Diagnosis of Helicobacter pylori infection with a stool assay: is it useful after eradication treatment?

Archimandritis, Athanasios; Giontzis, Apostolos; Kourtesas, Dimitris; Tzivras, Michalis; Smilakou, Stavroula; Davaris, Panagiotis

doi:10.1016/s0002-9270(01)02285-7

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Eighty‐nine studies, including 10,858 patients, fulfilled the inclusion criteria and evaluated the accuracy of the stool antigen test for the diagnosis of H. pylori in untreated patients (Table 1) [14–95]. Some of the studies reviewed included, in the same protocol, patients before and after therapy, without separating them depending on the time at which the H. pylori stool antigen test was performed, thus preventing us from calculating the true diagnostic accuracy in each circumstance [96–100].…”

Section: Resultsmentioning

confidence: 99%

Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: a Systematic Review

Gisbert¹,

Jm²

2004

Helicobacter

183

140

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Our aim was to review systematically the diagnostic accuracy of the Helicobacter pylori stool antigen test. Bibliographical searches were performed in several electronic databases and abstracts from congresses up to May 2003. Eighty-nine studies (10,858 patients) evaluated the stool antigen test in untreated patients. Mean sensitivity, specificity, positive predictive value and negative predictive value were 91%, 93%, 92% and 87%, respectively. Analysis of the eight studies (1399 patients) in which pretreatment evaluation of the monoclonal stool antigen test was performed showed better (p < .001) results (96%, 97%, 96% and 97%, respectively), with a clearer distinction between positive and negative results. Thirty-nine studies (3147 patients) evaluated the stool antigen test for the confirmation of H. pylori eradication 4-8 weeks after therapy, with accuracies of 86%, 92%, 76% and 93% for mean sensitivity, specificity, positive predictive value and negative predictive value, respectively. Results were similar when a gold standard based on at least two methods was used. Relatively low accuracy was reported in some posttreatment studies with the polyclonal stool antigen test. However, excellent results (p < .001) were achieved in all the six studies evaluating the monoclonal stool antigen test 4-8 weeks posttreatment. Results evaluating the stool antigen test < 4 weeks posttreatment are contradictory. Proton-pump inhibitors seem to affect the accuracy of the stool antigen test. Sensitivity and/or specificity in patients with gastrointestinal bleeding may be suboptimal. The stool antigen test performs well in children. Finally, the stool antigen test seems to be a cost-effective method.

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Section: Resultsmentioning

confidence: 99%

Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: a Systematic Review

Gisbert¹,

Jm²

2004

Helicobacter

183

140

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“…The latter was based on a mix of monoclonal antibodies that might ensure greater reproducibility of the test results. Preliminary results of this test have been excellent [13–16].…”

Section: Discussionmentioning

confidence: 99%

“…This test is based on the use of polyclonal antibodies and intertest variability has been found which was attributed to the different antigenic compositions of the test series used [12]. After this, a new enzyme immunoassay for detecting H. pylori antigens in stools that was based on a mix of monoclonal antibodies (FemtoLab H. pylori , Connex, Martinsried, Germany) was put on the market and preliminary results have been excellent [13–16].…”

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confidence: 99%

Comparison of two Different Stool Antigen Tests for the Primary Diagnosis of Helicobacter pylori Infection in Turkish Patients with Dyspepsia

Erzın¹,

Altun²,

Dobrucalı³

et al. 2004

Helicobacter

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Non-invasive diagnostic tests forHelicobacter pyloriinfection

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Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

153

130

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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Diagnosis of Helicobacter pylori infection with a stool assay: is it useful after eradication treatment?

Cited by 3 publications

References 7 publications

Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: a Systematic Review

Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: a Systematic Review

Comparison of two Different Stool Antigen Tests for the Primary Diagnosis of Helicobacter pylori Infection in Turkish Patients with Dyspepsia

Non-invasive diagnostic tests forHelicobacter pyloriinfection

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