Diagnosis of Herpes Simplex Encephalitis by ELISA Using Antipeptide Antibodies Against Type-Common Epitopes of Glycoprotein B of Herpes Simplex Viruses

Bhullar, Shradha S.; Chandak, Nitin H.; Baheti, Neeraj N; Purohit, Hemant J.; Taori, Girdhar M.; Daginawala, Hatim F.; Kashyap, Rajpal S.

doi:10.1080/15321819.2015.1100119

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…Peptide Abs are usually of high specificity and affinity, and have the advantage that the antigenic target is already well-defined [94,128,129]. Based on this knowledge, peptide Abs have become a powerful tool, not only for immunological research approaches but in clinical diagnostics as well [66,67,128,130,131].…”

Section: Discovery and Propertiesmentioning

confidence: 99%

Peptides, Antibodies, Peptide Antibodies and More

Trier

Hansen

Houen

2019

IJMS

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The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and broad spectrum of use as illustrated by numerous applications of peptide antibodies. In recent years, due to the inherent limitations such as size and physical properties of antibodies, it has been attempted to generate new molecular compounds with equally high specificity and affinity, albeit with relatively low success. Based on this, peptides, antibodies, and peptide antibodies have established their importance and remain crucial reagents in molecular biology.

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Section: Discovery and Propertiesmentioning

confidence: 99%

Peptides, Antibodies, Peptide Antibodies and More

Trier

Hansen

Houen

2019

IJMS

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“…HSV antibody in CSF is not helpful for early diagnosis, but it helps in retrospective HSE identification. HSV viral culture in CSF is rarely positive [[38], [39], [40]]. The neuroimaging of choice for HSE diagnosis is MRI brain which is more sensitive and specific than CT scan.…”

Section: Diagnosismentioning

confidence: 99%

Approach to recurrent Herpes Simplex Encephalitis in children

Alsweed

Alsuhibani

Casanova

et al. 2018

International Journal of Pediatrics and Adolescent Medicine

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Herpes Simplex Encephalitis (HSE) is one of the commonest viral encephalitis and its recurrence is being increasingly reported were HSE relapse rate came up to 5%. Both herpes simplex virus (HSV) types can lead to encephalitis and it was established that HSV-1 is capable of nervous system invasion, latency, and recurrence. The recurrence of HSE used to be attributed to immunological compromise, but reports show many cases have no obvious immune system impairment. Further investigations revealed genetic predispositions to HSV infection that would explain the host vulnerability to its recurrence. In this review, we discuss the gene mutations that may predispose to recurrent HSE and the importance of early diagnosis and treatment.

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“…The CSF viral load predicts an uncertain outcome, and there is no consensus between quantitation of HSV DNA in CSF and severity of clinical disease and prognosis [ 196 , 197 ]. Serological testing has also been used in diagnosis of HSV in CNS [ 198 ].…”

Section: Viruses Commonly Associated With Cns Infection In Brazilmentioning

confidence: 99%

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Sousa

Santos

Paula

et al. 2021

Viruses

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Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations have been neglected. Typically, herpes simplex virus 1 and 2, varicella-zoster, and enterovirus are responsible for a high number of cases in immunocompetent hosts, whereas other herpesviruses (for example, cytomegalovirus) are the most common in immunocompromised individuals. Arboviruses have also been associated with outbreaks with a high burden of neurological disorders, such as the Zika virus epidemic in Brazil. There is a current lack of understanding in Brazil about the most common viruses involved in CNS infections. In this review, we briefly summarize the most recent studies and findings associated with the CNS, in addition to epidemiological data that provide extensive information on the circulation and diversity of the most common neuro-invasive viruses in Brazil. We also highlight important aspects of the prion-associated diseases. This review provides readers with better knowledge of virus-associated CNS infections. A deeper understanding of these infections will support the improvement of the current surveillance strategies to allow the timely monitoring of the emergence/re-emergence of neurotropic viruses.

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Diagnosis of Herpes Simplex Encephalitis by ELISA Using Antipeptide Antibodies Against Type-Common Epitopes of Glycoprotein B of Herpes Simplex Viruses

Cited by 6 publications

References 16 publications

Peptides, Antibodies, Peptide Antibodies and More

Peptides, Antibodies, Peptide Antibodies and More

Approach to recurrent Herpes Simplex Encephalitis in children

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

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