Diagnosis of Lactose Malabsorption

Gudmand-Høyer, E; Jarnum, S.

doi:10.1016/s0016-5085(68)80023-x

Cited by 10 publications

(4 citation statements)

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“…Because it is inconvenient to take small intestinal biopsies for lactase activity determinations, a lactose tolerance (loading) test was developed to verify hypolactasia or, in fact, the ability of the small intestinal mucosa to hydrolyse and absorb lactose (13,31,41,48,60,79,110). The terms lactose malabsorption and lactose maldigestion describe a poor lactose hydrolysing capacity which can be demonstrated, e.g.…”

Section: The Terminologymentioning

confidence: 99%

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Sahi

1994

Scandinavian Journal of Gastroenterology

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and Headquarters of the Frontier Guard, Helsinki, Finland Sahi T. Hypolactasia and lactase persistence. Historical review and the terminology. %and J Gastroenterol 19!44;29 Suppl202:1-6.Lactase (more precisely lactase-phlorizin hydrolase) is located in the brush border of the small intestinal enterocytes and is responsible for the hydrolysis of dietary lactose. The earliest studies on lactase activity in mammals were published around the turn of the century. In 1903, it was found that the dog had a very low lactase activity and therefore lactose remained unhydrolysed, causing diarrhoea. Human hypolactasia was demonstrated in 1%3, and it was soon found that it is very common, commoner than lactase persistence in most parts of the world. In 1973, adult-type hypolactasia was shown to be inherited by an autosomal recessive single gene. This article reviews the early expansion of the knowledge on lactase and hypolactasia as well as the correct terminology.(47) * Scand J Gastroenterol Downloaded from informahealthcare.com by Indiana University on 12/13/14For personal use only.

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Section: The Terminologymentioning

confidence: 99%

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Sahi

1994

Scandinavian Journal of Gastroenterology

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“…Blood glucose was determined regularly for two hours following the oral intake of lOOg lactose (Gudmand-H0yer and Jarnum, 1968). Clinical symptoms arising during the test were carefully registered.…”

Section: Lactose Tolerance Testmentioning

confidence: 99%

Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn's disease

Gudmand-Høyer¹,

Jarnum²

1970

Gut

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“…Examples of replacing diagnostic blood extraction with less invasive procedures are extensive. The original approach to assessing lactose maldigestion in association with lactose intolerance involved administering 50 to 100 g of lactose in water and drawing blood at intervals over 3 or more hours to measure the increase in circulating glucose [18,19]. With the advent of technology to quantify hydrogen (H 2 ) in expired air, a lactose maldigestion breath test was validated [20,21].…”

Section: Discussionmentioning

confidence: 99%

Correspondence of Hemoglobin Values Obtained by a Noninvasive, Cutaneous-Contact Method with Values Obtained by Conventional Methods from Whole Blood Samples in a Guatemalan Field Setting

Crowley¹,

Montenegro-Bethancourt²,

Arriaga³

et al. 2010

Food Nutr Bull

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Background. Anemia is a widespread public health issue, conventionally diagnosed by analyzing the hemoglobin concentration in whole blood samples. Aspects of safety, comfort, and cultural acceptability would be obviated if reliable, noninvasive anemia screening were available.Objective. To determine day-to-day variations within subjects in hemoglobin measurements and the correspondence of hemoglobin values obtained by a noninvasive, photometric, cutaneous-contact method with values obtained by conventional methods from blood samples. Methods. The hemoglobin level was determined in 40 pregnant women from the Guatemalan coastal plain (low values) and 40 men from the highlands (high values).Hemoglobin concentrations (g/dl) were measured in an automated cell counter and, in parallel, estimated with the use of the Rad-87™ Rainbow pulse CO-Oximeter placed over the nail bed of the ring finger.Results. The mean value for invasively determined hemoglobin was 13.5 g/dl, as compared with 12.2 and 12.1 g/dl for the noninvasive nail-bed estimate at 10 and 5 minutes, respectively. Measurements using the noninvasive technology were highly stable within days and from day to day. The noninvasive screening method showed satisfactory sensitivity and specificity at hemoglobin concentrations of < 12.0 g/dl (cutoff value for nonpregnant women) and < 13.0 g/dl (cutoff value for adult men). Diagnostic discrimination was poorer for the lower cutoff criteria; the anemia cutoff values were < 11.5 g/dl for school-age children and < 11.0 g/dl for pregnant women and children under 5 years of age.Conclusions. Noninvasive hemoglobin screening shows considerable promise, although improvement of sensitivity and specificity in the anemic range and determination periods of less than 10 minutes are desirable.

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Diagnosis of Lactose Malabsorption

Cited by 10 publications

References 0 publications

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Hypolactasia and Lactase Persistence Historical Review and the Terminology

Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn's disease

Correspondence of Hemoglobin Values Obtained by a Noninvasive, Cutaneous-Contact Method with Values Obtained by Conventional Methods from Whole Blood Samples in a Guatemalan Field Setting

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