Diagnosis of Orbital Cavernous Hemangioma With Tc-99m RBC SPECT

Ki, Won Woo; Shin, Jüng Woo; Won, Kyoung Sook; Ryu, Jin Sook; Yang, Seoung-Oh; Lee, Hee Kyung; Kim, Yong Jae

doi:10.1097/00003072-199708000-00007

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…Tc red blood cells is commonly used in the evaluation of hepatic hemangiomas and may also be used in the noninvasive evaluation of extrahepatic vascular lesions such as vascular tumors of the orbit, [13][14][15][16][17][18] as well as in gastrointestinal bleeding imaging, cardiacgated blood pool studies, and radionuclide venograms.…”

Section: Scintigraphy With 99mmentioning

confidence: 99%

“…This assertion is borne out by several studies reported in the literature. [13][14][15][16][17] Moreover, we may assert that patients with an AI greater than 5.0 are almost certainly affected by cavernous hemangioma. Patients with an AI between 5.0 and 2.0 are likely to be affected by a vascular tumor (hemangiopericytoma, lymphangioma, or cavernous hemangioma).…”

Section: Scintigraphy With 99mmentioning

confidence: 99%

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Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Polito

Burroni²,

Pichierri³

et al. 2005

Arch Ophthalmol

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To evaluate technetium Tc 99m (99m Tc) red blood cell scintigraphy as a diagnostic tool for orbital cavernous hemangioma and to differentiate between orbital masses on the basis of their vascularization. Methods: We performed 99m Tc red blood cell scintigraphy on 23 patients (8 female and 15 male; mean age, 47 years) affected by an orbital mass previously revealed with computed tomography (CT) and magnetic resonance imaging (MRI) and suggesting cavernous hemangioma. In our diagnosis, we considered the orbital increase delayed uptake with the typical scintigraphic pattern known as perfusion blood pool mismatch. The patients underwent biopsy or surgical treatment with transconjunctival cryosurgical extraction when possible. Results: Single-photon emission tomography (SPET) showed intense focal uptake in the orbit corresponding to radiologic findings in 11 patients who underwent surgical treatment and pathologic evaluation (9 cavernous hemangiomas, 1 hemangiopericytoma, and 1 lymphangioma). Clinical or histologic examination of the remaining 22 patients revealed the presence of 5 lymphoid pseudotumors, 2 lymphomas, 2 pleomorphic adenomas of the lacrimal gland, 1 astrocytoma, 1 ophthalmic vein thrombosis, and 1 orbital varix. Conclusions: The confirmation of the preoperative diagnosis by 99m Tc red blood cell scintigraphy shows that this technique is a reliable tool for differentiating cavernous hemangiomas from other orbital masses (sensitivity,100%; specificity,86%) when ultrasound, CT, and MRI are not diagnostic. Unfortunately, 99m Tc red blood cell scintigraphy results were positive in 1 patient with hemangiopericytoma and 1 patient with lymphangioma, which showed increased uptake in the lesion on SPET images because of the vascular nature of these tumors. Therefore, in these cases, the SPET images have to be integrated with data regarding clinical preoperative evaluation and CT scans or MRI studies. On the basis of our study, a complete diagnostic picture, CT scans or MRI studies, and scintigraphic patterns can establish the preoperative diagnosis of vascular orbital tumors such as cavernous hemangioma, adult-type lymphangioma, and hemangiopericytoma.

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Section: Scintigraphy With 99mmentioning

confidence: 99%

Section: Scintigraphy With 99mmentioning

confidence: 99%

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Polito

Burroni²,

Pichierri³

et al. 2005

Arch Ophthalmol

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“…[ 99m Tc] is broadly available but the image quality and quantitative accuracy of Single‐photon emission computed tomography (SPECT) are poorer than those of PET imaging. Autologous [ 99m Tc]‐labeled erythrocytes have been used to characterize liver hemangiomas or for the differential diagnosis of orbital cavernous hemangiomas . Additionally, this methodology has been used to identify hemangiomatous lesions in other localizations such as vertebra , spleen and cavernous sinus .…”

Section: Introductionmentioning

confidence: 99%

Erythrocytes labeled with [¹⁸F]SFB as an alternative to radioactive CO for quantification of blood volume with PET

Herance

Gispert²,

Abad

et al. 2013

Contrast Media & Molecular

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Inhaled radioactive CO is currently the tracer of choice for blood volume quantification by positron emission tomography (PET). This measurement is of great interest for several clinical and research applications. However, owing to the short half-life of the radiolabeled CO, it can only be used in centers equipped with a cyclotron. In the present work, we propose an alternative method to label the red blood cells with [(18) F] in order to obtain blood volume measurements by PET. The use of the radioactive synthon [(18) F] N-succinimidyl 4-[(18) F]fluorobenzoate ([(18) F]SFB) was evaluated for erythrocyte labeling and PET blood volume imaging. The images provided by [(18) F]SFB labeled erythrocytes were compared with those obtained with inhaled [(11) C]CO. Blood volumes obtained with [(18) F]SFB labeled erythrocytes were similar to those obtained with [(11) C]CO in all of the evaluated organs with the exception of spleen, which presented lower uptake with this method. Since the [(18) F]-SFB binds irreversibly to red blood cells, in vivo stability of the radiolabel was higher compared with the [(11) C]CO method. Additionally, owing to the longer half-life and the shorter positron range of [(18) F], the image quality was also higher with the [(18) F]SFB radiolabeled erythrocytes. The labeling of red blood with [(18) F]SFB represents an advantageous alternative to radioactive CO for blood volume measurement by PET and cardiovascular isotopic imaging.

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“…From then onwards, over the past 16 years, we have used Tc-99m RBC scintigraphy routinely to confirm the diagnosis of orbital cavernous hemangioma whenever it was suspected on CT scan. Following our initial work, 3 cases of orbital cavernous hemangioma which were diagnosed by nuclear medicine techniques using red blood cells were recently published (6,7 ).…”

Section: Introductionmentioning

confidence: 99%

Tc-99m Labeled Red Blood Cells Scintigraphy: A Diagnostic Method for Orbital Cavernous Hemangioma

Gdal-On

Gelfand

Israel

1999

European Journal of Ophthalmology

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Diagnosis of Orbital Cavernous Hemangioma With Tc-99m RBC SPECT

Cited by 11 publications

References 7 publications

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Erythrocytes labeled with [¹⁸F]SFB as an alternative to radioactive CO for quantification of blood volume with PET

Tc-99m Labeled Red Blood Cells Scintigraphy: A Diagnostic Method for Orbital Cavernous Hemangioma

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Diagnosis of Orbital Cavernous Hemangioma With Tc-99m RBC SPECT

Cited by 11 publications

References 7 publications

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Erythrocytes labeled with [18F]SFB as an alternative to radioactive CO for quantification of blood volume with PET

Tc-99m Labeled Red Blood Cells Scintigraphy: A Diagnostic Method for Orbital Cavernous Hemangioma

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Erythrocytes labeled with [¹⁸F]SFB as an alternative to radioactive CO for quantification of blood volume with PET