Diagnosis of renovascular hypertension: feasibility of captopril-sensitized dynamic MR imaging and comparison with captopril scintigraphy.

Grenier, N.; Trillaud, Hervé; Combe, Christian; Degrèze, Philippe; Jeandot, R.; Gosse, Philippe; Douws, C.; Palussière, Jean

doi:10.2214/ajr.166.4.8610560

Cited by 56 publications

(24 citation statements)

References 10 publications

(4 reference statements)

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“…While common clinical protocols call for injection of 5-20 mmol of DTPA (15,16), the relationship between the dose of the tracer and the accuracy of subsequent measurements has not been systematically analyzed. Our results suggest the feasibility of MR measurements using doses of Gd-DTPA that are several times lower than current standards.…”

Section: Discussionmentioning

confidence: 99%

Optimal dose of Gd‐DTPA in dynamic MR studies

Rusinek

Lee

Johnson

2001

Magnetic Resonance in Med

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Gadolinium contrast agents (such as gadopentetate dimeglumine, Gd-DTPA) combined with dynamic MR studies are increasingly used to measure physiological properties of biological systems. In a typical application, the concentration of Gd-DTPA is traced in vivo following intravenous administration. Since Gd shortens the relaxation time of nearby protons, the MR signal can be measured in tissue regions, converted to the absolute concentration, and the resulting time course analyzed, yielding functional parameters.The advantage of dynamic MRI with Gd-DTPA over iodinated contrast agents imaged with X-rays and scintigraphic studies includes a lack of radiation exposure and a low rate of adverse reaction. While the relationship between tracer dose and the accuracy of the measurements is well understood in nuclear medicine and CT imaging applications, little work has been devoted to analyze this relationship in dynamic MRI.We describe a method for computing the concentration c of the tracer from T 1 -weighted images that are characterized by large signal nonuniformities (such as torso phasedarray or surface coil images). For a wide range of values, c can be uniquely derived from measured MR signal S, the precontrast signal intensity SЈ, and the precontrast longitudinal relaxation time TЈ. We show how the fixed errors in measured variables propagate through computed parameters. Finally, based on realistic arterial and tissue response functions measured in both normal subjects and subjects with established renal insufficiency, we perform Monte Carlo simulations to optimize the dose of Gd-DTPA for two quantitative dynamic MR studies: 1) the measurement of cardiac output and 2) the measurement of glomerular filtration rate.

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Section: Discussionmentioning

confidence: 99%

Optimal dose of Gd‐DTPA in dynamic MR studies

Rusinek

Lee

Johnson

2001

Magnetic Resonance in Med

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“…Preliminary feasibility has been reported both in animal models (Fig. 4) (114) and in human subjects (44).…”

Section: K(t)] Is Given Bymentioning

confidence: 95%

“…A physiological imaging diagnosis of renal artery stenosis is currently made using angiotensin-converting enzyme inhibitor (ACE-I) renal scintigraphy and is arguably a good predictor of response to therapy (16,39). The signal intensity-time curves obtained with predominantly T 1 -weighted sequences (such as those used for acquiring contrast-enhanced MR angiography) can be used in concert with ACE inhibition to differentiate kidneys supplied by stenotic renal arteries (44,114).…”

Section: K(t)] Is Given Bymentioning

confidence: 99%

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Prasad

2006

American Journal of Physiology-Renal Physiology

106

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“…A significant linear correlation was found between extraction fraction measured with MRI vs. inulin [11]. Grenier et al [12] studied 15 hypertensive patients with renal artery stenosis and found that captopril-sensitized dynamic MRI of the kidney with a Gd3 + chelate was feasible in patients with renovascular hypertension. There was a good correlation between MR and nuclear renography, although captopril-induced changes were not seen in all patients shown to have the disease.…”

Section: Dynamic Serial Gadolinium-enhanced Mrimentioning

confidence: 99%

Magnetic Resonance Imaging in Acute and Chronic Kidney Diseases: Present Status

Laissy¹,

Idée

Fernandez³

et al. 2006

Nephron Clin Pract

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Magnetic resonance imaging (MRI) of normal and diseased kidneys shows great promise because of the combined value of anatomical and functional information provided, as well as of specific contrast patterns that can be observed non-invasively. Multicontrast MRI is able to show infiltrative kidney disorders. Diffusion-weighted imaging can assess alterations in renal function and can suggest obstruction or inflammation when present. Due to the low nephrotoxicity, contrast-enhanced MR studies using serial dynamic enhancement with non-specific gadolinium chelates are able to provide information on glomerular filtration. Furthermore, contrast agents such as ultrasmall particles of iron oxide, specific of inflammation, should be used in the near future to detect active from quiescent involvement, both in native kidneys and renal allografts. Early results should indicate that these compounds might differentiate acute tubular necrosis from other acute nephropathies, as well as active proliferative nephropathies from chronic ones. Ongoing studies will obviously demonstrate the value of the combination of these various MRI sequences in the diagnosis of acute renal failure and chronic kidney disease.

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Diagnosis of renovascular hypertension: feasibility of captopril-sensitized dynamic MR imaging and comparison with captopril scintigraphy.

Cited by 56 publications

References 10 publications

Optimal dose of Gd‐DTPA in dynamic MR studies

Optimal dose of Gd‐DTPA in dynamic MR studies

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Magnetic Resonance Imaging in Acute and Chronic Kidney Diseases: Present Status

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