Diagnosis of specialized intestinal metaplasia by optical coherence tomography

Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography

“…13 In contrast to this previous study, where tissue samples were taken randomly from the esophagus and the stomach, biopsy-correlated images in our study were performed only at the SCJ, thereby including a much higher proportion of image samples of gastric cardia and columnar epithelium. The proportional increase in columnar epithelium in this data set likely accounts for the differences in the determined sensitivities for SIM.…”

“…13,16 The light source center wavelength was 1300 nm, and the optical power incident on the tissue was 5.0 mW. The spectral bandwidth of the source was 70 nm, which provided an axial resolution of 10 μm.…”

“…11,12 A previous study demonstrated that OCT can distinguish SIM from squamous, fundic, and antral mucosa but can falsely identify gastric cardia as SIM. 13 This prior study used biopsy-correlated images obtained throughout the upper-GI tract and as a result did not address the accuracy of OCT specifically at the squamocolumnar junction (SCJ), which is the region where SIM is thought to originate.…”

Comprehensive esophageal microscopy by using optical frequency–domain imaging (with video)

“…[6][7][8]18 These criteria were specific to imaging with a catheter that did not compress the esophageal wall. It is unclear whether tissue compression arising from the balloon will adversely affect the accuracy of OCT diagnostic criteria; additional studies will be required.…”

Diffuse reflectance spectroscopy in Barrett’s Esophagus: developing a large field‐of‐view screening method discriminating dysplasia from metaplasia

“…Whereas conventional endoscopy is limited to detecting lesions based on gross morphological changes, several novel optically based technologies offer the potential of detecting the very earliest mucosal changes. Spectral techniques, particularly fluorescence [7,8] and narrow-band imaging [9], optical coherence tomography [10,11] laser scattering spectroscopy [12], Raman spectroscopy [13], microendoscopy [14], chromoendoscopy [15,16], chromomicroendoscopy [17] and infrared endoscopy [18] have all been investigated, with variable results. The spectral techniques are currently limited to pointby-point sampling only.…”