Diagnosis of Malignant Granular Cell Tumor by Fine Needle Aspiration Cytology

Diagnosis of Malignant Granular Cell Tumor Metastatic to Bone by Fine Needle Aspiration Cytology

“…9,10 The cytologic features of a metastatic focus would be expected, as was illustrated by Geisenger et al, 8 to show features of GCT, with at least a minority of the cells demonstrating nuclear atypia and mitotic activity. In the case reported by Liu et al, 3 FNA findings in aspirates of malignant GCT metastatic to a supraclavicular lymph node and liver revealed a high N:C ratio, vesicular nuclei with prominent nucleoli, pleomorphism and increased mitotic activity. These factors allowed the classification of the aspirate as malignant based solely on the cytologic features, independent of the metastatic nature of the tumor.…”

“…2 The diagnosis of malignant GCT is generally made when regional or distant metastases are present. 3 Histopathologically, primary malignant GCTs usually exhibit cytologic atypia, increased mitoses and necrosis. Metastatic GCTs most commonly occur in lymph nodes, lung, liver and bone, with most appearing several years after the initial diagnosis.…”

Lymph Node Metastasis of Soft Tissue Tumors

“…11,12 This is the rarest of all sarcomas, with only a single case report available in the world literature describing its cytomorphology. 13 The patient was a 46-year-old woman with a midarm swelling with a synchronously enlarged axillary lymph node; 3-4 smears from the primary site were cellular, but lymph node aspirate showed only a few scattered cells. A cytologic diagnosis of malignancy was not possible 14 ; however, lymph node metastases are the only proof of malignancy in these cases and help in the diagnosis.…”

Fine-needle aspiration cytology of granular cell tumor: A report of two cases

“…Other sites are chest wall, upper extremities, skin and subcutaneous tissue, vulva, breast, larynx, bronchus, gastrointestinal tract, anus, bile ducts, pancreas, urinary bladder, uterus, brain, pituitary gland and soft tissues. [2]…”