Stool Antigen Test for the Diagnosis of <i>Helicobacter pylori</i> Infection: a Systematic Review

Gisbert, Javier P.; Jm, Pajares García

doi:10.1111/j.1083-4389.2004.00235.x

Cited by 183 publications

(162 citation statements)

References 135 publications

(204 reference statements)

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…Similar results were found in a comparably designed study involving 272 infected patients (sensitivity 94%, specificity 92%) [78]. This test has been extensively evaluated by several groups [79][80][81].…”

Section: Stool Antigen Assaysupporting

confidence: 74%

An update of laboratory diagnosis of Helicobacter pylori in the Kingdom of Saudi Arabia

Somily

Morshed

2015

J Infect Dev Ctries

View full text Add to dashboard Cite

Helicobacter pylori is a micro-aerophilic, slow-growing, Gram-negative spiral bacterium that colonizes the mucous lining of the human stomach. Infection with this bacterium has been identified as a cause of gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue lymphoma. Globally, the prevalence of H. pylori-related infection is high compared to any other infectious diseases, and the rate of prevalence much higher in developing countries than in developed nations. This review article aims to describe the trend of H. pylori-related works in the Kingdom of Saudi Arabia (KSA) and the use of various laboratory tests for the diagnosis of H. pylori-related infections in adults and children. Therefore, published literature was referenced in the explanation and discussion of the different methods used to diagnose H. pylori-related disease, including papers published in the KSA and other Middle Eastern countries. The PubMed (http://www.ncbi.nlm.nih.gov/pubmed?cmd=search) search engine was used extensively. Culture and histopathology tests have been employed widely to detect this pathogen at the early stage. However, over the years, an array of tests including the rapid urease test, serology, the urea breath test, the fecal antigen test, and molecular testing have been developed to diagnose and better manage H. pylori-associated diseases since the discovery of this novel pathogen.

show abstract

Section: Stool Antigen Assaysupporting

confidence: 74%

An update of laboratory diagnosis of Helicobacter pylori in the Kingdom of Saudi Arabia

Somily

Morshed

2015

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Some studies indicate that stool antigen tests are more sensitive and specific for current H. pylori infection, especially in children. 32 Finally, the number of subjects recruited was significantly larger than the number with complete data because of the logistical challenges of data collection at a mobile clinic ( Figure 1 ). As a result, we cannot make wider conclusions about the prevalence of anemia in the Central Plateau of Haiti or the causes of anemia.…”

Section: Discussionmentioning

confidence: 99%

Anemia and Helicobacter pylori Seroreactivity in a Rural Haitian Population

Shak¹,

Sodikoff²,

Speckman³

et al. 2011

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Anemia is a significant health concern worldwide and can be the result of nutritional, environmental, social, and infectious etiologies. We estimated the prevalence of anemia in 336 pre-school children and 132 adults in the rural Central Plateau of Haiti and assessed associations with age, sex, household size, water source, sanitation, and Helicobacter pylori seroreactivity using logistic regression analysis; 80.1% (269/336) of children and 63.6% (84/132) of adults were anemic. Among children, younger age was associated with increased prevalence of anemia (adjusted odds ratio [aOR] = 4.1, 95% confidence interval [CI] = 1.5–11.1 for children 6–11 months compared with children 48–59 months). Among adults, 50.8% were H. pylori-seropositive, and seropositivity was inversely associated with anemia (aOR = 0.4, 95% CI = 0.2–0.9). Anemia prevalence in this region of Haiti is very high and not attributable to sanitary conditions or a high prevalence of H. pylori infection.

show abstract

“…Bunun üzerine geliştirilen monoklonal antikor temelli ELISA testlerinin tedavi öncesi duyarlılık ve özgüllüklerinin, Gisbert ve ark. tarafından yapılan iki ayrı derlemede ortalama olarak sırasıyla %94-96 ve %97 olduğu ve poliklonal antikor içeren ELISA testlerine göre daha yüksek olduğu bildirilmiştir [30,31].…”

Section: Bulgularunclassified

Evaluation of Helicobacter pylori antigen positivity in stool samples of patients with dyspeptic complaints in a tertiary care hospital

Selek¹

2013

DicleMedj

View full text Add to dashboard Cite

Objective: Helicobacter pylori is a microorganism associated with gastritis, peptic ulcer disease and gastric cancer. We aimed to figure out the positivity rate in stool samples of outpatients with dyspeptic complaints visiting gastroenterology department and to evaluate its relation with age, gender and seasonal changes.Methods: Between January 01, 2012 and December 31, 2012, stool samples of 330 adult outpatients admitted to gastroenterology department are investigated with an immunochromatographic test kit using monoclonal antibodies for detection of H. pylori antigen.Results: Among 330 patients' stool samples tested, 67 (20.3%) were positive. 18.6% of men and 22.2% of women were detected as positive. According to age groups, 17.1% patients were positive for 15-35 age groups, 27.1% patients were positive for 36-55 age groups and 18.2% patients were positive for above 56. Seasonal difference of H. pylori antigen positivity in stool samples was statistically significant (p=0.001). Highest positivity rate 29.7% was detected for winter months (December-January-February). According to logistic regression analysis, winter is found as a risk factor with statistically significant 2.295 times greater risk [p=0001, Exp (B) = 2.925, 95.0% C.I. for EXP (B) = 1.668-5.129]. Conclusion:H. pylori antigen positivity rate of our study is lower than other previously conducted studies in Turkey. But, positivity rates are higher among women compared to men, concordant with other studies. Even more, detection of high positivity rates in winter shows primary infection and/or relapse can be affected by seasonal changes. Bulgular:Test edilen toplam 330 dışkı örneğinden 67'si (%20,3) pozitif bulundu. Bu oran erkek hastalarda %18,6, kadın hastalarda ise %22,2 olarak tespit edildi. Yaş grubuna göre ise 15-35 yaş grubunda %17,1, 36-55 yaş grubunda %27,1, 56 yaş ve üzerindeki hastalarda ise %18,2 olarak saptandı. H. pylori antijen pozitifliğinin mevsimlere göre dağılımında istatistiksel olarak anlamlı bir farklılık tespit edildi (p=0,001). Buna göre en yüksek antijen pozitiflik oranı %29,7 ile kış mevsiminde (Aralık-Ocak-Şubat) bulundu. Yapılan lojistik regresyon analizinde kış ayları-nın H. pylori antijen pozitifliği yönünden 2,925 kat artırıcı bir risk faktörü olduğu tespit edildi (p=0,001).Sonuç: Çalışmamızda saptanan dışkı örneklerindeki H. pylori antijen pozitifliği, ülkemizde önceki yıllarda yapılmış çalışmalara göre daha düşük bulunmakla birlikte diğer çalışmalarla uyumlu olacak şekilde kadınlarda erkeklere göre daha yüksek düzeydedir. Ayrıca çalışmamızda kış aylarında diğer aylara göre daha yüksek pozitifliğin saptanması, primer enfeksiyon gelişimi, nüks veya bulaşın mevsimsel değişiklik gösterebileceğini ortaya koymaktadır. Anahtar kelimeler:Helicobacter pylori, gastroenteroloji, dışkı antijen testi

show abstract

Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: a Systematic Review

Cited by 183 publications

References 135 publications

An update of laboratory diagnosis of Helicobacter pylori in the Kingdom of Saudi Arabia

An update of laboratory diagnosis of Helicobacter pylori in the Kingdom of Saudi Arabia

Anemia and Helicobacter pylori Seroreactivity in a Rural Haitian Population

Evaluation of Helicobacter pylori antigen positivity in stool samples of patients with dyspeptic complaints in a tertiary care hospital

Contact Info

Product

Resources

About