Tc-99m Labeled Red Blood Cells Scintigraphy: A Diagnostic Method for Orbital Cavernous Hemangioma

Gdal-On, M; Gelfand, Yuval A; Israel, Ora

doi:10.1177/112067219900900209

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…Tc red blood cells is commonly used in the evaluation of hepatic hemangiomas and may also be used in the noninvasive evaluation of extrahepatic vascular lesions such as vascular tumors of the orbit, [13][14][15][16][17][18] as well as in gastrointestinal bleeding imaging, cardiacgated blood pool studies, and radionuclide venograms.…”

Section: Scintigraphy With 99mmentioning

confidence: 99%

“…These 2 cases displayed increased uptake within the lesion on SPET images (AI=4.94 and 3.68, respectively), which is probably due to the vascular nature of these tumors. 18 Therefore, in these cases the SPET images need to be integrated with data regarding clinical preoperative evaluation (anamnestic evaluation of onset and pain, careful palpation of the globe, and ocular motility study) and CT scans or MRI studies.…”

Section: Scintigraphy With 99mmentioning

confidence: 99%

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Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Polito

Burroni²,

Pichierri³

et al. 2005

Arch Ophthalmol

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To evaluate technetium Tc 99m (99m Tc) red blood cell scintigraphy as a diagnostic tool for orbital cavernous hemangioma and to differentiate between orbital masses on the basis of their vascularization. Methods: We performed 99m Tc red blood cell scintigraphy on 23 patients (8 female and 15 male; mean age, 47 years) affected by an orbital mass previously revealed with computed tomography (CT) and magnetic resonance imaging (MRI) and suggesting cavernous hemangioma. In our diagnosis, we considered the orbital increase delayed uptake with the typical scintigraphic pattern known as perfusion blood pool mismatch. The patients underwent biopsy or surgical treatment with transconjunctival cryosurgical extraction when possible. Results: Single-photon emission tomography (SPET) showed intense focal uptake in the orbit corresponding to radiologic findings in 11 patients who underwent surgical treatment and pathologic evaluation (9 cavernous hemangiomas, 1 hemangiopericytoma, and 1 lymphangioma). Clinical or histologic examination of the remaining 22 patients revealed the presence of 5 lymphoid pseudotumors, 2 lymphomas, 2 pleomorphic adenomas of the lacrimal gland, 1 astrocytoma, 1 ophthalmic vein thrombosis, and 1 orbital varix. Conclusions: The confirmation of the preoperative diagnosis by 99m Tc red blood cell scintigraphy shows that this technique is a reliable tool for differentiating cavernous hemangiomas from other orbital masses (sensitivity,100%; specificity,86%) when ultrasound, CT, and MRI are not diagnostic. Unfortunately, 99m Tc red blood cell scintigraphy results were positive in 1 patient with hemangiopericytoma and 1 patient with lymphangioma, which showed increased uptake in the lesion on SPET images because of the vascular nature of these tumors. Therefore, in these cases, the SPET images have to be integrated with data regarding clinical preoperative evaluation and CT scans or MRI studies. On the basis of our study, a complete diagnostic picture, CT scans or MRI studies, and scintigraphic patterns can establish the preoperative diagnosis of vascular orbital tumors such as cavernous hemangioma, adult-type lymphangioma, and hemangiopericytoma.

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Section: Scintigraphy With 99mmentioning

confidence: 99%

Section: Scintigraphy With 99mmentioning

confidence: 99%

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Polito

Burroni²,

Pichierri³

et al. 2005

Arch Ophthalmol

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“…In some studies, this typical appearance of these tumors was used for the differentiation from malignant tumors and confirmed with histopathology (5). According to previous reports, Tc 99m labeled erythrocyte imaging could differentiate hemangioma from malignant tumors (5,8,9,10). This characteristic of Tc 99m labeled erythrocyte scintigraphy might help to decide the choice of treatment, i.e.…”

Section: Discussionmentioning

confidence: 80%

“…Radioactivity accumulation within the lesion of our patient was very prominent in the late phase images. The scintigraphic pattern of the hemangioma which is hypoactive in the vascular phase and hyperactive in the late phase, is previously well established (8,9,10). In some studies, this typical appearance of these tumors was used for the differentiation from malignant tumors and confirmed with histopathology (5).…”

Section: Discussionmentioning

confidence: 94%

A Case of Intraorbital Hemangioma Diagnosed with Tc 99m Labeled Erythrocyte Scintigraphy and Magnetic Resonance Imaging

Balcı¹,

Koc²,

Turgut³

et al. 2011

Mirt

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We present a 20 year-old male patient who had prominent positional proptosis of the right eye and admitted to the hospital for tonsillectomy operation. After conventional ophthalmological examination, magnetic resonance imaging (MRI) and Tc 99m labeled erythrocyte scintigraphy were performed to confirm the diagnosis. Although it is rare to perform scintigraphy for this pathology, the visualization of intraorbital hemangioma was very obvious and we would like to present the visualization of the intraorbital hemangioma both with scintigraphy and MRI. Conflict of interest:None declared.

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“…Sayit et al 9 reported that, in all patients with OCH whom they studied, the preoperative diagnosis was confirmed by the typical pattern of perfusion blood pool mismatch on the 99m Tc-RBC scintigraphy. Gdal-On et al 10 performed 99m Tc-RBC scintigraphy on 12 patients with OCH, all of whom were confirmed by means of histology. Polito et al 11 performed 99m Tc-RBC scintigraphy on 23 patients affected by an orbital mass previously revealed with CT and MRI and suggesting cavernous hemangioma.…”

Section: Discussionmentioning

confidence: 99%

The application of technetium-99m-red blood cell scintigraphy in the diagnosis of orbital cavernous hemangioma

Hua

Zhang

Guo

et al. 2017

Nuclear Medicine Communications

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ObjectiveThe purpose of this study was to evaluate the clinical value of technetium-99m-red blood cell (99mTc-RBC) scintigraphy in the diagnosis of orbital cavernous hemangioma (OCH).Patients and methodsForty-one patients with pathologically confirmed orbital mass, of which 10 were OCH, underwent 99mTc-RBC scintigraphy in this study. The scanning procedure included an initial perfusion phase, followed by an early and a delayed blood pool phase. All patients underwent ultrasonography and computed tomography (CT), and 15 patients also underwent MRI.ResultsAll 10 OCH patients had no abnormal findings on radionuclide angiographic images and early blood pool phase, but increased activity was found during delayed blood pool phase. All other non-OCH orbital tumours did not have this tracer pattern. The radioactivity ratios of tumour to nontumour were 2.96±0.05 and 1.14±0.25, respectively, which had a statistically significant difference (t=15.18, P<0.001). Although nine of 10 OCH patients were diagnosed correctly with one false-positive case using ultrasound, both CT and MRI could not provide a definitive diagnosis.Conclusion99mTc-RBC scintigraphy is a reliable and useful procedure for the diagnosis of OCH. It may be considered as one of the routine clinical screening tools for the diagnosis of OCH and as a complement investigation to ultrasonography and CT.

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Tc-99m Labeled Red Blood Cells Scintigraphy: A Diagnostic Method for Orbital Cavernous Hemangioma

Abstract: Tc-99m RBC scintigraphy is a reliable method for diagnosing orbital cavernous hemangioma. It should be included in our arsenal of diagnostic techniques, particularly for cases which are otherwise difficult to diagnose.

Cited by 10 publications

References 9 publications

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

Technetium Tc 99m–Labeled Red Blood Cells in the Preoperative Diagnosis of Cavernous Hemangioma and Other Vascular Orbital Tumors

A Case of Intraorbital Hemangioma Diagnosed with Tc 99m Labeled Erythrocyte Scintigraphy and Magnetic Resonance Imaging

The application of technetium-99m-red blood cell scintigraphy in the diagnosis of orbital cavernous hemangioma

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