Approach to recurrent Herpes Simplex Encephalitis in children

Alsweed, Abdulrahman; Alsuhibani, Mohammed; Casanova, Jean‐Laurent; Al-Hajjar, Sami

doi:10.1016/j.ijpam.2018.05.004

Cited by 28 publications

(26 citation statements)

References 43 publications

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“…I believe that patients who have nearly continual recurrences, however, are worth considering. Patients with encephalitis caused by HSV also do not have NKD in my experience and it is now known that these cases result from a variety of defects that have little to do with NK cells and instead result from an impact on important components of CNS innate immunity [54].…”

Section: What Is Not Nkdmentioning

confidence: 89%

How I Manage Natural Killer Cell Deficiency

Orange

2019

J Clin Immunol

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Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient's clinical immunodeficiency. This is distinct from a much larger group of PIDs that include an NK cell abnormality as a minor component of the immunodeficiency. Patients with NKD most frequently have atypical consequences of herpesviral infections. There are now 6 genes that have been ascribed to causing NKD, some exclusively and others that also cause other known immunodeficiencies. This list has grown in recent years and as such the mechanistic and molecular clarity around what defines an NKD is an emerging and important field of research. Continued increased clarity will allow for more rational approaches to the patients themselves from a therapeutic standpoint. Having evaluated numerous individuals for NKD, I share my perspective on approaching the diagnosis and managing these patients.

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Section: What Is Not Nkdmentioning

confidence: 89%

How I Manage Natural Killer Cell Deficiency

Orange

2019

J Clin Immunol

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“…Herpes simplex virus is the most common cause of viral encephalitis in developed countries. 2 The annual incidence of HSV-1 encephalitis in the United States is estimated to be 4,000 cases, with one-third of these cases affecting children. 2 .…”

Section: Discussionmentioning

confidence: 99%

“…2 The annual incidence of HSV-1 encephalitis in the United States is estimated to be 4,000 cases, with one-third of these cases affecting children. 2 . As per IDSA guidelines, adequate treatment of HSE requires a three-week course of acyclovir.…”

Section: Discussionmentioning

confidence: 99%

“…1 Potential triggers of reactivation include immunosuppression, fever, and direct insult. 1,2,3 HSV reactivation may cause recurrence of an infectious process, herpes simplex encephalitis (HSE), or recurrence of a relatively benign condition, Mollaret's meningitis. Here we report the case of a patient with intractable epilepsy following a febrile illness at age two thought to be secondary to HSV.…”

Section: Introductionmentioning

confidence: 99%

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Child Neurology: Intractable Epilepsy and Transient Deficits in a Patient With a History of Herpes Simplex Virus Encephalitis

et al. 2021

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“…[1–3] It mainly manifests with fever, convulsions, confusion, focal neurologic signs and progressive deterioration. [4–6] Normally, it is diagnosed according to the results of herpes simplex virus detection in the cerebrospinal fluid. [7] It is estimated that the incidence of HSE ranges from 1 to 2 cases per 500,000 population each year.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of acyclovir for herpes simplex encephalitis

Wang¹,

Ji²

2019

Medicine

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Background: Clinical researches indicate that acyclovir can be used to herpes simplex encephalitis (HSE). However, no systematic review has explored its efficacy for the treatment of HSE. Therefore, this study systematically will investigate the efficacy and safety of acyclovir for patients with HSE. Methods: We will search the following databases from inceptions to March 1, 2019 without any language restrictions: Cochrane Library, Embase, MEDICINE, PsycINFO, Web of Science, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. This study will include randomized controlled trials that assess the efficacy and safety of acyclovir for patients with HSE. Two authors will independently carry out the study selection, data extraction, and risk of bias assessment. Cochrane risk of bias tool will be used to assess the risk of bias assessment. Results: This study will systematically assess the efficacy and safety of acyclovir for HSE. The primary outcome is mortality rate, which is measured by Glasgow coma score, or other instruments. The secondary outcomes include quality of life, as assessed by 36-Item Short Form Health Survey or relevant scales; overall survival, the number of patient who died; the number of patient who had severe sequelae, and adverse events. Conclusions: The findings of this study may provide the existing evidence on the efficacy and safety of acyclovir for HSE. PROSPERO registration number: PROSPERO CRD42019125999.

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Approach to recurrent Herpes Simplex Encephalitis in children

Cited by 28 publications

References 43 publications

How I Manage Natural Killer Cell Deficiency

How I Manage Natural Killer Cell Deficiency

Child Neurology: Intractable Epilepsy and Transient Deficits in a Patient With a History of Herpes Simplex Virus Encephalitis

Efficacy of acyclovir for herpes simplex encephalitis

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