Prevention and Treatment of Lyme Disease

Nguyen, Cynthia T; Cifu, Adam S.; Pitrak, David

doi:10.1001/jama.2021.25302

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…132 Recent guidelines recommend antibiotic prophylaxis with one dose of oral doxycycline within 72 hours of tick removal after a high-risk bite. 133…”

Section: Commentmentioning

confidence: 99%

“…The latest evidence-based guideline provides an extensive review and several other recommendations. 133,134 No difference in patient outcomes has been found in patients treated with oral doxycycline compared with IV ceftriaxone in acute neuroborreliosis. 135 A phase 3 clinical trial for a prophylactic Lyme disease vaccine is underway in North America and Europe.…”

Section: Key Pointsmentioning

confidence: 99%

“…Per the US Centers for Disease Control and Prevention, the benefit of prophylaxis may outweigh the risks when all of the following are present: the bite occurred in an area where ticks are likely to be infected, the tick was removed in the previous 72 hours, the tick was an Ixodes tick with an engorged body (with blood), and doxycycline is safe for the patient 132 . Recent guidelines recommend antibiotic prophylaxis with one dose of oral doxycycline within 72 hours of tick removal after a high-risk bite 133 …”

Section: Bacterial Infectionsmentioning

confidence: 99%

“…For acute neurologic manifestations of Lyme disease, a 14-day to 21-day course of IV ceftriaxone 2 g daily, cefotaxime, penicillin G, or oral doxycycline is recommended. The latest evidence-based guideline provides an extensive review and several other recommendations 133,134 . No difference in patient outcomes has been found in patients treated with oral doxycycline compared with IV ceftriaxone in acute neuroborreliosis 135 .…”

Section: Bacterial Infectionsmentioning

confidence: 99%

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Infectious Neuropathies

Boegle,

Narayanaswami

2023

CONTINUUM: Lifelong Learning in Neurology

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Objective This article discusses the clinical manifestations and management of infectious peripheral neuropathies. Latest Developments Several infectious etiologies of peripheral neuropathy are well-recognized and their treatments are firmly established. The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with several central and peripheral nervous system manifestations, including peripheral neuropathies. Additionally, some COVID-19 vaccines have been associated with Guillain-Barré syndrome. These disorders are an active area of surveillance and research. Recent evidence-based guidelines have provided updated recommendations for the diagnosis and treatment of Lyme disease. Essential Points Infectious agents of many types (primarily bacteria and viruses) can affect the peripheral nerves, resulting in various clinical syndromes such as mononeuropathy or mononeuropathy multiplex, distal symmetric polyneuropathy, radiculopathy, inflammatory demyelinating polyradiculoneuropathy, and motor neuronopathy. Knowledge of these infections and the spectrum of peripheral nervous system disorders associated with them is essential because many have curative treatments. Furthermore, understanding the neuropathic presentations of these disorders may assist in diagnosing the underlying infection.

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“…132 Recent guidelines recommend antibiotic prophylaxis with one dose of oral doxycycline within 72 hours of tick removal after a high-risk bite. 133…”

Section: Commentmentioning

confidence: 99%

Section: Key Pointsmentioning

confidence: 99%

Section: Bacterial Infectionsmentioning

confidence: 99%

Section: Bacterial Infectionsmentioning

confidence: 99%

See 2 more Smart Citations

Infectious Neuropathies

Boegle,

Narayanaswami

2023

CONTINUUM: Lifelong Learning in Neurology

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“…Activities like outdoor sports, gardening, forestry, hunting, and logging are significantly linked to an elevated risk of contracting tick-borne diseases [ 2 ]. Since there is currently no vaccine available for most of tick-borne diseases, intervention strategies primarily focus on controlling and minimizing tick exposure to manage the associated risks [ [3] , [4] , [5] ].…”

Section: Introductionmentioning

confidence: 99%