mpMRI, not contrast-free bpMRI.…”

Section: Discussionmentioning

confidence: 99%

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Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Noh

Shim

Kang

et al. 2022

Sci Rep

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This study aimed to compare the diagnostic validity of biparametric magnetic resonance imaging (bpMRI) with that of multiparametric MRI (mpMRI) based on the Vesicle Imaging-Reporting and Data System (VI-RADS) in predicting muscle invasion by bladder cancer (BCa). We retrospectively examined 357 patients with an initial diagnosis of BCa who underwent preoperative MRI; 257 and 100 patients underwent mpMRI and bpMRI, respectively. Two urogenital radiologists evaluated all bpMRI and mpMRI scans using VI-RADS, and the diagnostic validity of VI-RADS for predicting muscle invasion by BCa was analyzed based on histopathology of the first and/or second transurethral resection of bladder tumors and radical cystectomy. Receiver operating characteristic (ROC) curves were plotted with the calculation of area under the curves (AUCs), and the level of significance was P < 0.05. Both groups showed optimal performance with a VI-RADS score ≥ 3. BpMRI showed comparable diagnostic performance to mpMRI (reader 1: AUC, 0.903 [0.827–0.954] vs. 0.935 [0.884–0.968], p = 0.510; and reader 2: AUC, 0.901 [0.814–0.945] vs. 0.915 [0.874–0.946]; p = 0.655). The inter-reader agreement between both readers was excellent (Cohen’s kappa value = 0.942 and 0.905 for bpMRI and mpMRI, respectively). This comparative study suggests that bpMRI has comparable diagnostic performance to mpMRI and may be an alternative option to predict muscle invasion by BCa.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

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Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Noh

Shim

Kang

et al. 2022

Sci Rep

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“…But still, the fact that the bladder is swollen affects the accuracy of scans of the bladder wall and tumor. Patients with renal insufficiency or an allergy to iodine contrast agents face significant obstacles whenever it comes to enhanced CT/MRI 113 . Ultrasound imaging is very useful for screening for hematuria in patients with renal failure and iodine contrasts medium allergy.…”

Section: Bladder Cancer Diagnosismentioning

confidence: 99%

“…Patients with renal insufficiency or an allergy to iodine contrast agents face significant obstacles whenever it comes to enhanced CT/MRI. 113 Ultrasound imaging is very useful for screening for hematuria in patients with renal failure and iodine contrasts medium allergy. Although ultrasonography has a high rate of detection, its accuracy is low.…”

Section: Bladder Cancer Diagnosis 111 | Current Diagnosis Approaches ...mentioning

confidence: 99%

miRNAs involvement in the etiology and targeted therapy of bladder cancer: Interaction between signaling pathway

Sharma,

Malviya

2023

Precision Medical Sciences

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Bladder cancer (BC) accounts for roughly 3% of all cancer diagnoses in developed countries. The prognosis could be improved significantly if the cancer is detected and classified as either muscle‐invasive bladder cancer (MIBC) or non‐muscle‐invasive bladder cancer (NMIBC) as promptly as possible. A potential ray of hope for the treatment of BC has emerged with the rapid development of nanomedicine and microRNAs (miRNAs), which promise to have fewer adverse effects, more tumor‐inhibitory effects, and decreased drug resistance. The complex interplay between hereditary and environmental variables is the root cause of this malignancy. Gene expression can be regulated by miRNAs, which are small, non‐coding RNAs that can either prevent the translation of protein‐coding genes or cleave RNA transcripts at certain locations. Elevated genomics has enabled a more extensive investigation of miRNAs whose expression is considerably different in BC patients compared to healthy volunteers or between BC tumor tissues and peripheral tissues. miRNAs have recently been discovered to be important regulators of BC cell carcinogenicity. Inaccurate diagnoses and prolonged treatment delays are more likely to occur due to the current diagnostic process such as lack of sensitivity and specificity and poor image quality. Patients now have access to a plethora of treatment options, including but not limited to surgery, chemotherapy, immunotherapy, gene therapy, and other innovative medicines, and in some cases, combination therapies. BC is one of the deadliest and most disabling malignancies affecting the urinary tract. Cancer of the urinary bladder has a terrible propensity for being fatal. BC is an intricate illness whose development can be affected by multiple parameters. Standard treatments for BC increase prognosis and survival, although recurrence is a major concern for patients. miRNAs are naturally occurring, small RNA molecules that have been linked to cancer through their expression being dysregulated. miRNAs modulate many cellular activities including proliferation, migration, differentiation, and apoptosis. MiRNA dysregulation is recognized in BC, and miRNAs are used as diagnostic and prognostic indicators. However, this manuscript discusses the recent progress made in nanomedicine and the function of miRNAs in the pathogenesis and targeted therapy of BC.

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Novel utility of Vesical Imaging-Reporting and Data System in multimodal treatment for muscle-invasive bladder cancer

et al. 2023

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Diagnostic accuracy and discriminative power of biparametric versus multiparametric MRI in predicting muscle-invasive bladder cancer

Cited by 6 publications

References 39 publications

Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

miRNAs involvement in the etiology and targeted therapy of bladder cancer: Interaction between signaling pathway

Novel utility of Vesical Imaging-Reporting and Data System in multimodal treatment for muscle-invasive bladder cancer

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