Helicobacter Pylori Infection in Dyspeptic Patients in Industrial Belt in Jharkhand

Abstract

BACKGROUND The present study is done to study different aspects of Helicobacter pylori such as its prevalence, association with upper gastrointestinal pathology, diagnosis and treatment outcome. Gastric antral biopsy and serology for Helicobacter pylori was done for all dyspeptic patients. Histopathology, Gram stain and biopsy urease test was done from the gastric biopsy specimen. The prevalence of Helicobacter pylori infection was 58.8%. The sensitivity, specificity, positive and negative predictive value for histopathology was 96.9%, 100%, 100% and 95.8%, respectively; for biopsy urease, the values were test 80.4%, 100%, 100% and 78.2%, respectively; for Gram stain, the values were 85.6%, 97.1%, 97.6% and 82.5%, respectively; and for serology, the values were 94.8%, 77.9%, 86% and 91.4%, respectively. Mostly peptic ulcer and duodenitis cases followed by chronic active gastritis were associated with Helicobacter pylori infection. Repeat biopsy revealed eradication of Helicobacter pylori in 90.7% cases. In dyspeptic patients, endoscopic biopsy not only detects Helicobacter pylori infection, but also reveals different gastric pathologies.