Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn's disease

Gudmand-Høyer, E; Jarnum, S.

doi:10.1136/gut.11.4.338

Cited by 35 publications

(17 citation statements)

References 18 publications

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“…The incidence of milk intolerance is comparable with the incidence of lactase deficiency described for a Caucasian population by Newcomer and McGill (1967). It is not always recognized by the patient and experience in this study suggests, as in the study of Gudmand-H0yer and Jarnum (1970), that trial of a milk-free diet is worthwhile in patients who complain of watery stools after ileorectal anastomosis.…”

Section: Discussionsupporting

confidence: 63%

Comparison of bowel function after ileorectal anastomosis for ulcerative colitis and colonic polyposis.

Newton¹,

Baker²

1975

Gut

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Section: Discussionsupporting

confidence: 63%

Comparison of bowel function after ileorectal anastomosis for ulcerative colitis and colonic polyposis.

Newton¹,

Baker²

1975

Gut

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“…In a double-blind crossover study of 39 UC patients, BT outcomes were similar to Mexican population rates [46 % vs about 50 –70 %] [ 43 ]. In 2 studies from Denmark, (national LM prevalence, 5–6 %), performance of an LTT showed no difference from expected rates [6 % CD, 9 % UC] [ 44 , 45 ]. However one reported higher LM rates with activity of IBD [ 44 ], while the other found no relationship other than ethnic distribution in UC patients [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis of lactose digestion, its impact on intolerance and nutritional effects of dairy food restriction in inflammatory bowel diseases

Szilagyi

Galiatsatos

Xue

2015

Nutr J

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BackgroundRelationships between inflammatory bowel disease and lactose containing foods remain controversial and poorly defined regarding symptoms, nutritional outcomes, and epidemiologic associations for lactose maldigestion.MethodsA literature review was performed using Pub Med, Cochrane library and individual references, to extract data on lactose maldigestion prevalence in inflammatory bowel diseases. A meta-analysis was done using selected articles, to determine odds ratios of maldigestion. Information was collected about symptoms, impact on pattern of dairy food consumption, as well as the effects of dairy foods on the course of inflammatory bowel diseases.ResultsA total of 1022 articles were evaluated, 35 articles were retained and 5 studies were added from review articles. Of these 17 were included in meta-analysis which showed overall increased lactose maldigestion in both diseases. However increased risk on sub analysis was only found in Crohn’s in patients with small bowel involvement. Nine additional studies were reviewed for symptoms, with variable outcomes due to confounding between lactose intolerance and lactose maldigestion. Fourteen studies were evaluated for dairy food effects. There was a suggestion that dairy foods may protect against inflammatory bowel disease. Nutritional consequences of dairy restrictions might impact adversely on bone and colonic complications.ConclusionsLactose maldigestion in inflammatory bowel disease is dependent on ethnic makeup of the population and usually not disease. No bias of increased disease prevalence was noted between lactase genotypes. Intolerance symptoms depend on several parameters besides lactose maldigestion. Dairy foods may decrease risks of inflammatory bowel disease. Dairy restrictions may adversely affect disease outcome.

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“…Although the true incidence of these entities is still debatable, the benefits of a milk-free diet appear to be convincing [8,16,17,24]. While the exact mechanism is still unknown, we can at least suggest that the lactase deficiency is an epiphenomenon in which some dietary regimens can be attempted with successful symptomatic improvement.…”

Section: Discussionmentioning

confidence: 89%

Association of lymphocytic colitis and lactase deficiency in pediatric population

Sun

Parashette

et al. 2015

Pathology - Research and Practice

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Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn's disease

Cited by 35 publications

References 18 publications

Comparison of bowel function after ileorectal anastomosis for ulcerative colitis and colonic polyposis.

Comparison of bowel function after ileorectal anastomosis for ulcerative colitis and colonic polyposis.

Systematic review and meta-analysis of lactose digestion, its impact on intolerance and nutritional effects of dairy food restriction in inflammatory bowel diseases

Association of lymphocytic colitis and lactase deficiency in pediatric population

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