Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Abstract

Background. We encountered repeatedly, in our clinical practice, discordant results between UBT and histopathology about H. pylori infection. Goal. To study the diagnostic accuracy of Heliprobe 14C-urea breath test (14C-UBT) for detection of H. pylori infection in an Iranian population. Study. We enrolled 125 dyspeptic patients in our study. All of them underwent gastroscopy, and four gastric biopsies (three from the antrum and one from the corpus) were obtained. One of the antral biopsies was utilized for a rapid urease test (RUT), and three others were evaluated under microscopic examination. Sera from all patients were investigated for the presence of H. pylori IgG antibodies. The 14C-UBT was performed on all subjects using Heliprobe kit, and results were analyzed against the following gold standard (GS): H. pylori infection considered positive when any two of three diagnostic methods (histopathology, RUT, serology) are positive. Results. According to data analysis, the Heliprobe 14C-UBT had 94% sensitivity, 100% specificity, 93% negative predictive value (NPV), 100% positive predictive value (PPV), and 97% accuracy, compared with GS. Conclusion. The Heliprobe 14C-UBT is an easy-to-perform, rapid-response, and accurate test for H. pylori diagnosis, suitable for office use.

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

“…The 14 C-UBT (Heliprobe system) is an easy and rapid way with sensitivity of 94% and specificity of 100% for diagnosis of H. pylori infection in patients with dyspeptic complaints 2223…”

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

“…In conclusion, this study recommended using SAT, rather than UBT, for the diagnosis of H. pylori infection in untreated patients, while pointing the need for follow-up studies. However, an additional Iranian study (n = 125) by Mansour-Ghanaei et al found high specificity (100%) and sensitivity (94%) for UBT using radioactive 14 C-urea [86].…”

Helicobacter Pylori Infection in Dyspeptic Patients in Industrial Belt in Jharkhand

“…Different studies from India show prevalence rate around 80% whereas in Bangladesh it ranges from 50% to >90%, in Japan 70%, in Africa 70-90%, in German 48.8%, in Switzerland 26.6% and in North America 7.1 to 30%. 12 From the above observation, it is clear that H. pylori is more prevalent in LMICs than the developed countries. Even Tam and our study was done in an industrial belt, which is relatively developed compared to the rural areas, our hick prevalence maybe due to lack of personal hygiene and health education.…”