Diagnosis of Nonmelanoma Skin Cancer/Keratinocyte Carcinoma: A Review of Diagnostic Accuracy of Nonmelanoma Skin Cancer Diagnostic Tests and Technologies

Mogensen, Mette; Jemec, Gregor B. E.

doi:10.1111/j.1524-4725.2007.33251.x

Cited by 154 publications

(184 citation statements)

References 122 publications

(100 reference statements)

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“…It has been reported that PpIX fluorescence does not have absolute correlation to PDT outcomes 11,12 , yet it has been successfully used to detect early stages of malignant changes in the skin 29,9,30 . Measurement of fluorescence is the most widely used method employed for non-invasive in-vivo imaging of PpIX metabolism, which in turn may be used as a surrogate to optimise PDT parameters.…”

Section: Ppix Fluorescence Patterns Of Ak and Bcc Lesions And Where Pmentioning

confidence: 99%

“…In [24] 54 lesions (21 BCCs, 22 AK, and 11 seborrheic keratosis SK) were used in the study to establish if auto-fluorescence combined with PpIX assisted fluorescence can be used for optical detection of NMSC. ALA solution was applied to the lesions and the fluorescence was imaged at 15,30,45 and 60 minutes in a dark room. They found noticeable differences between the autofluorescence in healthy and diseased skin; PpIX fluorescence increased the contrast at the lesion margins.…”

Section: Introductionmentioning

confidence: 99%

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Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Kulyk

Ibbotson

Moseley

et al. 2015

Photodiagnosis and Photodynamic Therapy

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3 HighlightsWe developed a handheld device and a time course method for fluorescence imagingThe device can be used to study PpIX formation in healthy and diseased skin PpIX fluorescence grows throughout the 3 hours prior to treatmentThe fluorescence intensity varies between diagnoses and individuals The fluorescence depends on the body site, possibly due to differences in temperature 4 Abstract Background

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Section: Ppix Fluorescence Patterns Of Ak and Bcc Lesions And Where Pmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Kulyk

Ibbotson

Moseley

et al. 2015

Photodiagnosis and Photodynamic Therapy

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“…Although MMS provides the highest cure rates (6), the lengthy (1-2 h per layer) and costly tissue preparation procedures required for intraoperative evaluation of the excised tissues by frozen-section histopathology have limited the wider use of MMS. Apart from being time consuming, the current histopathologic methods can provide only a subjective evaluation, leading to variability in diagnosis (9,10). These drawbacks have limited the use of traditional histopathology mostly to tissue-conserving surgery of nonmelanoma skin cancers, and this technique remains impractical for most other cancer types.…”

mentioning

confidence: 99%

Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy

Kong

Rowlands

Varma

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

221

223

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Tissue-conserving surgery is used increasingly in cancer treatment. However, one of the main challenges in this type of surgery is the detection of tumor margins. Histopathology based on tissue sectioning and staining has been the gold standard for cancer diagnosis for more than a century. However, its use during tissue-conserving surgery is limited by time-consuming tissue preparation steps (1-2 h) and the diagnostic variability inherent in subjective image interpretation. Here, we demonstrate an integrated optical technique based on tissue autofluorescence imaging (high sensitivity and high speed but low specificity) and Raman scattering (high sensitivity and high specificity but low speed) that can overcome these limitations. Automated segmentation of autofluorescence images was used to select and prioritize the sampling points for Raman spectroscopy, which then was used to establish the diagnosis based on a spectral classification model (100% sensitivity, 92% specificity per spectrum). This automated sampling strategy allowed objective diagnosis of basal cell carcinoma in skin tissue samples excised during Mohs micrographic surgery faster than frozen section histopathology, and one or two orders of magnitude faster than previous techniques based on infrared or Raman microscopy. We also show that this technique can diagnose the presence or absence of tumors in unsectioned tissue layers, thus eliminating the need for tissue sectioning. This study demonstrates the potential of this technique to provide a rapid and objective intraoperative method to spare healthy tissue and reduce unnecessary surgery by determining whether tumor cells have been removed.

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“…22 Yapılan gözden geçirme çalışmaları sonucunda fizik muayenenin NMCK tanısı konulmasındaki sensitivitesi %56-90 arasında tespit edilmiş olup, aradaki bu fark klinisyenin tecrübesine bağlıdır. 23 Klinik incelemenin sensitivitesi bazal hücreli karsinomların tanısında %75-90'a kadar çıkmaktadır. 23 Her ne kadar NMCK tanısının konulmasında altın standart histopatolojik inceleme olsa da NMCK'nın artan insidansı nedeni ile araştırmacılar daha az invaziv, kolay, hızlı, daha ucuz, tanı ve takipte kullanılabi-len yöntemler aramaktadır.…”

Section: Bulgularunclassified

Evaluation of the Cases Who Were Referred to Plastic Surgery Clinic Out of Suspicion of Non-melanoma Skin Cancer Localized at Head and Neck Region in Sivas Numune Hospital

Derebaşınlıoğlu¹,

Özkaya²,

Parlak³

2016

Turkiye Klinikleri J Dermatol

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Ö ÖZ ZE ET T A Am ma aç ç: : Sivas Numune Hastanesi Plastik Cerrahi Polikliniğine baş-boyun bölgesi yerleşimli nonmelanositik cilt kanseri ön tanısıyla konsülte edilen ve eksizyonel biyopsi uygulanan hastalarda yaş, tutulan bölge, lezyon türleri ve kullanılan rekonstrüksiyon tekniklerini belirleyebilmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 1 Ocak 2013-1 Aralık 2014 tarihleri arasında Sivas Numune Hastanesi Plastik Rekonstrüktif ve Estetik Cerrahi Polikliniğine baş-boyun bölgesine yerleşimli nonmelanositik cilt kanseri ön tanısıyla konsülte edilen 163 hastaya yapılan 176 eksizyonel biyopsinin patolojik sonuçları incelenmiştir. B Bu ul lg gu ul la ar r: : Çalış-mamızda incelenen 163 hastanın 80 (%49,07)'ini erkekler, 83 (%50,9)'ünü ise kadınlar oluşturmakta idi. Ortalama yaş 60,4 olarak tespit edildi. Çalışmaya alınan 176 eksizyonel biyopsi sonucunun 105 (%59,6)'ini bazal hücreli karsinom, 14 (%7,9)'ünü skuamöz hücreli karsinom, 5 (%2,8)'ini bazoskuamöz hücreli karsinom, 25 (%14,2)'ini seboreik keratoz, 6 (%3,4)'sını aktinik keratoz, 18 (%10,2)'ini keratoakantom, 1 (%0,56)'ini rüptüre epidermal kist, 1 (%0,56)'ini inflamasyon, 1 (%0,56)'ini granülasyon dokusu oluştur-makta idi. Nonmelanositik cilt kanserinin en sık görülen lokalizasyonu burun idi. S So on nu uç ç: : Çalışmamızda toplam 163 baş-boyun bölgesine lokalize nonmelanositik cilt kanseri ön tanısyla dermatoloji kliniğinden konsülte edilen hastalardan yapılan 176 eksizyonel biyopsi sonucunda 124 (%70,4) adet nonmelanositik cilt kanseri tespit edilirken, 24 (%13,6) adet premalign lezyon saptanmıştır. En sık görülen nonmelanositik cilt kanseri bazal hücreli karsinom olurken, ikinci sıklıkla skuamöz hücreli karsinom görülmüştür. Sonuç olarak, nonmelanositik cilt kanserleri şüphesi olan lezyonlara %70,4 oranında klinik olarak doğru malignite tanısı konulmuştur.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Karsinom, bazal hücre; karsinom, skuamöz hücre; baş ve boyun neoplazileri; patoloji A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : We aimed to determine age, gender, localization area and types of lesions and reconstruction tecniques, suspicion of nonmelanoma skin cancer cases who were consulted from dermatology clinic localizated at head and neck. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Retrospective review of 163 patients undergoing exicion biopsy at the Sivas Numune Hospital Plastic Reconstructive Surgery Clinic for suspicion of nonmelanoma skin cancer localized at head and neck region, between January 2013 and December 2014 was undertaken. 176 excision material of 163 cases were searched. R Re es su ul lt ts s: : In this study 163 patients (80; 49.07% males, 83; 50,9% females) were evaluated. Average of year was 60,4. Of the 175 exision material; 105 (60 %) were basal cell carcinoma, 13 (14.2%) were squamous cell carcinoma, 5 (2.8%) were basosquamous cell carcinoma, 25 (14.2%) were seboreic keratosis, 18 (10.2%) were keratoacanthoma, 6 (3.4%) were actinic keratosis, 1 (0.57%) was ruptured epider...

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Diagnosis of Nonmelanoma Skin Cancer/Keratinocyte Carcinoma: A Review of Diagnostic Accuracy of Nonmelanoma Skin Cancer Diagnostic Tests and Technologies

Abstract: Some of these new imaging technologies have the capability of providing new, three-dimensional in vivo, in situ understanding of NMSC development over time. Some of the new technologies described here have the potential to make it from the bench to the clinic.

Cited by 154 publications

References 122 publications

Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy

Evaluation of the Cases Who Were Referred to Plastic Surgery Clinic Out of Suspicion of Non-melanoma Skin Cancer Localized at Head and Neck Region in Sivas Numune Hospital

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