Diagnosis of soft-tissue masses with MR imaging: can benign masses be differentiated from malignant ones?

Crim, Julia R.; Seeger, Leanne L.; Yang, Lin; Chandnani, VP; Eckardt, Jeffery J.

doi:10.1148/radiology.185.2.1410377

Cited by 230 publications

(92 citation statements)

References 16 publications

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“…However, it has been shown that these criteria are not reliable indicators of malignancy and can be present in benign neuroˆbromas. 2,5,6 Recently, DWI has been used to detect and characterize tumors. DWI is a technique in which phase-defocusing and -refocusing gradients are used to evaluate the rate of microscopic water diŠu-sion within tissue.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted Imaging of Retroperitoneal Malignant Peripheral Nerve Sheath Tumor in a Patient with Neurofibromatosis Type 1

et al. 2008

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We present the diŠusion-weighted imaging (DWI)ˆndings for a malignant peripheral nerve sheath tumor arising in a retroperitoneal plexiform neuroˆbroma in a patient with neuroˆbromatosis type 1. Signal intensity of the malignant area was high on DWI and low on the apparent diŠusion coe‹cient map and diŠered fromˆndings for the benign area. DWI enabled clear diŠerentiation between malignant and benign areas of the tumor.

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Section: Discussionmentioning

confidence: 99%

Diffusion-weighted Imaging of Retroperitoneal Malignant Peripheral Nerve Sheath Tumor in a Patient with Neurofibromatosis Type 1

et al. 2008

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“…In our case, the mass had a well defined margin, and the initial impression was benign soft tissue mass. Because sharp margination is not a reliable point of differentiation between a benign and malignant neoplasm, sarcoma could not, however, be rule out (8). Probably because of the high cellularity of the central scar-like component, the target-like signal intensity seen at MR imaging varied.…”

Section: Discussionmentioning

confidence: 99%

“…In the pectoralis major muscle, a relatively welldemarcated spindle-shaped hypoechoic mass, 3.3 2. 8 1.4 cm in size and with roughly grouped muscle-like echogenicity and thick-lined echolucencies, was observed ( Fig. 1).…”

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confidence: 84%

Proliferative Myositis: A Case Report

Kim

Jeon

2002

J Korean Radiol Soc

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Proliferative myositis, a rare benign pseudosarcomatous lesion (1), usually appears as a rapidly growing mass in the proximal muscles of the extremities of adults. Clinically, it can be mistaken for a malignant tumor. Since it shows no tendency to recur, it is, however, probably self-limiting (2), and treatment by simple local excision is recommended. We present a case of proliferative myositis arising from the pectoralis muscle. Case ReportA 59-year-old man presented with a hard, tender, fixed palpable mass in the superolateral aspect of the left anterior chest wall near the anterior axillar fold. There was no history of trauma to the chest. Four years earlier he had become aware of the presence of a small lump in the left anterior chest wall, and recent rapid growth had occurred. Clinically, a sarcomatous muscular neoplasm

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“…37 Once cystic, lipomatous, and vascular lesions have been ruled out, it is estimated that the ability of MRI to accurately characterize lesions is low, often ,50%. [38][39][40][41] Patterns of contrast enhancement in benign and malignant lesions overlap, 38 and with DCE-MRI malignant lesions typically demonstrate rapid early arterial enhancement and higher slopes of enhancement compared with benign lesions, 15,[17][18][19] but this pattern is not entirely specific (Fig 3). Finally, MRS is an emerging technique that has recently been applied to the characterization of musculoskeletal tumors.…”

Section: Figurementioning

confidence: 99%

De Novo Assessment of Pediatric Musculoskeletal Soft Tissue Tumors: Beyond Anatomic Imaging

Ahlawat

Fayad

2015

Pediatrics

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MRI plays a central role in the assessment of pediatric musculoskeletal soft tissue tumors. Although these neoplasms may initially be evaluated on other modalities, such as sonography, MRI is essential for accurately determining the extent of disease. Traditionally, MRI has been performed with sequences that provide excellent anatomic detail, with T1-weighted, fluid-sensitive, and static postcontrast T1-weighted sequences. However, with the introduction of noncontrast sequences such as diffusion-weighted imaging and magnetic resonance spectroscopy to the arsenal of available MRI techniques, functional and metabolic features of a neoplasm can now be examined noninvasively. These more recent MRI methods offer information for lesion characterization, the assessment of treatment response, and the distinction of postoperative scar from recurrence. Dynamic contrast-enhanced perfusion imaging is another useful functional technique that can be acquired before conventional static postcontrast imaging, without requiring additional contrast material. This review presents recent advances in MRI methodology that enable a comprehensive clinical assessment of musculoskeletal tumors in the pediatric population. The roles and challenges of combining anatomic, functional, and metabolic MRI sequences will be discussed as they relate to newly discovered soft tissue tumors in children.A principal role for MRI in the evaluation of pediatric musculoskeletal tumors is the determination of extent of disease for appropriate preoperative planning. Diffusion-weighted imaging (DWI), dynamic contrast-enhanced perfusion imaging (DCE-MRI), and magnetic resonance spectroscopy (MRS) have expanded the role of MRI to include lesion characterization, treatment response, and the detection of postsurgical recurrence. In this review, conventional (anatomic sequences) and advanced (functional and metabolic sequences) imaging will be discussed, with an emphasis on how these sequences are used in the clinical setting of newly discovered (de novo) pediatric soft tissue tumors. The assessment of treatment response and postsurgical recurrence is beyond the scope of this article. CHALLENGES IN THE PEDIATRIC PATIENTPediatric imaging presents unique challenges that are not encountered in the adult setting. The need for sedation in young children requires that a comprehensive protocol also be succinct. A complete tumor protocol that includes anatomic, functional, and metabolic sequences has been previously described. 1 The examination requires 60 minutes, with 15 minutes of this time allotted to MRS if desired (see Table 1).Additional challenges encountered in pediatric patients include their small size with resultant decreased signal and inherently low scan resolution.

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Diagnosis of soft-tissue masses with MR imaging: can benign masses be differentiated from malignant ones?

Cited by 230 publications

References 16 publications

Diffusion-weighted Imaging of Retroperitoneal Malignant Peripheral Nerve Sheath Tumor in a Patient with Neurofibromatosis Type 1

Diffusion-weighted Imaging of Retroperitoneal Malignant Peripheral Nerve Sheath Tumor in a Patient with Neurofibromatosis Type 1

Proliferative Myositis: A Case Report

De Novo Assessment of Pediatric Musculoskeletal Soft Tissue Tumors: Beyond Anatomic Imaging

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