Diagnosis of Helicobacter Pylori Infection: Noninvasive Methods Compared To Invasive Methods and Evaluation of Two New Tests

Monteiro, Lurdes; Mascarel, A. De; Sarrasqueta, Anne Marie; Bergey, Bernard; Barberis, Christophe; Talby, Patrice; Roux, Dominique; Shouler, Laurent; Goldfain, D; Lamouliatte, H; Mégraudgraud, Francis

doi:10.1111/j.1572-0241.2001.03518.x

Cited by 148 publications

(74 citation statements)

References 26 publications

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“…It has been reported to be 82-90% sensitive and 99-100% specifi c to diagnose HP infection [12,[14][15][16]. Our fi nding of an 89.8% sensitivity and a 100% specifi city is in accordance with these fi gures.…”

Section: Discussionsupporting

confidence: 90%

“…It is well known that in daily practice, a combination of tests is recommended and the simultaneous positivity of at least two different tests may therefore be considered diagnostic for HP presence and therefore a gold standard for the detection of HP infection [11,12]. Various invasive and noninvasive methods had previously been compared for the diagnosis of HP infection, but, to our knowledge, ours is the fi rst study to compare Heliprobe UBT with RUT, PCR, and histopathological examination [12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

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Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

et al. 2008

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

et al. 2008

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“…Patients were evaluated at least eight weeks after the treatment to assess the success of treatment by control endoscopy, urea breath test or HP stool antigen test. Both of these tests have been reported to have similar results with sensitivity and specificity rates over 90% (50). Therefore, these differences did not influence our results.…”

Section: Discussionsupporting

confidence: 68%

First-line therapy in Helicobacter pylori eradication therapy: experience of a surgical clinic

Özbalcı

Yürüker

Tarim

et al. 2014

UCD

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Objective: Helicobacter pylori (HP) is the world's most common infectious agent. Despite conventional therapy consisting of proton pump inhibitor (PPI), amoxicillin (AMO) and clarithromycin (CLA), approximately half of the patients remain infected. We compared the PPI-based triple therapy with quadruple treatment (BPMT) including bismuth citrate (BS), PPI, metronidazole (MET) and tetracycline (TET). Material and Methods:Forty-three patients who used triple therapy (LAC) consisting of lansoprazole (L), AMO and CLA and 42 patients who used quadruple therapy (BPMT) for 14 days between May 2008 and November 2013 were included in the study. The LAC group included patients who received 30 mg L 2x1, 1000 mg AMO 2x1, and 500 mg CLA 2x1 for 14 days, whereas the BPMT group was designed from patients who received 600 mg BS 2x1, 40 mg omeprazole (O) 2x1 or 30 mg L 2x1, 500 mg MET 3x1 and 500 mg TET 4x1.Results: Demographic characteristics and endoscopic findings were similar in both groups. The eradication rate was 53.4% in the LAC group and 78.5% in the BPMT group (p<0.05). Compliance problems and side effects were significantly higher in the BPMT group as compared to the LAC group (p<0.05). Conclusion:Due to high antibiotic resistance in Turkey, the efficacy of LAC treatment has reduced. The BPMT protocol should be kept in mind in the first line of treatment, since it provides a higher eradication rate.

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“…The subjects were screened for H. pylori infection using the 13 C-urea breath test. As a screening test, the 13 C-urea breath test has high sensitivity and specificity [13][14][15][16][17]. A written, informed consent was obtained from all the volunteers prior to the isotopic studies.…”

Section: Subjectsmentioning

confidence: 99%

Effect of Helicobacter pylori Infection on Iron Absorption in Asymptomatic Adults Consuming Wheat Flour Fortified with Iron and Zinc

Romaña

Pizarro

Diazgranados

et al. 2011

Biol Trace Elem Res

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Helicobacter pylori infection could impair iron absorption from fortified products. The objective of the study was to determine the effect of H. pylori infection on iron absorption from asymptomatic adults consuming wheat flour fortified with iron and zinc. The (13)C urea breath test was used to assess H. pylori infection. Twenty-four H. pylori-positive and 26 H. pylori-negative volunteers completed the study. On day 1, the subjects were randomized to receive for breakfast bread fortified with either ferrous sulfate and zinc sulfate or ferrous fumarate and zinc oxide. Bread fortified with ferrous sulfate was labeled with (59)Fe as sulfate, and bread fortified with ferrous fumarate was labeled with (55)Fe as fumarate. On day 3, they received the other type of bread, with the respective tracers. On days 18-23, a proton pump inhibitor was administered to all subjects. On day 24, all subjects received bread fortified with ferrous fumarate and zinc oxide labeled with (55)Fe as fumarate. H. pylori prevalence was 77.6%. The geometric mean (±1 SD) of iron absorption was significantly higher for ferrous sulfate than fumarate (6.9 ± 2.9% vs. 0.5 ± 3.5%, p < 0.001). The H. pylori-negative subjects absorbed significantly more iron from bread fortified with either ferrous sulfate (10.5 ± 3.1% vs. 4.4 ± 2.2%, p < 0.001) or ferrous fumarate (0.6 ± 3.9% vs. 0.4 ± 3.1%, p < 0.001). Iron absorption was not significantly different between groups after administration of a proton pump inhibitor (0.3 ± 3.3% vs. 0.3 ± 2.7%, p = 0.11). H. pylori infection has a negative effect on iron absorption in asymptomatic adults consuming iron- and zinc-fortified wheat flour.

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Diagnosis of Helicobacter Pylori Infection: Noninvasive Methods Compared To Invasive Methods and Evaluation of Two New Tests

Cited by 148 publications

References 26 publications

Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

First-line therapy in Helicobacter pylori eradication therapy: experience of a surgical clinic

Effect of Helicobacter pylori Infection on Iron Absorption in Asymptomatic Adults Consuming Wheat Flour Fortified with Iron and Zinc

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