Diagnosis of Lyme Disease

Pitrak, David; Nguyen, Cynthia T; Cifu, Adam S.

doi:10.1001/jama.2022.0081

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Serological testing for antibodies is only recommended to support clinical suspicion in patients with symptoms or signs consistent with LD. Serology is recommended to be performed in two steps, and an enzyme immunoassay (ELISA) can be performed as the first step; if positive or indeterminate, it must be followed by a confirmatory western blot, which requires correct interpretation of positive bands [ 48 ]. For the diagnosis of neuroborreliosis, the clinical picture combined with the serology collected from the blood is usually enough to make the diagnosis of the neurological involvement caused by LD, and the collection of cerebrospinal fluid (CSF) is not necessary unless the objective is to rule out other pathologies [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Facial Paralysis Due to Brazilian Lyme Disease: A Case Report and Literature Review

Levischi Jr

2023

Cureus

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Lyme disease (LD) is a highly prevalent infection in the northern hemisphere, with an estimated incidence of 450,000 new annual cases in the United States and 65,000 new annual cases in Europe. Transmitted by the bite of a tick contaminated with a spirochete, the disease has three distinct stages. In the second phase of the disease, there may be neurological impairment, and the involvement of cranial nerve pairs occurs in this phase. Neuropathy of the seventh cranial nerve can occur in around 10% of adults with neurological involvement by Borrelia; in children, this incidence can reach 50%. A 32-year-old female patient presented with an abrupt facial paralysis that evolved into a difficult-to-resolve condition. With the appearance of probable contralateral involvement, LD was diagnosed. After the established treatment, the patient presented a good evolution of the symptoms.

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Section: Discussionmentioning

confidence: 99%

Facial Paralysis Due to Brazilian Lyme Disease: A Case Report and Literature Review

Levischi Jr

2023

Cureus

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“…Details about the commission and development of this guideline (Table) were discussed in the previous synopsis of this guideline …”

Section: Characteristics Of the Guideline Sourcementioning

confidence: 99%

Prevention and Treatment of Lyme Disease

Nguyen

Cifu

Pitrak

2022

JAMA

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“…Lyme disease is a vector borne zoonotic disease that is usually caused by bacteria known as Borrelia burgdorferi sensu lato. A tick vector of the disease, Ixodes scapularis, spreads in different regions of North America and became a major cause of the upsurge of Lyme disease in the above mentioned region of America between 2004 and 2016 (Pitrak et al 2022). The disease shows the symptoms like arthritis in the beginning of the infection.…”

Section: Introductionmentioning

confidence: 99%

Lyme Disease: Etiology, Transmission, Impact and Control

2023

IJAB

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Lyme disease is an infection caused by bacteria known as Borrelia burgdorferi sensu lato, is the most widespread vector-borne disease in the United States, and transmitted to human beings through the bite of Ixodes tick. However, significant portion (10-30%) individuals may experience ancillary nonspecific symptoms that last months after the completion of therapy. The group of symptoms known as post-treatment Lyme disease syndrome (PTLDS), a form of the more general term "chronic Lyme disease," includes tiredness, cognitive impairment, and musculoskeletal discomfort. These symptoms are linked to disability and last longer than six months. Patients with nonspecific symptoms assumed to be caused by a supposed persistent Borrelia burgdorferi infection and may or may not exhibit signs of Lyme disease are referred to as having chronic Lyme disease. The diagnosis of PTLDS and chronic Lyme disease has become more and more important in immunologists' practices because it is difficult to diagnose. ELISA and western blot testing are useful in diagnosing Lyme disease. The cornerstone of care is still antibiotic therapy. This chapter reviews the evidence that supports current understanding of the life cycle, historical biogeography, and evolution of Ixodes spp., the ticks that carry the Lyme disease, as well as their methods of dispersal, and disease-transmission mechanisms, and the efficacy of vector control interventions.

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Diagnosis of Lyme Disease

Abstract: This JAMA Clinical Guidelines Synopsis summarizes the diagnosis portion of a 2020 practice guideline on Lyme disease.

Cited by 6 publications

References 8 publications

Facial Paralysis Due to Brazilian Lyme Disease: A Case Report and Literature Review

Facial Paralysis Due to Brazilian Lyme Disease: A Case Report and Literature Review

Prevention and Treatment of Lyme Disease

Lyme Disease: Etiology, Transmission, Impact and Control

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