Diagnosis of gastroesophageal reflux disease using a new questionnaire

Sugiyama, Yasuyuki; Kusano, Motoyasu; Sugimoto, Sayaka; Kawamura, Osamu; Maeda, Masaki; Minashi, Keiko; Kuribayashi, Shikou; Higuchi, Taiichi; Zai, Hiroaki; Ino, Kyoko; Horikoshi, Tsutomu; Moki, Fumitaka; Sugiyama, Tadashi; Toki, Munetoshi; Ohwada, Tsuneo; Mori, Masataka

doi:10.1111/j.1440-1746.2005.03776.x

Cited by 29 publications

(24 citation statements)

References 11 publications

(9 reference statements)

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“…Shimoyama et al reported less prevalence of pain in stomach at night in GERD group (grade M or worse) as one of differences between GERD group and non-GERD group (ulcer, gastritis etc.) [30]. As a result, when combining the results of these studies and the present study, acid reflux appears to be mild in grade N, and in terms of symptoms, grade N resembles EPS-type FD associated with ulcer symptoms (stomachache).…”

Section: Discussionsupporting

confidence: 46%

It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole—A Report from a Study with Japanese Patients

et al. 2008

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The hypothesis that non-erosive reflux disease (NERD) patients comprise various subgroups is gaining popularity. This study was conducted to investigate the possibility of categorizing NERD patients according to symptom types and response to acid-suppressive drug rabeprazole (RPZ) 10 mg/day. NERD patients were classified as grade N (endoscopically normal), M (minimal change), or erosive GERD, and answered a 51-item, yes-or-no questionnaire pre and post-treatment. Compared to erosive GERD, clear differences existed in pretreatment prevalence of symptoms and responsiveness to RPZ in grades N and M; the results suggested stomachaches (especially at night) were significant symptoms in grade N and dysmotility-like symptoms like bloated stomach were significant in grade M while gastroesophageal reflux symptoms were significant in erosive GERD. Clinical significance of classifying NERD was indicated from different symptoms and responsiveness to PPI.

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Section: Discussionsupporting

confidence: 46%

It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole—A Report from a Study with Japanese Patients

et al. 2008

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“…Over use of upper endoscopy contributes to higher health care costs without improving patient outcomes, so for identification of GERD symptoms in every day clinical practice, the questionnaire are developed and used as FSSG [12] . The questions related to 12 symptoms that the patients with GERD complain of most not only heart burn and acid taste but also dyspeptic symptoms such as heavy stomach and feeling full quickly [16] . In our study, there is significant frequency of heartburn, regurgitation and epigastric pain or discomfort in male than female and older age than younger age and this in agreement of the findings of El-Serag and Sonnenberg (1997) [17] .…”

Section: Resultsmentioning

confidence: 99%

Comparison of Endoscopic Findings With Gerd Symptoms Score in Zagazig University Hospitals, Egypt.

Ismail

Khalifa

2016

Zagazig University Medical Journal

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Background: Gastroesophageal reflux disease (GERD) may need repeated endoscopy for diagnosis and follow up, this may concern psychological and financial burden on patient. Aim of the work:The aim of our work was to evaluate the benefit of the FSSG as a useful and a practical tool for diagnosing of GERD patients compared to the endoscopic results. This was mainly to avoid repeated uses of endoscopy for diagnosis and may reduce the medical costs and save the patients time Patients & Methods: This study was carried out at Zagazig University, Faculty of Medicine, Internal Medicine Department, Gastroenterology and endoscopy unit during the period from June 2015 to December 2015.The subjects were 131 Egyptian patients aged ≥18 year (mean 46.3± 16.8 year; male/female ratio 1.8/1) who presented with symptoms of heartburn, regurgitation and epigastric pain or discomfort. They were scheduled for esophagogastroduodenoscopy. It was done after approval of Local Ethics Committee and patient's consent was obtained. Pre-endoscopy Procedure: Our study depends on a simplified questionnaire for evaluation of the symptoms of GERD called FSSG (Frequency Scale for Symptoms of GERD) which consists of 12 questions; all must be answered by all subjects Endoscopy Procedure: All subjects underwent esophagogastroduodenoscopy. The results of endoscopy were classified and graded according to Los Angeles classification into GERD A, B and C according to the severity of the endoscopic findings. After that the final endoscopic diagnosis was compared to the predicted diagnosis resulting from the Regression model and Equation. Results: Based on the endoscopic findings, the number of patients with GERD Los Angeles Class A, B and C was 18.3, 15.3 and 6.9 % respectively. Clinical obesity patients were 3 distributed as duodenal ulcer (DU) = 2 and GERD B = 1 patient. Overweight patients were 58 distributed as gastric ulcer (GU) = 13, DU = 7, functional dyspepsia (NUD) = 14, GERD A = 8, GERD B = 8 and GERD C = 8 patients. Normal weight patients were 63 distributed as GU = 14, DU = 11, NUD = 11, GERD A = 16, GERD B = 10 and GERD C = 1 patients. Underweight patients were 7 distributed as DU = 1, GU = 2, NUD = 3, GERD A = 0, GERD B = 1 and GERD C = 0 patients. Usage of the FSSG questionnaire with Regression Model help us to predict strongly GERD A by 95.8%, also GERD B by 95% and weakly predict DU by 81.8%, GERD C by 77.7%, GU by 60.7% and NUD by 50%.Conclusion: Noninvasive assessment tool FSSG questionnaire was useful for objective evaluation of symptoms in GERD patients and avoid repeated endoscopic examination which is undesirable in terms of medical costs and the burden on the patient and save our developing country efforts and resources.

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“…When the cutoff was set at 8 points, FSSG showed a sensitivity of 62% and a specificity of 59% [72,73]. Table 2 presents a summary of the prevalence of symptomatic GERD in Japan [30,43,45,[54][55][56][57][74][75][76][77][78][79][80][81].…”

Section: Prevalence and Clinical Characteristics Of Symptomatic Gerd mentioning

confidence: 99%

Epidemiology and clinical characteristics of GERD in the Japanese population

2009

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We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons for the increase in the prevalence of GERD may be due to increases in gastric acid secretion, a decrease in the Helicobacter pylori infection rate, more attention being paid to GERD, and advances in the concept of GERD. More than half of GERD patients had non-erosive reflux disease, and the majority (87%) of erosive esophagitis was mild type, such as Los Angeles classification grade A and grade B. There were several identified risk factors, such as older age, obesity, and hiatal hernia. In particular, mild gastric atrophy and absence of H. pylori infection influence the characteristics of GERD in the Japanese population. We also discuss GERD in the elderly; asymptomatic GERD; the natural history of GERD; and associations between GERD and peptic ulcer disease and H. pylori eradication. We examined the prevalence of GERD in patients with specific diseases, and found a higher prevalence of GERD, compared with that in the general population, in patients with diabetes mellitus, those with obstructive sleep apnea syndrome, and those with bronchial asthma. We provide a comprehensive review of GERD in the Japanese population and raise several clinical issues.

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Diagnosis of gastroesophageal reflux disease using a new questionnaire

Abstract: A novel questionnaire was developed. It was designed to detect the symptoms of GERD while simultaneously excluding non-GERD patients. This simplified nine-item simplified questionnaire had a sensitivity of 79.8%, a specificity of 53.6% and an accuracy of 63.4%.

Cited by 29 publications

References 11 publications

It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole—A Report from a Study with Japanese Patients

It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole—A Report from a Study with Japanese Patients

Comparison of Endoscopic Findings With Gerd Symptoms Score in Zagazig University Hospitals, Egypt.

Epidemiology and clinical characteristics of GERD in the Japanese population

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