Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection

Abstract

Objective: Describe the diagnosis, clinical course, and management of a dog with systemic Mycoleptodiscus indicus infection. Case Summary: A 5-year-old male neutered Giant Schnauzer presented with left eye anterior uveitis, peripheral lymphadenopathy, hyperglobulinemia, anemia, and thrombocytopenia. A diagnosis of M. indicus infection was made based on histopathology and PCR. Treatment with itraconazole and terbinafine resulted in resolution of the hyperglobulinemia, anemia, thrombocytopenia, and peripheral lymphadenopathy. No evidence of fungal organisms was identified on lymph node, liver, or ocular histopathology after 7 months of treatment. New or Unique Information Provided: This case is the first report of a systemic M. indicus infection in an apparently immunocompetent dog. Clinical resolution was achieved with systemic itraconazole and terbinafine.

Clinical utility of fungal culture and antifungal susceptibility in cats and dogs with histoplasmosis

“… 39 , 40 This drug combination, or terbinafine used as a sole agent, has been reported in animals with aspergillosis (systemic or sinonasal and sino‐orbital), various opportunistic invasive mold infections, sporotrichosis, and cryptococcosis. 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 Low MICs found in our study support further investigation of terbinafine as a sole agent, or in combination with another class of antifungal drug, for histoplasmosis in cats and dogs.…”

“…Reported use of terbinafine for invasive fungal infections in veterinary medicine has been primarily in combination with azoles, where in vitro data indicate synergism against certain organisms 39,40 . This drug combination, or terbinafine used as a sole agent, has been reported in animals with aspergillosis (systemic or sinonasal and sino‐orbital), various opportunistic invasive mold infections, sporotrichosis, and cryptococcosis 41‐49 . Low MICs found in our study support further investigation of terbinafine as a sole agent, or in combination with another class of antifungal drug, for histoplasmosis in cats and dogs.…”