Diagnosis of Malignant Granular Cell Tumor Metastatic to Bone by Fine Needle Aspiration Cytology

Canacci, Anastasia M.; Nunez, Carlos; Getty, Patrick J.; Abdul‐Karim, Fadi W.

doi:10.1159/000325007

Cited by 9 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scanty lymphoid cells were seen but not in sufficient numbers to confirm aspiration from a lymph node. No morphological features of malignancy (nuclear atypia, mitotic activity and necrosis) were seen in the FNA specimen, but similar bland appearances have been documented during cytological examination of malignant granular cell tumors previously . In view of this and the patient's past history, the FNA was reported as showing metastatic granular cell tumor.…”

Section: Report Of a Patientsupporting

confidence: 74%

A case of metastatic non‐neural granular cell tumor in a 13‐year‐old girl

et al. 2014

View full text Add to dashboard Cite

Conventional granular cell tumor represents a mesenchymal neoplasm observed in a variety of locations and is now believed to be of Schwann cell origin. Granular cell change has also been observed in a variety of different tumors, but recently described in the skin has been a distinct entity termed non-neural granular cell tumor, which lacks expression of S100 protein and is of uncertain histogenesis. This tumor typically displays a greater degree of nuclear atypia and mitotic activity than conventional granular cell tumor but appears to behave in a relatively benign fashion, as only two previous instances of lymph node metastasis have been documented. Herein, we report a case of non-neural granular cell tumor arising on the back of a 13-year-old girl, and later axillary lymph node metastasis with extracapsular extension was observed.

show abstract

Section: Report Of a Patientsupporting

confidence: 74%

A case of metastatic non‐neural granular cell tumor in a 13‐year‐old girl

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Granular cell tumors, first described by Abrikossoff in 1926, are uncommon tumors of Schwannian cell origin . GCT can occur at a wide variety of sites but are most common in the head and neck region, especially the tongue, followed by the chest wall and upper extremities . Lesions at multiple sites have been reported in approximately 10‐15% of patients .…”

Section: Introductionmentioning

confidence: 99%

“…Malignant granular cell tumor (MGCT) is a well‐established entity representing <1‐2% of all GCT . By convention, a GCT is considered malignant when a morphologically benign GCT metastasizes to regional lymph nodes or to distant sites .…”

Section: Introductionmentioning

confidence: 99%

“…GCT can occur at a wide variety of sites but are most common in the head and neck region, especially the tongue, followed by the chest wall and upper extremities. 5 Lesions at multiple sites have been reported in approximately 10-15% of patients. 1 They are characterized by granular, acidophilic cytoplasm that reflects the presence of secondary lysosomes, and thus stains strongly for S-100 protein and neuron specific enolase.…”

mentioning

confidence: 99%

“…6 Malignant granular cell tumor (MGCT) is a well-established entity representing <1-2% of all GCT. 1,5,6 By convention, a GCT is considered malignant when a morphologically benign GCT metastasizes to regional lymph nodes or to distant sites. 4 Fanburg-Smith et al assessed six histologic criteria to characterize MGCTs from their benign counterparts: necrosis, spindling, vesicular nuclei with large nucleoli, increased mitotic activity (>2 mitoses/10 high-power fields at ×200 magnification), high nuclear to cytoplasmic (N:C) ratio, and pleomorphism.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Metastatic granular cell tumor to the breast diagnosed by fine needle aspiration cytology: A case report with review of the literature

Mir

Alnajar

Rohra

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

Granular cell tumors (GCT) are mesenchymal neoplasms of Schwann cell/neural origin. Malignant granular cell tumors (MGCTs) represent <1‐2% of all GCT and defined as tumors demonstrating metastases or destructive local growth. Other clinical parameters suggestive of malignancy include rapid growth, size > 4 cm and necrosis. An apparently inconsistent set of histological features have been described in MGCT. Although the histologic parameters of a GCT are not always predictive of biologic behavior, the presence of atypical features may be indicative of an aggressive clinical behavior (recurrence and metastases). A preoperative estimate of features suggestive of malignancy is important for treatment and prognostication. Diagnosis and prognostication from preoperative fine needle aspiration (FNA) cytology is hampered by the fact that only a few case reports on cytologic features of malignant GCT have been published. We report a case of metastatic MGCT to breast and compare cytologic features to that of primary breast GCT and apocrine/histiocytoid variants of breast carcinoma.

show abstract

Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis

Enomoto

Terasaki

Murase

et al. 2022

Diagnostic Cytopathology

View full text Add to dashboard Cite

Malignant granular cell tumors (GCTs) account for less than 2% of all GCTs and mainly occur in the deep soft tissue of the thigh or trunk. Malignant GCTs are highly aggressive tumors with high rates of recurrence and metastasis. In this brief report, we describe a rare case of malignant GCT in a 64‐year‐old Japanese man who presented with a 14 × 20 cm mass in the left inguinal region. The cytologic findings of fine‐needle aspiration (FNA) revealed atypical epithelial‐like granular cells with granular substance in the background, which was difficult to differentiate from apocrine carcinoma or melanoma. The immunohistochemistry (IHC) findings of the needle biopsy revealed that the tumor cells were positive for S‐100 and lysosomal marker CD68 which was suggestive of a GCT. However, the presence of crush artifacts made it challenging to identify cellular atypia, which is a characteristic of malignant tumor. Taken together, the FNA and needle biopsy results were suggestive of malignant GCT. The importance of preoperative diagnosis of malignant GCT is well known, but few reports have described its cytological findings. In our brief report, we show that combining cytological FNA and biopsy findings with IHC findings achieves an accurate diagnosis of malignant GCT.

show abstract

Diagnosis of Malignant Granular Cell Tumor Metastatic to Bone by Fine Needle Aspiration Cytology

Cited by 9 publications

References 8 publications

A case of metastatic non‐neural granular cell tumor in a 13‐year‐old girl

A case of metastatic non‐neural granular cell tumor in a 13‐year‐old girl

Metastatic granular cell tumor to the breast diagnosed by fine needle aspiration cytology: A case report with review of the literature

Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis

Contact Info

Product

Resources

About