Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

Özdemir, Elif; Karabacak, Neşe İlgin; Değertekın, Bülent; Çırak, Meltem Yalınay; Dursun, Ayşe; Engin, Evren Doruk; Ünal, Selahattin; Ünlü, Mustafa

doi:10.1007/s12149-008-0168-6

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…They found that Heliprobe had 92% sensitivity, 100% specificity, 100% PPV, 84% NPV, and 94% accuracy [19]. Our results are also in accordance with Ozdemir et al's results for Heliprobe performance (96.6% sensitivity, 100% specificity, 93.7% PPV, 100% NPV, and 97.7% accuracy), although their H. pylori positive gold standard was defined as “positivity of any two of the three following tests (RUT, PCR, and histopathology)” [20]. …”

Section: Discussionsupporting

confidence: 90%

Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Ghanaei

Joukar

2011

Gastroenterology Research and Practice

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Background. We encountered repeatedly, in our clinical practice, discordant results between UBT and histopathology about H. pylori infection. Goal. To study the diagnostic accuracy of Heliprobe 14C-urea breath test (14C-UBT) for detection of H. pylori infection in an Iranian population. Study. We enrolled 125 dyspeptic patients in our study. All of them underwent gastroscopy, and four gastric biopsies (three from the antrum and one from the corpus) were obtained. One of the antral biopsies was utilized for a rapid urease test (RUT), and three others were evaluated under microscopic examination. Sera from all patients were investigated for the presence of H. pylori IgG antibodies. The 14C-UBT was performed on all subjects using Heliprobe kit, and results were analyzed against the following gold standard (GS): H. pylori infection considered positive when any two of three diagnostic methods (histopathology, RUT, serology) are positive. Results. According to data analysis, the Heliprobe 14C-UBT had 94% sensitivity, 100% specificity, 93% negative predictive value (NPV), 100% positive predictive value (PPV), and 97% accuracy, compared with GS. Conclusion. The Heliprobe 14C-UBT is an easy-to-perform, rapid-response, and accurate test for H. pylori diagnosis, suitable for office use.

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Section: Discussionsupporting

confidence: 90%

Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Ghanaei

Joukar

2011

Gastroenterology Research and Practice

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“…The 14 C-UBT (Heliprobe system) is an easy and rapid way with sensitivity of 94% and specificity of 100% for diagnosis of H. pylori infection in patients with dyspeptic complaints 2223…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

et al. 2013

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Background:Helicobacter pylori infection is a basic risk factor for chronic gastritis, and gastric carcinoma. Based on some studies, the reason is binding of H. pylori to H and Leb antigens in gastric mucosa. However, some other findings have not determined any association between the infection and these antigens. Because of this controversy and the fact that H. pylori infection and gastric adenocarcinoma are common diseases in Iran, the assessment of the association of H. pylori infection with these blood groups could be valuable.Materials and Methods:In a cross sectional study on 135 adult dyspeptic patients in Mashhad, Iran, from 2009 to 2010, H. pylori infection was evaluated by using the Heliprobe 14C-urea breath test and the ABO and Lewis blood group antigens were determined by the tube method. Association between the Lewis and ABO phenotypes with H. pylori infection were analysed by Fisher's exact test. A P ≤ 0.05 was considered to be significant.Results:68 (50.4%) patients were positive for H. pylori infection. The frequencies of the ABO, Lewis and secretion phenotypes were not significant in the infected and non-infected patients. We also did not find a significant association between Lea and Leb antigens and this infection.Conclusion:We could not establish a significant association between the Lewis, ABO and secretion phenotypes with H. pylori infection. Diversity of sequences of blood group antigen b-binding adhesion (babA gene) of H. pylori may be a reason why our findings are different from other studies in other geographic areas.

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“…C14 UBT is a reliable and noninvasive technique for the diagnosis of HP infection. The sensitivity of the UBT was 96.6%-100% and its specificity was 76%-100% in different studies (20,23). However in a study from Turkey, the prevalence of HP infection was detected as 68% using the C14 UBT in 1680 patients with variable gastrointestinal complaints (24).…”

Section: Discussionmentioning

confidence: 99%

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Rifaioğlu¹,

Aydogan²,

Şen³

et al. 2014

Turk J Med Sci

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IntroductionVitiligo is an acquired depigmenting skin disorder. It occurs clinically by the appearance of well-circumscribed, asymptomatic, white macules following the loss of functional melanocytes in the epidermis (1). The prevalence rate of vitiligo ranges from 0.06% to 2.28% in the population (2). The main etiopathogenesis of vitiligo is multifactorial. According to various pathophysiological theories, it may be associated with autoimmunity, neurogenic dysregulation, autocytotoxicity, biochemical dysregulation, oxidative stress, and weak melanocyte viability (1,(3)(4)(5)(6). Several potentially environmental factors such as infectious agents appear to be related with vitiligo (7-9).Helicobacter pylori (HP) is a major health problem affecting about 50% of the world population (10). Gastric ulceration and carcinogenesis are associated with HP infection (11). HP infection has been linked to various autoimmune dermatological diseases, such as alopecia areata, Behçet's disease, chronic urticaria, pruritus, psoriasis, and rosacea (12-17). The frequency of HP has not been studied in patients with vitiligo. Noninvasive tests such as the carbon 13 or carbon 14 (C14) urea breath test (UBT), stool antigen tests, and serology are used to detect HP infection (18). In this study, we used the C14 UBT to detect the frequency of HP infection in patients with vitiligo. Materials and methods Patient and control groupsWith the approval of the local ethics committee, a prospective study was conducted in our dermatology department clinic. The study comprised 34 patients with vitiligo and 30 age-and sex-matched healthy controls. The patients with vitiligo were newly diagnosed and older than 16 years. The patients with gastrointestinal symptoms or those who had received eradication therapy for HP earlier were excluded from the study. Other exclusion criteria were age under 16 years, pregnancy or lactation, and the use of antibiotics, proton pump inhibitors, or H2 blockers in the 40, 7, and 14 days, respectively, leading up to sample collection. According to the working clinical classification, vitiligo was classified as vitiligo vulgaris, acrofacial, focal, segmental, universal, or mucosal (16).Background/aim: Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea breath test (UBT) in patients with vitiligo. Materials and methods:This study included 34 patients (18 males and 16 females) with vitiligo and 30 age-and sex-matched healthy controls. HP infection was diagnosed using the C14 UBT (Heliprobe). Statistical analysis was performed using SPSS 19. Results:The frequency of HP infection was 64.7% in the patient group and 33.3% in the control group according to the C14 UBT (chisquare test, P = 0.012). HP infection frequ...

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Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

Abstract: Using a combination of invasive diagnostic tests as the gold standard, Heliprobe UBT was found to be highly sensitive and specific for the diagnosis of HP infection in patients with dyspeptic complaints.

Cited by 15 publications

References 28 publications

Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

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Could the simplified 14C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?

Abstract: Using a combination of invasive diagnostic tests as the gold standard, Heliprobe UBT was found to be highly sensitive and specific for the diagnosis of HP infection in patients with dyspeptic complaints.

Cited by 15 publications

References 28 publications

Clinical Validation of an Office-Based14C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Clinical Validation of an Office-Based14C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

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Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients